2006
DOI: 10.1088/0031-9155/51/14/005
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Quantifying the effect of respiratory motion on lung tumour dosimetry with the aid of a breathing phantom with deforming lungs

Abstract: The contribution of organ and tumour motion to the degradation of planned dose distributions during radiotherapy to the breathing lung has been experimentally investigated and quantified. An anthropomorphic, tissue-equivalent breathing phantom with deformable lungs has been built, in which the lung tumour can be driven in any arbitrary 3D trajectory. The trajectory is programmed into a motion controller connected to a high-precision moving platform that is connected to the tumour. The motion controller is conn… Show more

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Cited by 62 publications
(54 citation statements)
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“…This analysis confirmed the phenomenon of ''dose blurring,'' which appeared as a stretched isodose distribution in the cranio-caudal direction and as a global reduction of absorbed dose in the PTV. These observations correspond with the results of other experimental studies showing dose blurring, underdosages, and penumbral spreading of the dose distribution because of respiratory movement of the target (20,21). In our experiments, the observed CT and histopathologic findings might have been blurred because of these presumed effects.…”
Section: Issues Expected In Clinical Applicationsupporting
confidence: 92%
“…This analysis confirmed the phenomenon of ''dose blurring,'' which appeared as a stretched isodose distribution in the cranio-caudal direction and as a global reduction of absorbed dose in the PTV. These observations correspond with the results of other experimental studies showing dose blurring, underdosages, and penumbral spreading of the dose distribution because of respiratory movement of the target (20,21). In our experiments, the observed CT and histopathologic findings might have been blurred because of these presumed effects.…”
Section: Issues Expected In Clinical Applicationsupporting
confidence: 92%
“…The probe was clamped to a mechanical articulated arm, which was mounted on a three-axis of motion translational stage (Nioutsikou et al 2006). The position of the transducer was controlled by three stepper motors driven by commands from a PC.…”
Section: Experimental Set-upmentioning
confidence: 99%
“…[3][4][5][6][7][8]) or by means of planning studies making use of 4D (=3D+t) dose calculation concepts (cf. [9][10][11][12] as examples).…”
Section: Introductionmentioning
confidence: 99%