Quantifying the ‘hidden’ lactose in drugs used for the treatment of gastrointestinal conditions

Abstract

SUMMARY BackgroundLactose intolerance affects 70% of the world population and may result in abdominal and systemic symptoms. Treatment focuses predominantly on the dietary restriction of food products containing lactose. Lactose is the most common form of excipient used in drug formulations and may be overlooked when advising these patients.

NMR spectroscopy as a screening tool to validate nutrition labeling of milk, lactose-free milk, and milk substitutes based on soy and grains

“…The most frequently used technique for lactose determination in milk and dairy products is an enzymatic assay based on spectrophotometric measurement, which is also the German reference method (Amtliche Sammlung von Untersuchungsverfahren 2010). Other approaches include biosensors (Ammam and Fransaer 2010), colorimetry (Bakos et al 2002), near-infrared (NIR) spectroscopy (Kawasaki et al 2008;Woo et al 2002), Fourier transform infrared spectroscopy (Lefier et al 1996), or chromatographic techniques (Eadala et al 2009;Paredes et al 2006;Schuster-Wolff-Bühring et al 2011). Besides being comparably time-consuming, none of these methods appear to be appropriate for our purpose to provide a rapid screening of nutrition parameters.…”

Generic Drug Immunosuppression in Thoracic Transplantation: An ISHLT Educational Advisory

“…The investigators in that study discovered that some medications taken as prescribed could result in as much as 1-g or higher lactose ingestion. 15 …”

Lactose Intolerance

“…Probiotics can also reduce symptoms [ 12 ]. Patients often also take antacids and proton pump inhibitors to reduce stomach acidity and refl ux.…”