Quantifying dynamic contrast‐enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters

Workie, D; Dardzinski, Bernard J.

doi:10.1002/mrm.20597

Cited by 35 publications

(30 citation statements)

References 21 publications

(32 reference statements)

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“…Workie et al (42,43) validated the linear relationship for 3D-GRE images under condition of low Gd-DTPA concentrations (11). Our fitted transfer constant is also equal to apparent K trans as defined in their work.…”

Section: Discussionsupporting

confidence: 70%

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Baek

Chen

et al. 2008

Magnetic Resonance Imaging

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Proton MR spectroscopy ( 1 H MRS) and dynamic contrast-enhanced (DCE) MR imaging provide functional information, including vascular volume, vascular permeability, and choline (Cho) metabolism. In this study, we applied these two imaging modalities to quantitatively characterize 36 malignant breast lesions in 32 patients and analyzed the correlation between them. The Cho concentration was quantified by single-voxel 1 H MRS using water as an internal reference. The measured Cho levels ranged from 0.32 to 10.47 mmol/kg, consistent with previously reported values. In 25 mass type lesions, the Cho concentration was significantly correlated with tumor size (r = 0.69, p < 0.0002). In addition, the Cho level was found to be significantly higher in lesions presenting as mass type lesions compared to non-mass type diffuse enhancements (p = 0.035). The enhancement kinetics from tissues covered within each MRS voxel were measured and analyzed with a 2-compartmental model to obtain pharmacokinetic parameters K trans and k ep . A significant correlation was found between the Cho level and pharmacokinetic parameter k ep (r = 0.62, p < 0.0001), indicating that tissues with a high Cho level have higher wash-out rates in DCE MR imaging. The results suggest a correlation between choline metabolism and angiogenesis activity, which might be explained by the association of Cho with cell replication and angiogenesis required to support tumor growth.

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Section: Discussionsupporting

confidence: 70%

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Baek

Chen

et al. 2008

Magnetic Resonance Imaging

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“…The accuracy and precision of parameterizations gained from compartmental modeling (9 -11) and in particular the errors introduced in the definition of the arterial input function (AIF) has attracted considerable research interest (12)(13)(14)(15). In theory, the use of an individually measured AIF will increase the accuracy with which parameterizations may be obtained relative to the use of an assumed AIF (16,17).…”

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confidence: 99%

Comparison of errors associated with single‐ and multi‐bolus injection protocols in low‐temporal‐resolution dynamic contrast‐enhanced tracer kinetic analysis

Roberts

Buckley

Parker

2006

Magnetic Resonance in Med

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Accurate sampling of the arterial input function (AIF) in lowtemporal-resolution quantitative dynamic contrast-enhanced MRI (DCE-MRI) studies is crucial for accurate and reproducible parameter estimation. However, when conventional AIFs are sampled at low temporal resolution, they introduce an unpredictable degree of error. An alternative double contrast agent (CA) bolus injection protocol designed to compensate for temporal mis-sampling of the AIF and tissue uptake curve was simulated in addition to a commonly used single CA bolus injection protocol. A range of tissue uptake curves for each AIF form were generated using a distributed parameter model, and Monte Carlo simulation studies were performed over a range of offset times (to mimic temporal mis-sampling), temporal resolutions and SNR in order to compare the performance of both AIF forms in compartmental modeling. Insufficient data sampling of the single bolus AIF at temporal resolutions in excess of 9 s leads to large errors, which can be reduced by employing an additional, appropriately administered, second CA bolus injection. Magn Reson Med 56:611-619, 2006.

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“…Therefore, the T 2 *-neglecting method fails with concentration underestimation ranging up to 14%, while our first order approximation yields accurate concentration values when compared with the numerical conversion method. Incorrect determination of the AIF, and in particular of the peak concentration, has been acknowledged as an important error source affecting the accuracy of the kinetic parameters (17,(20)(21)(22). Cheng et al found that the relative error in the transendothelial transfer constant K trans is roughly inversely proportional to the relative error in the AIF amplitude (22).…”

Section: Discussionmentioning

confidence: 99%

First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

Naeyer

Debergh

Deene

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate the accuracy of a method neglecting T 2 *-relaxation, for the conversion of spoiled gradient echo pulse sequence signal intensity to contrast agent (CA) concentration, in dynamic contrast enhanced MRI studies. In addition a new closed form conversion expression is proposed that accounts for a first order approximation of T 2 *-relaxation. Materials and Methods:The accuracy of both conversion methods is compared theoretically by means of simulations for four pulse sequences from literature. Both methods are tested in vivo against the numerical conversion method for measuring the arterial input function in mice.Results: Simulations show that the T 2 *-neglecting method underestimates typical tissue CA concentrations (0 mM to 2 mM) up to 6%, while the errors for arterial concentrations (0 mM to 10 mM) range up to 43%. The results from our first order method are numerically indistinguishable from the simulation input values in tumor tissue, while for arterial concentrations the error is reduced up to a factor 10. In vivo, peak Gd-DOTA concentration is underestimated up to 14% with the T 2 *-neglecting method and up to 0.9% with our first order method. Conclusion:Our conversion method reduces the underestimation of CA concentration severely in a broad physiological concentration range and is easy to perform in any clinical setting.

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Quantifying dynamic contrast‐enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters

Abstract: Quantification of dynamic contrast-enhanced (DCE) MRI based on pharmacokinetic modeling requires specification of the arterial input function (AIF).

Cited by 35 publications

References 21 publications

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Comparison of errors associated with single‐ and multi‐bolus injection protocols in low‐temporal‐resolution dynamic contrast‐enhanced tracer kinetic analysis

First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

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Quantifying dynamic contrast‐enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters

Abstract: Quantification of dynamic contrast-enhanced (DCE) MRI based on pharmacokinetic modeling requires specification of the arterial input function (AIF).

Cited by 35 publications

References 21 publications

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer

Comparison of errors associated with single‐ and multi‐bolus injection protocols in low‐temporal‐resolution dynamic contrast‐enhanced tracer kinetic analysis

First order correction for T2*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

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First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity