Quantification of monohydroxylated polycyclic aromatic hydrocarbons in human urine samples using solid-phase microextraction coupled with glass-capillary nanoelectrospray ionization mass spectrometry

Yang, Bicheng; Fang, Shufen; Wan, Xin; Luo, Yong; Zhou, Jiangyan; Li, You; Li, Yunjun; Wang, Feng; Huang, Ouping

doi:10.1016/j.aca.2017.04.009

Cited by 51 publications

(33 citation statements)

References 69 publications

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“…The intra‐ and inter‐day precisions (RSD) ranged from 2.4 to 8.7% and 2.9 to 9.9%, respectively. As overviewed in Table , LODs (0.02–0.1 ng/mL) and recoveries (77.5–97.1%) for the target compounds are comparable with the other reported results obtained by LC‐MS/MS for the similar multi‐analyte determination of OH‐PAHs in urine samples .…”

Section: Resultssupporting

confidence: 88%

“…Thus, efficient sample pretreatment is a required step as enabling enrichment of target analytes and removal of other nontarget compounds. Numerous pretreatment methodologies, such as liquid‐liquid extraction (LLE) , SPE , magnetic SPE , dispersive liquid‐liquid microextraction , and solid‐phase microextraction (SPME) have been proposed to improve the sensitivity, specificity, and cost of the method. Among these methods, SPE is an interesting technique due to the versatility of sorbent materials, consumption of less solvent, and the compatibility with separation instruments.…”

Section: Introductionmentioning

confidence: 99%

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Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solid‐phase extraction coupled with LC‐MS/MS

et al. 2019

J of Separation Science

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The biomonitoring of hydroxy polycyclic aromatic hydrocarbons in urine, as a direct way to access multiple exposures to polycyclic aromatic hydrocarbons, has raised great concerns due to their increasing hazardous health effects on humans. Solidphase extraction is an effective and useful technique to preconcentrate trace analytes from biological samples. Here, we report a novel solid-phase extraction method using a graphene oxide incorporated monolithic syringe for the determination of six hydroxy polycyclic aromatic hydrocarbons in urine coupled with liquid chromatographytandem mass spectrometry. The effect of graphene oxide amount, washing solvent, eluting solvent, and its volume on the extraction performance were investigated. The fabricated monoliths gave higher adsorption efficiency and capacity than the neat polymer monolith and commercial C 18 sorbent. Under the optimum conditions, the developed method provided the detection limits (S/N = 3) of 0.02-0.1 ng/mL and the linear ranges of 0.1-1500 ng/mL for six analytes in urine sample. The recoveries at three spiked levels ranged from 77.5 to 97.1%. Besides, the intra column-to-column (n = 3) and inter batch-to-batch (n = 3) precisions were ≤ 9.8%. The developed method was successfully applied for the determination of hydroxy polycyclic aromatic hydrocarbons in urine samples of coke oven workers.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solid‐phase extraction coupled with LC‐MS/MS

et al. 2019

J of Separation Science

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“…In another study by Naccarato et al, the Generally speaking, urine is undoubtedly the preferred matrix among the analyzed biological fluids because of its greater biological half-life and its less invasive sampling. This trend is confirmed in the last lustrum since most of the published works on this topic have been directed, as well as to the assay of markers of several pathological conditions [210][211][212], toward the determination of several contaminants in urine samples [14,74,83,[213][214][215][216][217][218][219]. Few studies focused on hair [220][221][222], three papers were published about analysis in blood/serum [29,223,224], and one regarding meconium [225].…”

Section: The Final Endpoint: Bio-clinical Matricesmentioning

confidence: 95%

“…The satisfactory results achieved in terms of the lifetime of coatings and validation parameters created not only new alternatives for polycyclic aromatic hydrocarbon exposure assessment but also opened new perspectives for the application of direct immersion solid-phase microextraction to the analysis of bio-clinical matrices. As for food analysis, various coatings were proposed for the analysis of urine, such as C 18 /PAN [213], layered double hydroxide/graphene (LDH-G) [218], inorganic-organic hybrid nanocomposite [219], and cross-linked PIL [83] for the determination of hydroxylated PAHs as metabolites of PAHs [213,219], organochlorine pesticides [218], and endocrine-disrupting chemicals [83]. In the study proposed by Yang et al [213], an improved low-cost direct SPME-MS technique with glass capillary was further developed for the determination of five typical OH-PAHs in urine samples using a C18-SPME fiber, which then was inserted into a prefilled glass-capillary with spray solvent to generate ions for MS analysis.…”

