Quantitation in Positron Emission Computed Tomography

Hoffman, Edward J.; Huang, Sung‐Cheng; Phelps, Michael E.

doi:10.1097/00004728-197906000-00001

Cited by 1,040 publications

(358 citation statements)

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“…In fact, a substantial number of cases were defined as "benign" only because the tumor did not become enlarged during the follow-up period or because the FNAB finding was negative just once. In this study we evaluated whether repeating FDGresolution of the PET scanner, known as the partial volume effect [21]. Consequently, it remains controversial whether SUVmax is useful to distinguish between benign and malignant.…”

Section: Discussionmentioning

confidence: 99%

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

et al. 2010

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Abstract. As 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is becoming a common imaging modality, the number of thyroid incidentalomas identified by FDG-PET (PET incidentaloma) is increasing. The purpose of this study was to elucidate the risk of cancer in focal thyroid PET incidentaloma in healthy subjects of relatively younger age as well as the usefulness of repeated FDG-PET. The study was conducted with an observation period of three years. A total of 1,501 healthy volunteers (mean age, 43.5±9.7 years) underwent the first FDG-PET from August 2003 to July 2004. When focal thyroid PET incidentaloma was found, further diagnostic examination was conducted. When thyroid cancer was suspected, surgical resection was performed with the patient's agreement. Patients with PET incidentaloma without surgery were offered annual US and FDG-PET and finally FNAB was performed in the fourth year. Focal thyroid PET incidentaloma was observed in 20 subjects. The final diagnoses in 20 subjects were malignant in 11 (ten papillary thyroid carcinoma (PTC) and one thyroid carcinoma showing thymus-like differentiation), indeterminate in one, and benign in eight subjects. Seven patients not treated surgically at the first examination had annual FDG-PET. One patient with PTC showed increasing SUVmax, but another with a benign nodule exhibited a similar increase. Others (one with PTC, one with an indeterminate nodule, and three with benign nodules) exhibited negligible SUVmax changes. When closely examined, focal thyroid PET incidentaloma in relatively young healthy adults has a high probability of malignancy. Repeated FDG-PET to follow up patients with thyroid nodules is ineffective.

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Section: Discussionmentioning

confidence: 99%

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

et al. 2010

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“…PVC methods can be grouped into two main categories: post-reconstruction and duringreconstruction methods. Post-reconstruction methods include the region-based methods, such as the recovery-coefficient correction [168] and the geometric transfer-matrix (GTM) method [169]. Other post-reconstruction corrections consist of voxel-based methods, such as the popular Mueller-Gaertner method (MGM) [170], image deconvolution [171], and the "region-based voxel-wise correction" (RBV) [172].…”

Section: Partial Volume Correction In Pet and Spectmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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“…PVE leads to an underestimation of the activity concentration in the PET images and spillover into surrounding tissues that is observed in objects smaller than three times the spatial resolution. In addition, image sampling where different types of tissue and thus radiotracer concentrations are included in one voxel also contributes to PVE [42][43][44]. There are several methods for partial volume correction based either on the count recovery models such as the recovery coefficient [45,46] or the contrast recovery coefficient method [47][48][49] or they are based on anatomical data (derived from MR imaging) such as the geometric transfer matrix method [50].…”

Section: Partial Volume Effectmentioning

confidence: 99%

Quantitative preclinical PET imaging: opportunities and challenges

Kuntner

Stout

2014

Front. Physics

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PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the particular science being investigated. There is no single answer, yet there are factors that are common to all experiments that are the subject of this review. From physics to physiology, there are many factors to consider, each of which can have a significant impact upon measurements of metabolism in vivo. This review examines the most common factors related to all types of quantitative PET imaging.

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Quantitation in Positron Emission Computed Tomography

Cited by 1,040 publications

References 0 publications

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

Hybrid Imaging: Instrumentation and Data Processing

Quantitative preclinical PET imaging: opportunities and challenges

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