Quantifying teenagers’ sleep patterns and sex differences in social jetlag using at-home sleep monitoring

Hrozanova, Maria; Haugan, Jan Arvid; Saksvik‐Lehouillier, Ingvild; Skalická, Věra; Krondorf, Lukas; Stenseng, Frode; Moen, Frode

doi:10.1016/j.sleep.2023.04.005

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…Adolescent sleep health is a significant public health concern worldwide. This pattern of shortened and ill-timed sleep in adolescents and teenagers is well-documented in epidemiological research (e.g., Hrozanova et al, 2023). In terms of shortened sleep, a cross-sectional study investigating sleep patterns of adolescents in 24 European and North American countries found the proportion of adolescents not meeting sleep recommendations on school days ranged between 14% and 68% (Gariepy et al, 2020;Paruthi et al, 2016).…”

mentioning

confidence: 70%

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

Lau,

Carney

2024

Canadian Journal of Behavioural Science / Revue canadienne des

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confidence: 70%

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

Lau,

Carney

2024

Canadian Journal of Behavioural Science / Revue canadienne des

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“…Boys fell asleep later on Friday and Saturday nights. Boys had longer sleep latency, and worse sleep efficiency than girls on Saturday nights ( Hrozanova et al, 2023 ). In exploring the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and corticotropin-releasing factor (CRF) on sleep structure, the researchers found that at baseline, male mice spent more time in NREM sleep and less time in wake than female mice ( Foilb et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

The α₂ Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice

et al. 2023

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The unique sedative activities with rapid arousal of dexmedetomidine (Dex) are not fully understood. Growing evidence suggests the involvement of the ventrolateral preoptic area (VLPO) in sleep–wake cycle. The major type in the VLPO is sleep-active neurons, inhibited by noradrenaline (NA(−) neurons). The other type of neurons is activated by NA (NA(+) neurons), which are wake-active. Previous research showed that Dex-induced sedation and sleep homeostasis likely share common mechanisms. To explore the underlying mechanisms of Dex in the VLPO, in vivo polysomnography recording and in vitro electrophysiological recording were used in our study. Bath application of Dex (2 μM) increased the firing rate of both VLPO NA(−) and NA(+) neurons. Compared to the control group, there was no difference in the firing rate of both VLPO NA(−) and NA(+) neurons after Dex (2 μM) and RS79948 (1 mM) administration, an α2 receptor antagonist. No difference was detected regarding resting membrane potential (RMP) amplitude of both VLPO NA (−) and NA(+) neurons after application of Dex (2 μM). Moreover, Dex (2 μM) significantly reduced the frequency of miniature inhibitory postsynaptic currents (mIPSCs) in both VLPO NA(−) and NA(+) neurons. These electrophysiology results were consistent with behavioral sedation, with increased nonrapid eye movement sleep (NREM sleep) and increased expression of c-Fos in the VLPO during the dark phase after intraperitoneal injection with Dex (80 μg/kg). In conclusion, Dex activates NA(−) and NA(+) neurons in the VLPO via presynaptic α2 receptors. This mechanism may explain the unique sedative properties with rapid arousal. Summary Statement Dexmedetomidine is an important ICU sedative. The mechanism of dexmedetomidine is not fully understood. Activating NA(−) and NA(+) neurons in the VLPO by dexmedetomidine using polysomnography and electrophysiological recording, this may explain the unique sedative properties with rapid arousal.

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Sleep duration and social jetlag in healthy adolescents. Association with anxiety, depression, and chronotype: a pilot study

Magnusdottir,

Gunnlaugsdottir

et al. 2024

Sleep Breath

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Quantifying teenagers’ sleep patterns and sex differences in social jetlag using at-home sleep monitoring

Cited by 9 publications

References 38 publications

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

The α₂ Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice

Sleep duration and social jetlag in healthy adolescents. Association with anxiety, depression, and chronotype: a pilot study

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Quantifying teenagers’ sleep patterns and sex differences in social jetlag using at-home sleep monitoring

Cited by 9 publications

References 38 publications

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

Mapping out Canadian adolescent sleep patterns: A mixed-methods approach.

The α2 Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice

Sleep duration and social jetlag in healthy adolescents. Association with anxiety, depression, and chronotype: a pilot study

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The α₂ Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice