Quantification of fat deposition in the testis and epididymis using mDIXON Quant sequence: correlation with age and ejaculation

Guo, Ruomi; Zhao, Ru-Zhen; Zhang, Jie; Yang, Fei; Wen, Huiquan; Zhang, Yong; Li, Qingling

doi:10.1007/s00261-018-1826-3

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…The modified Dixon fat quantification (mDixon-Quant) technique is a water-fat separation technology that enables semutaneous mapping of proton density fat fraction and transverse relaxation rate

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( 6 ), thus reflecting the fat contents and iron deposition in tissues. mDixon-Quant has been used to diagnose spinal lesions ( 7 ), detect liver lesions ( 8 , 9 ), measure testicular and epididymal fat content ( 10 ), and quantitatively analyze muscle fat content ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

APTw combined with mDixon−Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma

Meng

Song

et al. 2023

Front. Oncol.

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BackgroundTo investigate the value of amide proton transfer weighted (APTw) imaging combined with modified Dixon fat quantification (mDixon-Quant) imaging in determining the degree of differentiation of cervical squamous carcinoma (CSC) against histopathologic.MethodsMagnetic resonance imaging (MRI) data were collected from 52 CSC patients. According to histopathologic results, patients were divided into the poorly differentiated group (37 cases) and the well/moderately differentiated group (15 cases). The APTw value by APTw imaging and the fat fraction (FF) and transverse relaxation rate R2* values by mDixon-Quant were independently measured by two radiologists. Intra-class correlation coefficients (ICCs) were used to test the consistency of APTw, FF, and R2* values measured by the two observers. The Mann-Whitney U test was used to analyze the difference in each parameter between the two groups. Logistic regression analysis was used to assess the association between the degree of differentiation on histopathology and imaging parameters by APTw and mDixon Quant. The ROC curve was used to evaluate the diagnostic efficacy of various parameters and their combination in distinguishing the degree of CSC differentiation on histopathology. The DeLong test was used to access the differences among the area under the ROC curves (AUCs). The Pearson correlation coefficient was used to evaluate the correlation between APTw and mDixon-Quant imaging parameters.ResultsThe APTw means were 2.95 ± 0.78% and 2.05 (1.85, 2.65)% in the poorly and well/moderately differentiated groups, respectively. The R2* values were 26.62 (21.99, 33.31)/s and 22.93 ± 6.09/s in the poorly and well/moderately differentiated groups, respectively (P < 0.05). The AUCs of APTw, R2*, and their combination were 0.762, 0.686, and 0.843, respectively. The Delong test suggested statistical significance between R2* and the combination of APTw and R2*. R2* values showed a significant correlation with APTw values in the poorly differentiated group.ConclusionsAPTw combined with mDixon-Quant can be used to efficiently distinguish the differention degrees of CSC diagnosed on histopathology.

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Section: Introductionmentioning

confidence: 99%

APTw combined with mDixon−Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma

Meng

Song

et al. 2023

Front. Oncol.

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“…MMP9 is a member of the proteolytic enzyme family ( Fowlkes and Winkler, 2002 ), which is located on the sperm flagella membrane and involved in the regulation of spermatogenesis in epididymis, and considered a biomarker for semen quality ( Warinrak et al, 2015 ). A small amount of fat is deposited in the epididymis ( Guo et al, 2019 ). During sperm maturation in the epididymis, lipid contents in the sperm membrane change, which facilitates sperm motility ( Bjorkgren et al, 2015 ).…”

Section: Disscussionmentioning

confidence: 99%

Epididymal mRNA and miRNA transcriptome analyses reveal important genes and miRNAs related to sperm motility in roosters

et al. 2022

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Sperm motility is a crucial trait in chicken production, and the epididymis is an essential organ in the reproductive system. Currently, the molecular mechanisms underlying sperm motility in the epididymis are unclear. In this study, 8 cDNA libraries and eight miRNA libraries were constructed from roosters (4 chickens per group) with diverse sperm motility. After a comparative analysis of epididymal transcriptomes, we detected 84 differentially expressed genes ( DEG s) using the edgeR package. Integrated interpretation of DEGs indicated that MMP9, SLN, WT1, PLIN1 , and LRRIQ1 are the most promising candidate genes affecting sperm motility in the epididymis of roosters. MiR-146a, mir-135b, and mir-205 could play important regulatory roles in sperm maturation, capacitation, and motility. Additionally, a comprehensive analysis of the mRNA and miRNAs transcriptomes in silico identified a promising gene-miRNA pair miR-135b-HPS5, which may be a vital regulator of sperm motility in the epididymis. Our findings provide novel integrated information of miRNAs and genes that shed light on the regulatory mechanisms of fertility in roosters.

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Update on quantitative radiomics of pancreatic tumors

et al. 2021

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Radiomics is a newer approach for analyzing radiological images obtained from conventional imaging modalities such as computed tomography, magnetic resonance imaging, endoscopic ultrasonography, and positron emission tomography. Radiomics involves extracting quantitative data from the images and assessing them to identify diagnostic or prognostic features such as tumor grade, resectability, tumor response to neoadjuvant therapy, and survival. The purpose of this review is to discuss the basic principles of radiomics and provide an overview of the current clinical applications of radiomics in the field of pancreatic tumors.

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Quantification of fat deposition in the testis and epididymis using mDIXON Quant sequence: correlation with age and ejaculation

Cited by 8 publications

References 19 publications

APTw combined with mDixon−Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma

APTw combined with mDixon−Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma

Epididymal mRNA and miRNA transcriptome analyses reveal important genes and miRNAs related to sperm motility in roosters

Update on quantitative radiomics of pancreatic tumors

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