The Great Green Wall (GGW) initiative, which started in 2007 and is still in development as of 2024, aims to combat desertification and enhance sustainability over 8000 km across Africa’s Sahel-Sahara region, encompassing 11 key countries and 7 countries associated with the initiative. Because of limited ground measurements for the GGW project, the progress and impacts of the GGW initiative have been a challenging problem to monitor and assess. This study aims to utilize satellite remote sensing data to analyze changes in the key factors related to the sustainability of the GGW region, including land cover type, vegetation index, precipitation rate, land surface temperature (LST), surface soil moisture, etc. Results from temporal analysis of these factors indicate that the deserts along the GGW are retreating and the regional mean of the Normalized Difference Vegetation Index (NDVI) has an increasing trend, although the precipitation has a slightly decreasing trend, over the past two decades. Further analysis shows spatial heterogeneity of vegetation, precipitation, and soil moisture changes. Desertification is still a challenging issue in some GGW countries. These results are helpful in understanding climate change in the GGW regions and the impacts of the Great Green Wall initiative.