Quantification of oxygen metabolic rates in Human brain with dynamic ¹⁷O MRI: Profile likelihood analysis

Abstract

1,2yPurpose: Parameter identifiability and confidence intervals were determined using a profile likelihood (PL) analysis method in a quantification model of the cerebral metabolic rate of oxygen consumption (CMRO 2

Reproducibility of CMRO2 determination using dynamic 17O MRI

“…Obtained CMRO 2 values of GM and WM yielded consistent results and showed good reproducibility. Results for WM were in good agreement with previous studies (16)(17)(18)(19), whereas GM values were estimated higher. The confirmation of the reproducibility of direct dynamic 17…”

“…vivo study for nominal spatial resolutions of (7.5-10 mm) 3 (16)(17)(18). A major difference compared to previous work can be found in the absolute estimates for the K L and K G parameters, which were reported by only one group so far (16).…”

“…The principle of determining functional dynamics is based on the production of H 17 2 O and its quantification in combination with a metabolic model (three-phase model) (16) that connects the dynamic information with the metabolic process. So far, this direct CMRO 2 assessment has been sparingly used in human studies at various magnetic field strengths (16)(17)(18)(19). The approach itself has not yet been investigated under the aspect of inter-and intrasubject reproducibility and stability.…”

“…Signal evolution of external reference vials during an inhalation experiment. Images were reconstructed with a temporal resolution of Dt ¼ 1:00 min (SNR ¼[16][17][18][19][20][21]. The signal variation is smaller than 63%.…”

High‐resolution dynamic oxygen‐17 MR imaging of mouse brain with golden‐ratio–based radial sampling and k‐space–weighted image reconstruction

“…Quantification of the cerebral metabolic rate of oxygen consumption (CMRO 2 (8,10,11). Most of these studies used spectroscopic imaging methods with Cartesian encoding (10), but alternative 17 O-MRI methods have used ultrashort echo time sequences with non-Cartesian encoding (12)(13)(14), including the density-adapted three-dimensional (3D) radial pulse sequence (12,13) and the flexible twisted projection imaging acquisition (14). These methods have achieved a spatial resolution of 8 to 8.5 mm and a temporal resolution of 40 to 50 s in humans at high field.…”