Quantification of mast cells in the uterine cervix of women infected with human immunodeficiency virus

Guimarães, Janaína Valadares; Costa, Fábio Luiz Paranhos; Andrade, Wanessa Machado; Vêncio, Eneida Franco; Salge, Ana Karina Marques; Siqueira, Karina Machado; Texeira, Vicente de Paula Antunes

doi:10.1016/j.anndiagpath.2011.02.009

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…The genital mucosae of HIV-infected women showed increased mast cell density, and increased numbers of mucosal mast cells were noted in men with AIDS-associated diarrhea (25,26), suggesting a potential role for mast cells in HIV-1 infection. We hence investigated the potential contribution of mucosal mast cells to HIV-1 infection and found that mast cells isolated from gut mucosal tissues express a variety of HIV-1 attachment factors (HAFs) and mediate capture of HIV-1 and the subsequent viral trans-infection of CD4 ϩ T cells.…”

mentioning

confidence: 98%

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells

Jiang

Wei

et al. 2016

J Virol

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Despite great advances in antiretroviral therapies, human immunodeficiency virus type 1 (HIV-1) infection still remains a major global epidemic. Sexual transmission is the principal route of HIV-1 acquisition, making the genital and rectal mucosae the major sites of viral transmission. The intestinal mucosa is also the primary site where HIV-1 amplifies to disseminate virus throughout the host and is critical in the early events in the establishment of infection and evasion of immune defenses. However, the mechanisms contributing to the establishment of HIV-1 primary infection remain largely unexplored. Cell-associated viral dissemination has been proposed to play pivotal roles in HIV-1 primary infection, and multiple cell types, such as dendritic cells (DCs) and macrophages, have been reported to be hijacked by HIV-1 for local and systemic viral spread (1-4). DCs provide one of the best-described cell models for understanding cell-mediated HIV-1 capture and dissemination (1,(5)(6)(7)(8).Mast cells are derived from hematopoietic progenitor cells and undergo final maturation in vascularized tissues. Mast cells are strategically in close contact with the host-environment interface, such as the skin, airway, gastrointestinal tract, and urinary tract. They express numerous pathogen-associated molecular patterns and play an important role in the early immunosurveillance for many pathogens (9, 10). Mast cells can interact with various immune cells in complex ways, including release of soluble factors and direct contact (11), and are important immune effector and modulatory cells that help to link innate and adaptive immunity in the fight against pathogens (9,(12)(13)(14). They have been shown to be important for host defense against various viruses, such as vesicular stomatitis virus, Sendai virus, hantavirus, reovirus, dengue virus, influenza virus, herpes simplex virus, and murine cytomegalovirus (15-23). Additionally, mast cells can serve as antigenpresenting cells and participate in traditional immunologic synapse formation with T cells to mediate antigen-specific T cell activation (24).

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confidence: 98%

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells

Jiang

Wei

et al. 2016

J Virol

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“…In the present study, although individuals with HIV have higher densities of c‐kit or tryptase mast cells in CG or CP than do individuals without HIV, no statistically significant differences can be observed. Women with HIV have been shown to have significantly higher mast cell counts in the uterine cervix than women without HIV, suggesting that HIV infection may increase or be associated with an augmented mast cell count 35 …”

Section: Discussionmentioning

confidence: 99%

“…Women with HIV have been shown to have significantly higher mast cell counts in the uterine cervix than women without HIV, suggesting that HIV infection may increase or be associated with an augmented mast cell count. 35 Macrophages and memory T-cells are commonly considered the most significant stable reservoirs for persistent HIV infection. However, there is mounting evidence that other viral reservoirs exist.…”

Section: Discussionmentioning

confidence: 99%

Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy

Segundo

Souto

Costa

et al. 2013

Journal of Periodontology

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“…Recent studies, however, have increasingly indicated that mast cell number can vary during HIV-1 infection. The increase in the number of mast cells in cervical DOI: 10.5114/ceji.2012.32729 lymph nodes of HIV-positive men, as compared with healthy subjects, were observed [11], and a significantly higher mast cell count were found in the chorionic epithelium of the uterine cervix of HIV-infected women than of non-HIV-infected [12]. Also, the gingival tissue of HIV-1-positive patients with chronic marginal periodontitis as well as healthy gingiva displayed higher mast cell density in comparison with non-infected counterparts [13,14].…”

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confidence: 87%

Are mast cells the Trojan horse in HIV-1 infection?

Witczak¹,

Brzezińska‐Błaszczyk²

2012

cejoi

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Quantification of mast cells in the uterine cervix of women infected with human immunodeficiency virus

Cited by 5 publications

References 17 publications

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells

Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy

Are mast cells the Trojan horse in HIV-1 infection?

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Quantification of mast cells in the uterine cervix of women infected with human immunodeficiency virus

Cited by 5 publications

References 17 publications

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 + T Cells

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 + T Cells

Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy

Are mast cells the Trojan horse in HIV-1 infection?

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Product

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Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells

Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans -Infection of CD4 ⁺ T Cells