Brittle faults and fault zones are among the most hydraulically active elements in predominantly impermeable crystalline host rock. They pose a significant challenge to underground infrastructure like nuclear waste repositories. Brittle fault zones frequently occur along pre-existing ductile shear zones as they introduce weakness planes in the rock.Four brittle fault zones of ductile origin were analyzed in the Rotondo Granite at the “BedrettoLab” in the Swiss Central Alps. Scanline mapping, rock sampling and permeability measurements using three different methods provide detailed insights into the heterogeneous fault zone architecture and hydrogeology. Average intact rock permeability is in the range of 10−19 to 10−17 m2. Fluid flow is channeled into single open or partially mineralized fractures of, at point-scale, up to 10−14 m2, demonstrated by selective gas probe permeameter measurements and borehole hydraulic testing. Reduced permeabilities have been measured in close proximity to these permeable features, indicating alteration of and around the fracture walls.