Quantification of Parotid Gland Uptake of Pertechnetate Using a Gamma Scintillation Camera and a "Region-of-Interest" System

Schall, Gerald L.; Larson, Steven M.; Anderson, Linda; Griffith, James M.

doi:10.2214/ajr.115.4.689

Cited by 28 publications

(11 citation statements)

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“…In the present study, we did not use the conventional SGS approach that has been performed as either multiple planar imaging [10][11][12] or dynamic acquisition with TAC analysis [13][14][15][16][17]. Instead, quantitative SPECT/CT was applied to the functional evaluation of salivary gland disease.…”

Section: Discussionmentioning

confidence: 99%

“…The SGS has been performed in a 2-dimensional planar mode using Tc-99m pertechnetate in patients with xerostomia since the early 1970s [9]. Using multiple static images [10][11][12] or dynamic time-activity curves (TACs) [13][14][15][16][17], the degree of uptake/excretion of Tc-99m pertechnetate has been employed for functional evaluation of the salivary glands. However, the wide variability and poor reliability of all 2-dimensional approaches did not meet the standards required for clinical trial application or disease classification.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients

Kim

Lee

et al. 2018

Nucl Med Mol Imaging

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Purpose The purpose of the study was to investigate the usefulness of quantitative salivary single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate in Sjögren's syndrome (SS). Methods We retrospectively reviewed quantitative salivary SPECT/CT data from 95 xerostomic patients who were classified as either SS (n = 47, male:female = 0:47, age = 54.60 ± 13.16 y [mean ± SD]) or non-SS (n = 48, male:female = 5:43, age = 54.94 ± 14.04 y) by combination of anti-SSA/Ro antibody, labial salivary gland biopsy, unstimulated whole saliva flow rate, and Schirmer's test. Thyroid cancer patients (n = 43, male:female = 19:24, age = 46.37 ± 12.13 y) before radioactive iodine therapy served as negative controls. Quantitative SPECT/CT was performed pre-stimulatory 20 min and post-stimulatory 40 min after injection of Tc-99m pertechnetate (15 mCi). The %injected dose at 20 min and the %excretion between 20 and 40 min were calculated for parotid and submandibular glands, generating four quantitative parameters: %parotid uptake (%PU), %submandibular uptake (%SU), %parotid excretion (%PE), and %submandibular excretion (%SE). The most useful parameter for SS diagnosis was investigated. Results The uptake parameters (%PU and %SU) were significantly different among the SS, non-SS, and negative controls (p = 0.005 for %PU and p < 0.001 for %SU, respectively), but the excretion parameters (%PE and %SE) were not (p > 0.05 for both). The %PU and %SU were significantly lower in SS than in the negative controls and non-SS (p < 0.05 for all pair-wise comparisons). Additionally, the %SU was significantly lower in non-SS than in the negative controls (p < 0.05). Receiver-operating characteristic analysis revealed that the %SU had the greatest area-under-the curve of 0.720 (95% confidence interval = 0.618-0.807). Using the optimal cutoff value of %SU ≤ 0.07%, SS was identified with a sensitivity of 70.21% and a specificity of 70.83%. Conclusion Reduced submandibular uptake of Tc-99m pertechnetate at 20 min (%SU) was proved useful for the diagnosis of SS. Quantitative salivary gland SPECT/CT holds promise as an objective imaging modality for assessment of salivary dysfunction and may facilitate accurate classification of SS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients

Kim

Lee

et al. 2018

Nucl Med Mol Imaging

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“…Xerostomia (i.e., dry mouth) is caused by decreased salivary secretion resulting from various systemic diseases and drug side effects (Bahn and Conn, 1972; Schall et al , 1972; Ettinger, 1981; Spielman et al , 1981; Navazesh and Ship, 1983). Systemic conditions associated with reduced salivary flow rates include Sjögren’s syndrome (SS) (Tatal et al , 1978), neuropsychiatric disorders (Astor et al , 1999), diabetes mellitus (Sreebny, 1990; Astor et al , 1999), dehydration (Astor et al , 1999), thyroid dysfunction (Tatal et al , 1978), hepatitis C (Dickson, 1997), and cancer therapies (Lockhart and Clark, 1990; Epstein and Chow, 1999; Silverman, 1999).…”

Section: Introductionmentioning

confidence: 99%

Close association between oral Candida species and oral mucosal disorders in patients with xerostomia

et al. 2012

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Oral Diseases (2012) 18, 667–672 Objective: Heightened interest in oral health has lead to an increase in patients complaining of xerostomia, which is associated with various oral mucosal disorders. In this study, we investigated the relationship between Candida species and oral mucosal disorders in patients with xerostomia. Subjects and Methods: We evaluated whole salivary flow rate and presence of oral mucosal disorders in 48 patients with xerostomia and 15 healthy controls. The number of Candida species was measured as colony‐forming units after propagation on selective medium. Identification of Candida at the species level was carried out by polymerase chain reaction and restriction fragment length polymorphism analysis. We then examined the relationship between Candida species and oral mucosal symptoms. Results: Compared with controls, patients with xerostomia exhibited significantly decreased whole salivary flow rate, increased rate of oral mucosal symptoms, and higher numbers of Candida. Salivary flow rate negatively correlated with the number Candida. Among patients with oral candidiasis, Candida albicanswas isolated from the tongue mucosa and Candida glabratawas isolated from the angle of the mouth. Conclusion: These results suggest that particular Candida species are involved in the pathogenesis of oral mucosal disorders in patients with xerostomia.

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“…SchilddrUse [37,43] wurde von rinigen Autoren vorgeschlagen, den 99''Tc-Pertechnetatuptake in den Speicheldrüsen als MaB für deren Parenchymfunktion zu berechnen [32,33,35,39,54,56,60,[62][63][64][65]73]. Von diesen Autoren werden auch 20* [56] 9 0,75±0,45* k.A. [60] 45 0,56±0,29 [62] 44 0,40±0,15* [64] 25 0,31 ±0,02…”

Section: Analog Zur Quantitizierung Der Parenchymfunktion Derunclassified

Durchführung und Indikationen der quantitativen Sialoszintigraphie

Brenner²,

Klutmann³

et al. 1997

Laryngo-Rhino-Otol

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Quantification of Parotid Gland Uptake of Pertechnetate Using a Gamma Scintillation Camera and a "Region-of-Interest" System

Cited by 28 publications

References 0 publications

Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients

Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients

Close association between oral Candida species and oral mucosal disorders in patients with xerostomia

Durchführung und Indikationen der quantitativen Sialoszintigraphie

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