Quantification of potentially toxic elements in food material by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) via pressed pellets

Papaslioti, Evgenia-Maria; Parviainen, Annika; Alpiste, M.J. Román; Marchesi, Claudio; Garrido, Carlos J.

doi:10.1016/j.foodchem.2018.08.118

Cited by 33 publications

(19 citation statements)

References 17 publications

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“…However, it can be assumed that their importance will increase in the coming years. Laser systems working with different wavelengths can be used to ablate large biomolecules, such as DNA or proteins, as well as smaller metabolites and elements [32,33]. Some analytical platforms also enable the direct nontargeted measurement of food samples without any extraction, for example by means of infrared (IR) spectroscopy [34] (near IR [NIR] [35], mid IR [36]), Raman spectroscopy [37]) as well as different ionization sources for MS: direct analysis in real time (DART) [38], desorption electrospray ionization (DESI), rapid evaporative ionization mass spectrometry (REIMS) [39], liquid extraction surface analysis (LESA) [40], or laser ablation electrospray ionization (LAESI).…”

Section: Sample Extractionmentioning

confidence: 99%

Food authentication in real life: How to link nontargeted approaches with routine analytics?

Creydt¹,

Fischer²

2020

Electrophoresis

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In times of increasing globalization and the resulting complexity of trade flows, securing food quality is an increasing challenge. The development of analytical methods for checking the integrity and, thus, the safety of food is one of the central questions for actors from science, politics, and industry. Targeted methods, for the detection of a few selected analytes, still play the most important role in routine analysis. In the past 5 years, nontargeted methods that do not aim at individual analytes but on analyte profiles that are as comprehensive as possible have increasingly come into focus. Instead of investigating individual chemical structures, data patterns are collected, evaluated and, depending on the problem, fed into databases that can be used for further nontargeted approaches. Alternatively, individual markers can be extracted and transferred to targeted methods. Such an approach requires (i) the availability of authentic reference material, (ii) the corresponding highresolution laboratory infrastructure, and (iii) extensive expertise in processing and storing very large amounts of data. Probably due to the requirements mentioned above, only a few methods have really established themselves in routine analysis. This review article focuses on the establishment of nontargeted methods in routine laboratories. Challenges are summarized and possible solutions are presented.

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Section: Sample Extractionmentioning

confidence: 99%

Food authentication in real life: How to link nontargeted approaches with routine analytics?

Creydt¹,

Fischer²

2020

Electrophoresis

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“…Compared to the analysis of soft animal tissues, the sample preparation of plants is more tedious, often requiring embedding and sectioning, matrix matching, and dry samples, if no cryogenic cell is employed. Nevertheless, the development of new sample preparation methods with novel dehydration and embedding procedures prior to sectioning 216,224,225 as well as novel approaches for quantification 226 have opened new perspectives and possibilities for LA-ICP-MS. Narewski et al 227 were the first to apply LA-ICP-MS to the determination of major, minor, and trace elements in bark samples of Scots pine (Pinus sylvestris L.) to evaluate the anthropogenic pollution burden in the environment. They presented an innovative approach for matrix-matched standardization and calibration by pressing different bark layers containing varying elemental concentrations into pellets.…”

Section: Plant Bioimagingmentioning

confidence: 99%

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

et al. 2021

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Elemental imaging gives insight into the fundamental chemical makeup of living organisms. Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements that define structure and function. Many disease states feature a disturbance in elemental homeostasis, and understanding how, and most importantly where, has driven the development of laser ablation−inductively coupled plasma−mass spectrometry (LA-ICP-MS) as the principal elemental imaging technique for biologists. This review provides an outline of ICP-MS technology, laser ablation cell designs, imaging workflows, and methods of quantification. Detailed examples of imaging applications including analyses of cancers, elemental uptake and accumulation, plant bioimaging, nanomaterials in the environment, and exposure science and neuroscience are presented and discussed. Recent incorporation of immunohistochemical workflows for imaging biomolecules, complementary and multimodal imaging techniques, and image processing methods is also reviewed.CONTENTS

