Quantification of Quetiapine in Human Plasma by LC–MS–MS

Kundlik, Mohan L.; Kambli, Sandeep; Shah, Viral N.; Patel, Yashwant D.; Gupta, Santosh K.; Sharma, Ram Jee; Zaware, Bhaskar H.; Kuchekar, Shashikant R.

doi:10.1365/s10337-009-1353-z

Cited by 12 publications

(7 citation statements)

References 11 publications

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“…Many quantitative methods have been developed for the determination of GLM in biological fluids, such as high-performance liquid chromatography with ultraviolet detection (HPLC-UV) which showed, relatively, very high quantitative limits, that are far from the actual amount of non-metabolized GLM [6][7][8][9]. Also, liquid chromatography-tandem mass spectrometry (LC-MS) has been developed for its determination [10][11][12][13]. Generally, two extraction procedures were used for the recovery of GLM from plasma, including liquid-liquid extraction (LLE) [9] and solid-phase extraction (SPE) [8,10].…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale: Pharmacokinetic study after oral administration

Kammoun

Awan

Elawady

et al. 2021

AChrom

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Although glimepiride (GLM) is the first-line treatment of Type II diabetes, low extraction recovery is still a significant limitation in previous plasma analysis methods. An optimized solid-phase extraction method of GLM in human plasma with excellent extraction recovery, 100 ± 0.06%, was achieved using liquid chromatography-electrospray ionization tandem mass spectrometry and Gliclazide (GLZ) as an internal standard. GLM was extracted from 100 µL plasma sample using Sep-Pak® vac 1cc (100 mg) C18 column and methylene chloride: methanol (2: 1, v/v) as eluant. Both GLM and GLZ were monitored by a triple quad mass spectrometer applying positive multiple reaction monitoring mode (+MRM). The protonated precursor ions and product ions of GLM and GLZ were m/z 491(352), and m/z 324 (127), respectively. The detection and measurement of low levels of GLM in human plasma reached to picogram range (limit of detection (LOD) = 60 pg/mL, limit of quantification (LOQ) = 200 pg/mL). The method was validated in terms of selectivity, linearity, recovery, accuracy, and precision. The method was successfully applied to the pharmacokinetic study of GLM following oral administration of 1 mg GLM tablets to 12 healthy volunteers.

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Section: Introductionmentioning

confidence: 99%

LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale: Pharmacokinetic study after oral administration

Kammoun

Awan

Elawady

et al. 2021

AChrom

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“…Many analytical methods are reported by different workers for the determination of QTF in pure form, formulations and in biological materials. High-performance liquid chromatography (HPLC) [4][5][6][7][8][9][10][11][12], ultra-performance liquid chromatographic with tandem mass spectrometry (UPLC-MS) [13,14], HPLC with different detection systems such as chemiluminescence [15], electrospray ionization mass spectrometry (ESI-MS) [16][17][18][19] and tandem mass spectrometry [20][21][22][23][24], and gas chromatography [25,26] techniques have been used for the assay of QTF in body fluids. However, QTF has been determined in pharmaceuticals by titrimetric [27,28], potentiometric [29], polarographic [30], differential pulse and square wave voltammetric [31], capillary zone electrophoretic [32,33], high performance thin layer chromatographic (HPTLC) [34][35][36], HPLC [12,[37][38][39][40][41], UPLC [42] and spectrophotometric [28,32,[43...…”

Section: Introductionmentioning

confidence: 99%

Selective Potentiometric Sensors for the Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Rajendraprasad¹,

Basavaiah²

2020

Braz. J. Anal. Chem.

