Quantification of selected antidepressants and antipsychotics in clinical samples using chromatographic methods combined with mass spectrometry: A review (2006-2015)

Sistik, P.; Turjap, Miroslav; Iordache, Mihaela; Saldanha, Helena M E B; Lemr, Karel; Bednář, Petr

doi:10.5507/bp.2015.065

Cited by 20 publications

(14 citation statements)

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“…These three SGAPs are among the most efficacious ones and their TDMs are among the better studied. In a recent review, Sistik et al () reported that many analytical techniques have been used for SGAP TDM, but more recently LC‐MS/MS has emerged as the technique of choice. On the other hand, they emphasized that sample preparation is not a completely resolved issue.…”

Section: Resultsmentioning

confidence: 67%

“…These three SGAPs are among the most efficacious ones and their TDMs are among the better studied. In a recent review, Sistik et al (2016) reported that many analytical techniques have been used for SGAP (Mandrioli et al, 2011;Saracino et al, 2010) and three to measure olanzapine (Gopinath et al, 2012;Proença et al, 2013;Sivsivadze et al, 2017), we found no article using SPE for an analytic system measuring more than one of these antipsychotics. Moreover, by using a better sample preparation with two methods of causing protein precipitation at the time of sample preparation (Section 2.3) and during the online SPE (Section 2.4),…”

Section: Contribution To the Literaturementioning

confidence: 74%

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Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography–tandem mass spectrometry coupled with on‐line solid‐phase extraction

Ruan

Guo

Zhou

et al. 2018

Biomedical Chromatography

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A recent guideline recommends therapeutic drug monitoring for risperidone, paliperidone and olanzapine, which are frequently used second-generation antipsychotics. We developed a simple high-performance liquid chromatography-tandem mass spectrometry coupled with an online solid-phase extraction method that can be used to measure risperidone, paliperidone and olanzapine using small (40 μL) samples. The analytes were extracted from serum samples automatically pre-concentrated and purified by C (5 μm, 2.1 × 30 mm) solid-phase extraction cartridges, then chromatographed on an Xbidge™ C column (3.5 μm, 100 × 2.1 mm) thermostatted at 30°C with a mobile phase consisting of 70% acetonitrile and 30% ammonium hydroxide 1% solution at an isocratic flow rate of 0.3 mL/min, and detected with tandem mass spectrometry. The assay was validated in the concentration range from 2.5 to 160 ng/mL. Intra- and inter-day precision for all analytes was between 1.1 and 8.2%; method accuracy was between 6.6 and 7.6%. The risperidone and paliperidone assay was compared with a high-performance liquid chromatography-ultraviolet assay currently used in our hospital for risperidone and paliperidone therapeutic drug monitoring, and the results of weighted Deming regression analysis showed good agreement. For the olanzapine assay, we compared 20 samples in separate re-assays on different days; all the relative errors were within the 20% recommended limit.

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Section: Resultsmentioning

confidence: 67%

Section: Contribution To the Literaturementioning

confidence: 74%

Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography–tandem mass spectrometry coupled with on‐line solid‐phase extraction

Ruan

Guo

Zhou

et al. 2018

Biomedical Chromatography

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“…Mental health issues, including depression and mood disorders, have become far more frequent in recent decades than in the past. 15 The rapid development of new antidepressants with minimal side effects is a desirable effort. In fact, new generations of antidepressants with improved side effect profiles, such as ARP, are becoming increasingly available for the treatment of emotional disorders.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, new generations of antidepressants with improved side effect profiles, such as ARP, are becoming increasingly available for the treatment of emotional disorders. 4 , 15 …”

Section: Discussionmentioning

confidence: 99%

Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure

et al. 2018

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Aripiprazole (ARP), a quinolinone derivative, is an atypical antipsychotic drug that is used in the treatment of schizophrenia. ARP has an extensive distribution and more than 99% of the ARP and dehydro-ARP, the main active metabolite, is bound to plasma proteins. However, information regarding the protein binding of ARP is limited. In this study, we report on a systematic study of the protein binding of ARP. The interaction of ARP and structurally related compounds with human serum albumin (HSA) was examined using equilibrium dialysis, circular dichroism (CD) spectroscopy, fluorescent probe displacement, and an X-ray crystallographic analysis. The binding affinities (nK) for ARP and its main metabolite, dehydro-ARP with HSA were found to be significantly higher than other structurally related compounds. The results of equilibrium dialysis experiments and CD spectral data indicated that the chloro-group linked to the phenylpiperazine ring in the ARP molecule plays a major role in the binding of these ligands to HSA. Furthermore, fluorescent probe displacement results indicated that ARP appears to bind at the site II pocket in subdomain III. A detailed CD spectral analysis suggests that the chloro-group linked to the phenylpiperazine ring may control the geometry of the ARP molecule when binding in the site II binding pocket. X-ray crystallographic analysis of the ARP–HSA complex revealed that the distance between the chlorine atom at the 3-positon of dichlorophenyl-piperazine on ARP and the sulfur atom of Cys392 in HSA was 3.4–3.6 Å. A similar halogen bond interaction has also been observed in the HSA structure complexed with diazepam, which also contains a chloro-group. Thus, the mechanism responsible for the binding of ARP to a protein elucidated here should be relevant for assessing the pharmacokinetics and pharmacodynamics of ARP in various clinical situations and for designing new drugs.

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“…Although majority of these methodologies are sufficiently accurate and precise, the intricate pretreatment processes (e.g. extraction and evaporation) and long chromatographic separation times make them less favorable for routine TDM application (Sistik et al, ). For improvements, recently, ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) has attracted attention (Patteet et al, ).…”

Section: Introductionmentioning

confidence: 99%

Development of a UPLC‐MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients

Wang

2017

Biomedical Chromatography

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A highly feasible and reliable ultra-high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti-schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone and ziprasidone) simultaneously. To meet the requirements of practical clinical usage (easy handling, high throughput and cost effectiveness), the pretreatment process was simplified (only including protein precipitation and mobile phase dilution steps) and the UPLC separation cycle was set within 6 min. The whole methodology was carefully validated according to the latest international guidelines showing the excellent selectivity, accuracy, precision, applicability and stability. After a 10 month clinical application, a retrospective analysis of 253 positive samples was carried out to investigate conformance with the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie therapeutic reference range for Chinese patients. The results suggested good consistency for olanzapine, aripiprazole, paliperidone and ziprasidone, while for amisulpride, the plasma concentration level (445.2 ± 231.5 ng/mL) was relatively higher than the recommended range (100-320 ng/mL). We supposed that such phenomenon indicated the necessity of reconstructing a Chinese-specific therapeutic reference range for amisulpride treatment, which would be helpful to improve medication efficiency and safety for Chinese patients.

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Quantification of selected antidepressants and antipsychotics in clinical samples using chromatographic methods combined with mass spectrometry: A review (2006-2015)

Cited by 20 publications

References 100 publications

Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography–tandem mass spectrometry coupled with on‐line solid‐phase extraction

Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography–tandem mass spectrometry coupled with on‐line solid‐phase extraction

Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure

Development of a UPLC‐MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients

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