Quantification of slow-wave EEG induced by atropine: Effects of physostigmine, amphetamine and haloperidol

Santucci, Vincent; Glatt, A.; Demieville, Henri; Olpe, Hans‐Rudolf

doi:10.1016/0014-2999(81)90082-0

Cited by 16 publications

(2 citation statements)

References 16 publications

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“…The anticholinergic drug (1 -100 mg / kg) did in fact produce synchronization in the neocortical EEG pattern characterized by slow-wave, high-voltage activity (36,37).…”

Section: Discussionmentioning

confidence: 96%

Diazepam Protects Against the Enhanced Toxicity of Cocaine Adulterated With Atropine

et al. 2008

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Abstract. We examined the toxicity of cocatropine (cocaine / atropine mixture) and the therapeutic potential of diazepam on some behavioral and physiological parameters in rats. Atropine (20 and 60 mg / kg) or cocaine (40 mg / kg) alone did not induce any seizure or death, but the combination significantly increased both, after both acute and binge treatment. There was a significant increase of EEG mean total spectral power in cocatropine-in comparison with cocaine-treated animals. Hyperlocomotion was observed in non-seizuring rats treated with cocaine or cocatropine. Cocaine, atropine 60, and cocatropine (40 + 20 and 40 + 60) all induced hyperthermic effects in non-seizuring rats, while cocatropine (40 + 60)-seizuring animals had hypothermia. An initial hypertensive and tachycardiac effect within 15 min was followed by a secondary fall in the cocatropine (40 + 60) group. Cocatropine toxicity was partially or fully reversed by diazepam (5 mg / kg), given intraperitoneally after the first seizure. The present findings provide, for the first time, details of a synergistic toxic effect of the cocaine / atropine mixture and of the potential of diazepam for treating cocatropine-related hospital emergencies.

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“…The anticholinergic drug (1 -100 mg / kg) did in fact produce synchronization in the neocortical EEG pattern characterized by slow-wave, high-voltage activity (36,37).…”

Section: Discussionmentioning

confidence: 96%

Diazepam Protects Against the Enhanced Toxicity of Cocaine Adulterated With Atropine

et al. 2008

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“…Diffuse axonal injury, resulting in cortical deafferentation, has been the suggested mechanism of delta waves in humans following concussion (Huang et al., 2014 ). Delta waves have also been induced in adult animal studies by injection of atropine (Castro‐Zaballa et al., 2019 ; Santucci et al., 1981 ; Schaul et al., 1978 ). Atropine causes deafferentation by blocking, or limiting, acetylcholine within the cholinergic pathway.…”

Section: Discussionmentioning

confidence: 99%

MEG measured delta waves increase in adolescents after concussion

et al. 2022

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Introduction:The purpose of this study is to determine if delta waves, measured by magnetoencephalography (MEG), increase in adolescents due to a sports concussion.Methods: Twenty-four adolescents (age 14-17) completed pre-and postseason MRI and MEG scanning. MEG whole-brain delta power was calculated for each subject and normalized by the subject's total power. In eight high school football players diagnosed with a concussion during the season (mean age = 15.8), preseason delta power was subtracted from their postseason scan. In eight high school football players without a concussion (mean age = 15.7), preseason delta power was subtracted from postseason delta power and in eight age-matched noncontact controls (mean age = 15.9), baseline delta power was subtracted from a 4-month follow-up scan.ANOVA was used to compare the mean differences between preseason and postseason scans for the three groups of players, with pairwise comparisons based on Student's t-test method.Results: Players with concussions had significantly increased delta wave power at their postseason scans than nonconcussed players (p = .018) and controls (p = .027). Conclusion:We demonstrate that a single concussion during the season in adolescent subjects can increase MEG measured delta frequency power at their postseason scan.

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Relationship between cortical electrical and cardiac autonomic activities in the awake lizard,Gallotia galloti

2000

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ECG and EEG signals were simultaneously recorded in lizards, Gallotia galloti, both in control conditions and under autonomic nervous system (ANS) blockade, in order to evaluate possible relationships between the ANS control of heart rate and the integrated central nervous system activity in reptiles. The ANS blockers used were prazosin, propranolol, and atropine. Time-domain summary statistics were derived from the series of consecutive R-R intervals (RRI) of the ECG to measure beat-to-beat heart rate variability (HRV), and spectral analysis techniques were applied to the EEG activity to assess its frequency content. Both prazosin and atropine did not alter the power spectral density (PSD) of the EEG low frequency (LF: 0.5-7.5 Hz) and high frequency (HF: 7.6-30 Hz) bands, whereas propranolol decreased the PSD in these bands. These findings suggest that central β-adrenergic receptor mechanisms could mediate the reptilian waking EEG activity without taking part any α 1 -adrenergic and/or cholinergic receptor systems. In 55% of the lizards in control conditions, and in ~43% of the lizards under prazosin and atropine, a negative correlation between the coefficient of variation of the series of RRI value (CV RRI ) and the mean power frequency (MPF) of the EEG spectra was found, but not under propranolol. Consequently, the lizards' HRV-EEG-activity relationship appears to be independent of α 1 -adrenergic and cholinergic receptor systems and mediated by β-adrenergic receptor mechanisms.

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Quantification of slow-wave EEG induced by atropine: Effects of physostigmine, amphetamine and haloperidol

Cited by 16 publications

References 16 publications

Diazepam Protects Against the Enhanced Toxicity of Cocaine Adulterated With Atropine

Diazepam Protects Against the Enhanced Toxicity of Cocaine Adulterated With Atropine

MEG measured delta waves increase in adolescents after concussion

Relationship between cortical electrical and cardiac autonomic activities in the awake lizard,Gallotia galloti

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