Quantification of <scp>l</scp>‐carvone in toothpastes available on the <scp>S</scp>wedish market

Kroona, Liv; Warfvinge, Gunnar; Isaksson, Marléne; Ahlgren, Camilla; Dahlin, Jakob; Sörensen, Östen; Bruze, Magnus

doi:10.1111/cod.12803

Cited by 25 publications

(43 citation statements)

References 51 publications

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“…Sensitization to other flavours found in oral healthcare products, such as peppermint, cinnamal, cinnamyl alcohol and limonene, were not common in the investigated group, but a considerable number of patients had reactions to fragrance mix I and balsam of Peru, which contain flavour substances such as cinnamal and cinnamyl alcohol. Spearmint oil also contains 10-15% limonene (d-limonene) (1), a common fragrant constituent in cosmetic products (21) and also present in toothpastes (4). During a large part of the investigated time period the test preparation of limonene was not intentionally oxidized and it is essentially the oxidation products in limonene that are sensitizers, e.g.…”

Section: Discussionmentioning

confidence: 99%

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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Kroona¹,

Isaksson²,

Ahlgren³

et al. 2018

Acta Derm Venerol

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Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.

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Section: Discussionmentioning

confidence: 99%

“…Oral healthcare products are a major source of exposure, and carvone is a constituent of most toothpastes (4,5). Carvone is considered a weak sensitizer (6) and the prevalence of contact allergy in patch-tested cohorts has been estimated to be 1.6-2.8% (7,8).…”

mentioning

confidence: 99%

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Kroona¹,

Isaksson²,

Ahlgren³

et al. 2018

Acta Derm Venerol

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“…The results showed that L-carvone was found in 64 of 66 toothpastes with the concentration of 0.00005-0.35%. In ten toothpastes on which limonene was labelled, the concentration of L-carvone was higher than 0.1% [89]. One control study investigated whether contact allergies due to potential allergens were causing oral lichen lesions in patients exposed to a variety of dental material.…”

Section: Carvonementioning

confidence: 99%

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

2018

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Essential oils are widely incorporated in cosmetic products, perfumes and related household products due to the variety of their properties but mainly due to their pleasant odour. The composition of these volatile natural complex mixtures may vary depending on the quality of plant material from which they were obtained and the extraction method by which they were derived. These factors are also important in ensuring the safe use of essential oils in personal care products. As they contain compounds with varied chemical structure and effects, skin sensitivity and irritations as well as other symptoms may arise after their application. Although essential oils are considered as safe and nontoxic when used at low concentrations, available scientific literature indicates that essential oils and their compounds may possess a strong allergy potential. This review focuses on side effects and allergy contact dermatitis caused by selected essential oils and their single compounds in cosmetic products, summarizing data from the most recent scientific literature.

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“…If a weak (fragrance) contact allergen is found in many products, the patient may need to sort out many of his cosmetic products, as illustrated by a 60-year-old Spanish patient, who suffered from periorbital eczema due to sensitisation to benzyl salicylate, and identified 5 of her own products needing to be discarded [ 75 ]. L -Carvone is a known contact allergen and has been found (as constituent of mint flavour) in 64 of 66 Swedish brand toothpastes examined; in 10 of these the concentration exceeded 0.1% [ 76 ]. In case of contact allergy to such a widely used agent, formulation of a toothpaste by a pharmacy may be considered [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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Quantification of l‐carvone in toothpastes available on the Swedish market

Cited by 25 publications

References 51 publications

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Contact Allergy: A Review of Current Problems from a Clinical Perspective

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