Quantifying Oral Analgesic Consumption Using a Novel Method and Comparison with Patient-Controlled Intravenous Analgesic Consumption

Striebel, H. W.; Scheitza, W.; Philippi, W.; Behrens, U.; Toussaint, Susanne

doi:10.1213/00000539-199805000-00027

Cited by 19 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, our patients could independently titrate the administration of nalbuphine to control their pain via the patient-controlled analgesia device. This patient-controlled analgesia implies on-demand, intermittent, and self-controlled administration of analgesic agents, providing individual opioid titration with excellent results [18][19][20]. Since this study demonstrated lower total opioid consumption in the low-dosage group and a comparable satisfaction score among the three-dosages groups after two hours post-operation, we infer that low-dosage nalbuphine could potentially be efficient for post-operative pain management in minimally invasive surgery.…”

Section: Discussionmentioning

confidence: 66%

“…According to Zhao et al's reports, once the morphine equivalent dose reaches a threshold, approximately every 4 mg increase in the morphine-equivalent dose is related to increasing the meaningful adverse effects of opioid usage [26]. By using a patient-controlled analgesia device, our study could reach the optimized opioid usage for patients with excellent results [18][19][20]. Moreover, opioid consumption did not reveal an obvious gap of a 4 mg morphine-equivalent dose among dosages, irrespective of the analysis of the accumulated doses or their time intervals (Table 2).…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

Chen,

Kuo,

Chuang

et al. 2024

Medicina

View full text Add to dashboard Cite

Background and Objectives: Optimal opioid analgesia is an excellent analgesia that does not present unexpected adverse effects. Nalbuphine, acting on the opioid receptor as a partial mu antagonist and kappa agonist, is considered a suitable option for patients undergoing laparoscopic surgery. Therefore, we aim to investigate the appropriate dosage of nalbuphine for post-operative pain management in patients with laparoscopic cholecystectomy. Materials and Methods: Patients were randomly categorized into low, medium, and high nalbuphine groups. In each group, a patient control device for post-operative pain control was programed with a low (0.05 mg/kg), medium (0.10 mg/kg), or high (0.20 mg/kg) nalbuphine dose as a loading dose and each bolus dose with a lockout interval of 7 min and without background infusion. Primary and secondary outcomes included the post-operative pain scale and nalbuphine consumption, and episodes of post-operative opioid-related adverse events and satisfactory scores. Results: The low-dosage group presented a higher initial self-reported pain score in comparison to the other two groups for the two hours post-op (p = 0.039) but presented lower nalbuphine consumption than the other two groups for four hours post-op (p = 0.047). There was no significant difference in the analysis of the satisfactory score and adverse events. Conclusions: An appropriate administration of nalbuphine could be 0.1 to 0.2 mg/kg at the initial four hours; this formula could be modified to a lower dosage (0.05 mg/kg) in the post-operative management of laparoscopic cholecystectomy.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 80%

Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

Chen,

Kuo,

Chuang

et al. 2024

Medicina

View full text Add to dashboard Cite

show abstract

“…16 Similar studies have demonstrated that liquid oral analgesia has good bioavailability and can be digested by patients. 17 In fact, PCOA has been successfully implemented in a unique program at the Toronto Western Hospital, one of 3 sites comprising the University Health Network in Canada. 18 …”

Section: Discussionmentioning

confidence: 99%

A Single Center Exploratory Survey of Patients and Nurses on post-Surgical Oral Opioid Delivery Through Patient-Controlled Analgesia

Mirza,

Zha,

See

et al. 2024

JPR

View full text Add to dashboard Cite

Background The most common route of opioid delivery is nurse-administered pills. However, there are numerous challenges such as nursing burden, opioid diversion, medication delay, and patient dissatisfaction. In this study, we conducted two surveys, first to assess patients’ and nurses’ opinions on the current administration of opioids in pill form, followed by their attitudes towards an innovative concept of oral medication delivery based on a medical device currently undergoing research and development within the University, patient-controlled dispenser and deactivator (PCDD) that allows patients to self-administer liquid oral opioids on demand based on physician prescription. Methods Questionnaires were developed, verified and deployed to assess nurse and post-surgical patient opinions on the current administration of opioids in pill form, as well as the proposed new concept of patient -controlled administration of oral liquid medication via an illustration of PCDD, from September 2022 through July 2023 at a major academic tertiary care center. Quantitative and qualitative data were collected from postoperative patients and nurses from surgical specialties including General Surgery, Surgical Oncology, Trauma Surgery, Orthopedics, and Neurosurgery. Results Forty-three patients and 53 nurses were interviewed. Seventy percent of patients frequently called nurses for pain medication post-surgery 1–4 times daily, and 32% of patients were told each day by nurses that they could not receive medication because they were not due yet. Medication delay caused 24% of patients to worry about nursing availability for medication delivery. Likewise, nurses reported that half of patients receive delayed medication (22 minutes median delay time) and half of nursing time was spent administering pain medication. Nurses expressed moderate satisfaction with their current delivery of medication (median satisfaction score 6.5 out of 10). When being introduced to the concept of PCDD via a product illustration, 15% of patients said that they prefer liquid medication and 51% said they prefer PCDD or were interested in trying it. Conclusion Nurse-administered pills are a common but suboptimal method for postoperative pain management. Based on patient and nurse feedback, patient controlled self-administered liquid oral opioid delivery is conceptually innovative, practically viable and potentially a preferred alternative for timely and less nurse-exhaustive pain management.

show abstract

Réhabilitation précoce postopératoire après césarienne

Wyniecki¹,

Benhamou²

2012

Rev. med. perinat.

View full text Add to dashboard Cite

Quantifying Oral Analgesic Consumption Using a Novel Method and Comparison with Patient-Controlled Intravenous Analgesic Consumption

Cited by 19 publications

References 10 publications

Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

A Single Center Exploratory Survey of Patients and Nurses on post-Surgical Oral Opioid Delivery Through Patient-Controlled Analgesia

Réhabilitation précoce postopératoire après césarienne

Contact Info

Product

Resources

About