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“…Sample sizes for (i.e., number of points in) these calibration curves depended on the number of calibration CRMs for which an analyte concentration was available, one to three (Table II); since three replicates were run on each calibration CRM, three to nine data points were used per calibration curve. 23 Na, 24 Mg, 27 Al, 31 P, 39 K, 44 Ca, 49 Ti, 51 V, 52 Cr, 55 Mn, 57 Fe, 59 Co, 60 Calibration curves were obtained using linear models, forced through the origin, and fitted separately for each analyte (a) in each sample set (s). Specifically, median signal intensity (I a,s ; counts per second) was used as the dependent variable and the corresponding theoretical concentrations (mg/g), C a,s , was set as the independent variable; i.e., I a,s ¼ b a,s C a,s , where b a,s is the calibration curve slope for analyte a in sample set s. Concentrations (mg/g dry weight) of analyte a for test samples in set s were determined (C 0 a,s ) from intensity values as C 0 ,s ¼ I ,s ,s .…”

Section: Concentration Quantificationmentioning

confidence: 99%

“…Laser ablation offers several advantages in analytical chemistry, 21 many of which align with green chemistry principles. 22,23 Specifically, laser ablation facilitates low limits of detection; concentration determinations spanning many orders of magnitude; twodimensional mapping; nondestructive analysis; analysis of dry samples, prepared without the use of hazardous reagents; and concurrent determination of a wide range of elements. Consequently, LA-ICP-MS has been used in a wide range of applications in life sciences and environmental chemistry to analyze samples ranging from plant and animal materials, to sediments, dust, and ash.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, LA-ICP-MS has been used in a wide range of applications in life sciences and environmental chemistry to analyze samples ranging from plant and animal materials, to sediments, dust, and ash. 19,20,23,24 While the use of LA-ICP-MS to analyze biological tissues has grown in the last decade, 24 its ability to provide fully quantitative analysis is complicated by methodological limitations, 24 Most notably, several analysis steps are dependent on the sample matrix. In particular, the rate of ablation depends on the physical properties of the sample and the interaction between the laser beam with the surface being ablated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Elemental Composition in Soft Biological Tissue Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry: Method Validation

2021

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Determination of elemental concentrations in biological tissue is fundamental to many environmental studies. Analytical methods typically used to quantify concentrations in such studies have minimum sample volumes that necessitate lethal or impactful collection of tissues. Laser-ablation inductively coupled mass spectrometry (LA-ICP-MS) has small sample-volume requirements and offers environmental practitioners an opportunity to employ low-impact sample-collection methods. Environmental applications of LA-ICP-MS are limited by the lack of validated methods, partly due to the need for dry samples and scarcity of matrix-matched certified reference materials (CRMs). This study validates an LA-ICP-MS method to determine concentrations of 30 elements in soft biological tissue (fish ovary and muscle). Small tissue samples (median: 0.48 grams (g); inter-quartile range: 0.30 g to 0.56 g wet weight) were dehydrated, powdered, compressed into pellets (weighing approximately 0.03 mg) and analysed using LA-ICP-MS alongside three matrix-matched CRMs. The method yielded concentration determinations for CRM elements that were typically accurate to within 30% of theoretical concentrations, and precise (relative standard deviation [RSD] <20%). These results were repeatable: accuracy rarely deviated from theoretical values by more than 20%, and precision rarely exceeded 33%. Determinations for biological samples were replicable irrespective of tissue (ovary or muscle). There was good linearity between analyte signal strength and theoretical concentration (median R2 â¥ 0.981 for all elements) across ranges typically encountered in environmental studies. Concentrations could not be consistently obtained (i.e., determined concentrations were typically below detection limits) for boron, vanadium, molybdenum, and cadmium in muscles, and arsenic in both ovaries and muscles; however, detection limits were sufficiently low for most environmental contexts. Further methodological refinement could include the incorporation of spiked standards to extend linear ranges, and fine-tuning instrument parameters to obtain smoother signal intensities for rare elements. The method presented promotes the use low-impact sample-collection methods while enabling high-quality determinations of elemental concentrations in biological tissues.

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Quantification of potentially toxic elements in food material by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) via pressed pellets

Cited by 33 publications

References 17 publications

Food authentication in real life: How to link nontargeted approaches with routine analytics?

Food authentication in real life: How to link nontargeted approaches with routine analytics?

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

Determination of Elemental Composition in Soft Biological Tissue Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry: Method Validation

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