Quantitation of immunocompetence in Hodgkin's disease.

Faguet, Guy B.

doi:10.1172/jci108175

Cited by 67 publications

(12 citation statements)

References 26 publications

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“…Depressed LP responses in cancer patients have been described in many studies (Ducos et al, 1970;Rees et al, 1975;Han and Takita, 1972;Catalona et al, 1973;Dean et al, l977,1978Dean et al, l977, ,1979aLiebler et al, 1977;Dalbrow et al, 1977;Hersh and Oppenheim, 1965;Cohnen et al, 1973;Graze et al, 1976;Faquet, 1975;MelIstedt and Holm, 1973;King et al, 1976;Matchett et al, 1973;Garrloch et al, 1970;McKhann et al, 1975;Golub et al, 1974;Whittaker et al, 1971;Weese et al, 1977). However, LP responsiveness did not always correlate well with stage of disease and therefore appeared to be independent of extent of tumor burden (Bornes et al, 1975).…”

Section: Discussionmentioning

confidence: 96%

Association of depressed postoperative lymphoproliferative responses to alloantigens with poor prognosis in patients with stage I lung cancer

Cannon

Dean

et al. 1980

Intl Journal of Cancer

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Thirty-five patients with Stage I carcinoma of the lung were tested postoperatively to assess lymphoproliferative responses. Depressed lymphocyte proliferation (LP) responses to alloantaigen in the mixed leukocyte culture (MLC) as measured by thee relative proliferation index (RPI) were associated with a significantly shorter disease-free interval. In this group of patients, the immunologic responses predicted subsequent clinical course better than the TNM classification or the histological type of the tumor, and therefore this procedure appears promising for improved staging of patients with early stages of lung cancer (stage I lung cancer and T1N0M0). The depressed response to alloantaigen was a more sensitive discriminator of disease recurrence than PHA alone or even conbined with PHA.

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Section: Discussionmentioning

confidence: 96%

Association of depressed postoperative lymphoproliferative responses to alloantigens with poor prognosis in patients with stage I lung cancer

Cannon

Dean

et al. 1980

Intl Journal of Cancer

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“…The proliferative response to anti-gens (5,6) and mitogens (3,7), especially at suboptimal mitogen concentrations (8), is often impairedl. Protein synthesis (9), mediator production (10), and cytotoxicity (11) by cultured lymphocytes are often subniormiial.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of immunodeficiencies with Hodgkin's disease.

Twomey¹,

Laughter²,

Rice³

et al. 1980

J. Clin. Invest.

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“…Although antibody responses appear to be unimpaired (1,2), patients frequently exhibit defects of T cell-mediated immune functions manifested by diminished delayed hypersensitivity responses (3)(4)(5)(6)(7), impaired ability to reject skin allografts (8)(9)(10), and decreased resistance to certain types of infection (11)(12). Several in vitro functions of peripheral blood T cells have been shown to be impaired, including the blastogenic response to soluble antigens (13)(14)(15), alloantigens (16,17), and plant lectins (2,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Some ofthese defects may be explained by the presence of suppressor monocytes (17,(28)(29)(30) and suppressor T cells (29,31).…”

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confidence: 99%