Section: The Final Endpoint: Bio-clinical Matricesmentioning

confidence: 99%

Recent Applications and Newly Developed Strategies of Solid-Phase Microextraction in Contaminant Analysis: Through the Environment to Humans

Naccarato

Tagarelli

2019

Separations

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The present review aims to describe the recent and most impactful applications in pollutant analysis using solid-phase microextraction (SPME) technology in environmental, food, and bio-clinical analysis. The covered papers were published in the last 5 years (2014–2019) thus providing the reader with information about the current state-of-the-art and the future potential directions of the research in pollutant monitoring using SPME. To this end, we revised the studies focused on the investigation of persistent organic pollutants (POPs), pesticides, and emerging pollutants (EPs) including personal care products (PPCPs), in different environmental, food, and bio-clinical matrices. We especially emphasized the role that SPME is having in contaminant surveys following the path that goes from the environment to humans passing through the food web. Besides, this review covers the last technological developments encompassing the use of novel extraction coatings (e.g., metal-organic frameworks, covalent organic frameworks, PDMS-overcoated fiber), geometries (e.g., Arrow-SPME, multiple monolithic fiber-SPME), approaches (e.g., vacuum and cold fiber SPME), and on-site devices. The applications of SPME hyphenated with ambient mass spectrometry have also been described.

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“…Considering the matrix effect of complex sample in direct ionization process, the minor sample pre‐treatment such as extraction and separation processes has been increasingly attracted to improve the ionization efficiency of analytes. For example, solid‐phase micro‐extraction fibre, thin‐layer chromatography plate, micro‐SPE tip, and other functional materials were considered as ESI emitters for enhanced detection of analytes in complex samples at molecular level, which showed the high efficience of removing impurities and concentrating analytes prior to ionization. In addition, QuEChERS extraction procedure (a standard sample treatment protocol) were usually used for sample pre‐treatment prior to MS analysis.…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of carbendazim in complex matrices by electrospray ionization mass spectrometry with syringe filter needle

et al. 2018

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The determination of pesticide residues is an indispensable task in controlling food safety and environment protection. Carbendazim is one of the extensive uses of pesticides in the agricultural industry. In this study, a simple method utilizing syringe filter has been applied as electrospray ionization emitter for mass spectrometric identification and quantification of carbendazim in complex matrices including soil, natural water, and fruit juice samples, which contain many insoluble materials. With online syringe filter of the complex samples, most of insoluble materials such as soil were excluded in spray ionization process due to the filter effect, and analytes were subsequently sprayed out from syringe needle for mass spectrometric detection. The pore sizes of filters and diameters of syringe needles also were investigated. The analytical performances, including the linear range (1-200 ng·mL ), limit of detection (0.2-0.6 ng·mL , S/N > 3), limit of quantitation (3.5-8.6 ng·mL , S/N > 10), reproducibility (6.4%-12.5%, n = 6), and recoveries (72.1%-91.0%, n = 6) were well acceptable for direct analysis of raw samples. Matrix effect for detection of carbendazim in soil samples also was experimentally investigated. This study demonstrated that syringe filter needle coupled with electrospray ionization mass spectrometry is a simple, efficient, and sensitive method for detection of pesticide residues in water, soil, and fruit juice for risk assessment.

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Quantification of monohydroxylated polycyclic aromatic hydrocarbons in human urine samples using solid-phase microextraction coupled with glass-capillary nanoelectrospray ionization mass spectrometry

Cited by 51 publications

References 69 publications

Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solid‐phase extraction coupled with LC‐MS/MS

Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solid‐phase extraction coupled with LC‐MS/MS

Recent Applications and Newly Developed Strategies of Solid-Phase Microextraction in Contaminant Analysis: Through the Environment to Humans

Rapid determination of carbendazim in complex matrices by electrospray ionization mass spectrometry with syringe filter needle

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