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Quetiapine fumarate (QTF), chemically known as 1-[2-(2-hydroxyethoxy)-ethyl]-4-(dibenzo[b,f][1,4] thiazepin-11-yl)-piperazinium hemifumarate, is one of the derivatives of dibenzothiazepine. It is used as an atypical antipsychotic drug and is prescribed for the treatment of schizophrenia and bipolar disorders. Fabrication and the application of two selective potentiometric sensors for determination of QTF in pharmaceuticals and spiked human urine are presented. The membrane sensors are fabricated by preparing ion pair complexes of QTF with sodium tetraphenyl boron (NaTPB) and phosphotungstic acid (PTA). Using the ion-associates of QTF-NaTPB and QTF-PTA, Sensor I and Sensor II, respectively, were designed in polyvinyl chloride matrix using dibutyl phthalate as a plasticizer in THF. The fabricated Sensor I and II are applicable for the quantification QTF over the concentration range from 6.25 × 10-5 to 3.5 × 10-3 M QTF. The operative pH ranges for the determination of QTF were found to be in the range from 1.5 to 2.20 and from 1.00 to 1.6, for Sensor I and II with the Nernstian slopes of 58.34±1.04 and 57.23±0.78 mV/decade, respectively. The regression coefficient values of 0.9992 and 0.9982 show good correlation between the measured potentials and concentrations using Sensor I and II, respectively. The limit of detection (LOD) values for the fabricated sensor are calculated and reported. The experimental conditions have been optimized to reach the effective performance characteristics of the sensors. Standard-addition procedure is followed to study the effect of additives in tablets and foreign species in spiked human urine. The results revealed no such variations due to presence of additives or foreign species or endogenous species. The fabricated sensors are subjected to validation to check accuracy, precision, robustness and ruggedness. The mean accuracy for the determination of QTF is very close to 100%. The developed and validated sensors have yielded excellent results.

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“…Several analytical methods have been reported for the determination of QTF in biological fluids and pharmaceuticals. QTF was determined in biological materials by HPLC with UV [1][2][3][4][5][6][7][8], chemiluminescence [9], electrospray ionization MS [10][11][12][13], tandem MS / MS detection [14][15][16][17], UPLC with tandem MS detection [18,19], GC [20,21] and voltammetry [22]. Different techniques such as polarography [23], potentiometry [24], capillary zone electrophoresis [25,26], HPTLC [27][28][29], HPLC [30][31][32][33] and spectrophotometry [25,[34][35][36] have earlier been used for the determination of QTF in pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

A Novel Validated Rp-HPLC Method for the Determination of Quetiapine Fumarate in Bulk and Pharmaceutical Tablet Dosage Forms: Application to Dissolution Study

Macharla¹,

Karthikeyan²,

Babu³

2013

Int. Res. J. Pharm.

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A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Quetiapine Fumarate in pharmaceutical tablet dosage forms. RP-HPLC method was developed by using Welchrom C18Column (4.6 X 250 mm, 5 µm), Shimadzu LC-20AT Prominence Liquid Chromatograph. The mobile phase composed of 10 mM Phosphate buffer (pH-3.0, adjusted with triethylamine): acetonitrile (50:50 v/v). The flow rate was set to 1.0 mL.min-1 with the responses measured at 230 nm using Shimadzu SPD-20A Prominence UV-Vis detector. The retention time of Quetiapine Fumarate was found to be 3.260 minutes. Linearity was established for Quetiapine Fumarate in the range of 2-10 µg.mL-1 with correlation coefficient 0.9999. The validation of the developed method was carried out for specificity, linearity, precision, accuracy, robustness, limit of detection, limit of quantitation. The developed method can be used for routine quality control analysis of Quetiapine Fumarate in pharmaceutical tablet dosage form

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Quantification of Quetiapine in Human Plasma by LC–MS–MS

Cited by 12 publications

References 11 publications

LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale: Pharmacokinetic study after oral administration

LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale: Pharmacokinetic study after oral administration

Selective Potentiometric Sensors for the Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

A Novel Validated Rp-HPLC Method for the Determination of Quetiapine Fumarate in Bulk and Pharmaceutical Tablet Dosage Forms: Application to Dissolution Study

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