Quantification of perfusion and metabolism in an autism mouse model assessed by diffuse correlation spectroscopy and<scp>near‐infrared</scp>spectroscopy

Rinehart, Benjamin; Poon, Chien-Sing; Sunar, Ulaş

doi:10.1002/jbio.202000454

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Further, relative differences in tissue dynamics between a normal brain and stroke‐affected regions were observed [18]. Another approach is the combination of NIRS with DCS adopted in this study, as a noninvasive technology for monitoring cerebral blood flow without any contrast enhancer [32, 34]. This method has already been validated for measuring hemodynamic parameters through previously reported experiments [19, 21].…”

Section: Discussionmentioning

confidence: 99%

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Wang

et al. 2022

Journal of Biophotonics

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Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low‐cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation (n = 5) or air emboli (n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Wang

et al. 2022

Journal of Biophotonics

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“…The acquired frames were corrected against the average intensity of 500 background images, where the intensity of the mean of dark background images was subtracted from the signal as dark noise correction before commencing data collection for the experiment, and an area of 200 × 200 pixels of the corrected speckle pattern was used for 1/K 2 s calculation. In our initial experiment, we compared the SCOS results with a lab-standard diffuse correlation spectroscopy system, which was detailed in our previous publication [32]. Briefly, the DCS system consists of a long-coherence (~10 m) laser source (785 nm Crysta-Laser Inc., Reno, NV, USA), eight NIR-optimized single-photon counting modules (SPCM-NIR, Excelitas, Vaudreuil-Dorion, QC, Canada), and an 8-channel auto-correlator board (Correlator.com), of which one channel was used.…”

Section: Resultsmentioning

confidence: 99%

Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy

Langri,

Sunar

2023

Brain Sciences

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Neurocritical care focuses on monitoring cerebral blood flow (CBF) to prevent secondary brain injuries before damage becomes irreversible. Thus, there is a critical unmet need for continuous neuromonitoring methods to quantify CBF within the vulnerable cortex continuously and non-invasively. Animal models and imaging biomarkers can provide valuable insights into the mechanisms and kinetics of head injury, as well as insights for potential treatment strategies. For this purpose, we implemented an optical technique for continuous monitoring of blood flow changes after a closed head injury in a mouse model, which is based on laser speckle contrast imaging and a fiber camera-based approach. Our results indicate a significant decrease (~10%, p-value < 0.05) in blood flow within 30 min of a closed head injury. Furthermore, the low-frequency oscillation analysis also indicated much lower power in the trauma group compared to the control group. Overall, blood flow has the potential to be a biomarker for head injuries in the early phase of a trauma, and the system is useful for continuous monitoring with the potential for clinical translation.

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“…DCS has been shown to be a reliable method to obtain CBF contrasts in animals and humans. Rinehart et al found that mice in the autism group had significantly lower CBF compared to control group by using DCS [28]. However, to our best knowledge, DCS…”

Section: Introductionmentioning

confidence: 93%

Cerebral blood flow measured by diffuse correlation spectroscopy in children with autism spectrum disorder

Fang

Wen

et al. 2023

Journal of Biophotonics

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Diffuse correlation spectroscopy (DCS) was used to measure resting‐state cerebral blood flow (CBF) in temporal lobes of children with autism spectrum disorder (ASD) and typically developing (TD) children. 22 children with ASD and 34 age‐matched TD children were recruited to participate in the experiment. DCS signals were recorded with 3 long source‐detector (SD) channels (SD distance = 22.0 mm) and 1 short SD channel (SD distance = 10.5 mm) from each side of the temporal lobe. Significant difference in CBF between left and right hemispheres was observed in ASD group, but not in TD group. With the degree of CBF lateralization as a discrimination feature, a leave‐one‐out ROC curve was plotted with the area‐under‐curve (AUC) value of 0.731 ± 0.010, indicating children with ASD could be discriminated from TD children. This suggested CBF lateralization in temporal lobes measured with DCS might serve as a discriminative feature for ASD.This article is protected by copyright. All rights reserved.

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Quantification of perfusion and metabolism in an autism mouse model assessed by diffuse correlation spectroscopy andnear‐infraredspectroscopy

Abstract: There is a need for quantitative biomarkers for early diagnosis of autism.Cerebral blood flow and oxidative metabolism parameters may show superior

Cited by 7 publications

References 44 publications

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy

Cerebral blood flow measured by diffuse correlation spectroscopy in children with autism spectrum disorder

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