Quantification of myocardium at risk in myocardial perfusion SPECT by co‐registration and fusion with delayed contrast‐enhanced magnetic resonance imaging – an experimental <i>ex vivo</i> study

Soneson, Helen; Engblom, Henrik; Pals, Jesper van der; Erlinge, David; Heiberg, Einar; Arheden, Håkan

doi:10.1111/j.1475-097x.2011.01051.x

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Evaluation of MPS images was performed by using anatomical information from the high resolution T1-weighted ex-vivo images and perfusion information from MPS according to a previously described method [ 17 ]. In short, both T1-weighted and MPS images were re-sampled to similar resolutions and were spatially matched using purpose-designed software.…”

Section: Methodsmentioning

confidence: 99%

Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction

Nordlund

Kanski

Jablonowski

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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BackgroundAccurate assessment of myocardium at risk (MaR) after acute myocardial infarction (AMI) is necessary when assessing myocardial salvage. Contrast-enhanced steady-state free precession (CE-SSFP) is a recently developed cardiovascular magnetic resonance (CMR) method for assessment of MaR up to 1 week after AMI. Our aim was to validate CE-SSFP for determination of MaR in an experimental porcine model using myocardial perfusion single-photon emission computed tomography (MPS) as a reference standard and to test the stability of MaR-quantification over time after injecting gadolinium-based contrast.MethodsEleven pigs were subjected to either 35 or 40 min occlusion of the left anterior descending artery followed by six hours of reperfusion. A technetium-based perfusion tracer was administered intravenously ten minutes before reperfusion. In-vivo and ex-vivo CE-SSFP CMR was performed followed by ex-vivo MPS imaging. MaR was expressed as % of left ventricular mass (LVM).ResultsThere was good agreement between MaR by ex-vivo CMR and MaR by MPS (bias: 1 ± 3% LVM, r 2 = 0.92, p < 0.001), between ex-vivo and in-vivo CMR (bias 0 ± 2% LVM, r 2 = 0.94, p < 0.001) and between in-vivo CMR and MPS (bias -2 ± 3% LVM, r 2 = 0.87, p < 0.001. No change in MaR was seen over the first 30 min after contrast injection (p = 0.95).ConclusionsContrast-enhanced SSFP cine CMR can be used to measure MaR, both in vivo and ex vivo, in a porcine model with good accuracy and precision over the first 30 min after contrast injection. This offers the option to use the less complex ex-vivo imaging when determining myocardial salvage in experimental studies.

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Section: Methodsmentioning

confidence: 99%

Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction

Nordlund

Kanski

Jablonowski

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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“…In short, the automatic segmentation finds the centerline through the LV wall and identifies the endocardium and epicardium based on an individually estimated wall thickness and signal intensity values within the image. Following delineation, the ischemic area was assessed in contiguous short-axis slices from base to apex using a method for semi-automatic quantification [23]. All myocardium below a threshold of 50 percent of the maximum counts was considered ischemic and expressed as a percentage of the LV volume.…”

Section: Methodsmentioning

confidence: 99%

Regional wall function before and after acute myocardial infarction; an experimental study in pigs

Pahlm

Ubachs

Heiberg

et al. 2014

BMC Cardiovasc Disord

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BackgroundLeft ventricular function is altered during and after AMI. Regional function can be determined by cardiac magnetic resonance (CMR) wall thickening, and velocity encoded (VE) strain analysis. The aims of this study were to investigate how regional myocardial wall function, assessed by CMR VE-strain and regional wall thickening, changes after acute myocardial infarction, and to determine if we could differentiate between ischemic, adjacent and remote segments of the left ventricle.MethodsTen pigs underwent baseline CMR study for assessment of wall thickening and VE-strain. Ischemia was then induced for 40-minutes by intracoronary balloon inflation in the left anterior descending coronary artery. During occlusion, 99mTc tetrofosmin was administered intravenously and myocardial perfusion SPECT (MPS) was performed for determination of the ischemic area, followed by a second CMR study. Based on ischemia seen on MPS, the 17 AHA segments of the left ventricle was divided into 3 different categories (ischemic, adjacent and remote). Regional wall function measured by wall thickening and VE-strain analysis was determined before and after ischemia.ResultsMean wall thickening decreased significantly in the ischemic (from 2.7 mm to 0.65 mm, p < 0.001) and adjacent segments (from 2.4 to 1.5 mm p < 0.001). In remote segments, wall thickening increased significantly (from 2.4 mm to 2.8 mm, p < 0.01). In ischemic and adjacent segments, both radial and longitudinal strain was significantly decreased after ischemia (p < 0.001). In remote segments there was a significant increase in radial strain (p = 0.002) while there was no difference in longitudinal strain (p = 0.69). ROC analysis was performed to determine thresholds distinguishing between the different regions. Sensitivity for determining ischemic segments ranged from 70-80%, and specificity from 72%-77%. There was a 9% increase in left ventricular mass after ischemia.ConclusionDifferentiation thresholds for wall thickening and VE-strain could be established to distinguish between ischemic, adjacent and remote segments but will, have limited applicability due to low sensitivity and specificity. There is a slight increase in radial strain in remote segments after ischemia. Edema was present mainly in the ischemic region but also in the combined adjacent and remote segments.

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“…All of these threshold values were derived from phantom studies. In this study the threshold value was taken from an animal study based on ex-vivo MR images and ex-vivo MPS images 21 .…”

Section: Discussionmentioning

confidence: 99%

An automatic method for quantification of myocardium at risk from myocardial perfusion SPECT in patients with acute coronary occlusion

Soneson

Engblom

Hedström

et al. 2010

Journal of Nuclear Cardiology

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Quantification of myocardium at risk in myocardial perfusion SPECT by co‐registration and fusion with delayed contrast‐enhanced magnetic resonance imaging – an experimental ex vivo study

Cited by 9 publications

References 18 publications

Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction

Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction

Regional wall function before and after acute myocardial infarction; an experimental study in pigs

An automatic method for quantification of myocardium at risk from myocardial perfusion SPECT in patients with acute coronary occlusion

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