Quantitative Airway Assessment on Computed Tomography in Patients with Alpha-1 Antitrypsin Deficiency.

Yamashiro, Tsuneo; Matsuoka, Shin; Estépar, Raúl San Jośe; Diaz, Alfredo Peña; Sandhaus, RA; Mergo, Patricia J.; Brantly, ML; Murayama, Sadayuki; Reilly, JJ; Hatabu, Hiroto; Silverman, EK; Washko, G.R.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5592

Cited by 2 publications

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“…Very recently, this stronger correlation of bronchial measurements of more distal bronchi with FEV 1 %predicted was also found in AATD patients. 7 We hypothesized that severity of emphysema could influence the distensibility of bronchi, because lung tissue is lost during emphysema progression. Therefore, the presence of more emphysema may induce less distensibility of the bronchus located in that region, because of loss of elastic recoil.…”

Section: Bronchial Measurements Versus Lung Functionmentioning

confidence: 99%

Influence of inspiration level on bronchial lumen measurements with computed tomography

Bakker

Stolk

Reiber

et al. 2012

Respiratory Medicine

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Section: Bronchial Measurements Versus Lung Functionmentioning

confidence: 99%

Influence of inspiration level on bronchial lumen measurements with computed tomography

Bakker

Stolk

Reiber

et al. 2012

Respiratory Medicine

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“…In a normal population including never-smokers, differences in percent emphysema may occur because of altered stretch or compression of the lung related to gravity, height of the lung and support of the heart (1,25), variation in residual peripheral airway structures (a voxel inside an airway will be emphysema-like), and scatter effects (26), which differ by scanner manufacturer, or may represent the presence of subclinical emphysema due to secondhand smoke exposure during childhood and other environmental exposures, as well as genetic factors (27)(28)(29)(30)(31)(32). Indeed, researchers in small studies have suggested that percent emphysema varies among healthy never-smokers by demographic factors (33)(34)(35)(36); however, these studies were limited by modest sample sizes, restricted racial and ethnic distributions, and lack of population-based sampling.…”

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confidence: 99%

Variation in the Percent of Emphysema-like Lung in a Healthy, Nonsmoking Multiethnic Sample. The MESA Lung Study

Hoffman

Ahmed²,

Baumhauer³

et al. 2014

Annals ATS

107

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Rationale: Computed tomography (CT)-based lung density is used to quantitate the percentage of emphysema-like lung (hereafter referred to as percent emphysema), but information on its distribution among healthy nonsmokers is limited.Objectives: We evaluated percent emphysema and total lung volume on CT scans of healthy never-smokers in a multiethnic, population-based study. Methods:The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study investigators acquired full-lung CT scans of 3,137 participants (ages 54-93 yr) between 2010-12. The CT scans were taken at full inspiration following the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) protocol. "Healthy never-smokers" were defined as participants without a history of tobacco smoking or respiratory symptoms and disease. "Percent emphysema" was defined as the percentage of lung voxels below 2950 Hounsfield units. "Total lung volume" was defined by the volume of lung voxels.Measurements and Main Results: Among 854 healthy neversmokers, the median percent emphysema visualized on full-lung scans was 1.1% (interquartile range, 0.5-2.5%). The percent emphysema values were 1.2 percentage points higher among men compared with women and 0.7, 1.2, and 1.2 percentage points lower among African Americans, Hispanics, and Asians compared with whites, respectively (P , 0.001). Percent emphysema was positively related to age and height and inversely related to body mass index. The findings were similar for total lung volume on CT scans and for percent emphysema defined at 2910 Hounsfield units and measured on cardiac scans. Reference equations to account for these differences are presented for never, former and current smokers.Conclusions: Similar to lung function, percent emphysema varies substantially by demographic factors and body size among healthy never-smokers. The presented reference equations will assist in defining abnormal values for percent emphysema and total lung volume on CT scans, although validation is pending.

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Quantitative Airway Assessment on Computed Tomography in Patients with Alpha-1 Antitrypsin Deficiency.

Cited by 2 publications

References 0 publications

Influence of inspiration level on bronchial lumen measurements with computed tomography

Influence of inspiration level on bronchial lumen measurements with computed tomography

Variation in the Percent of Emphysema-like Lung in a Healthy, Nonsmoking Multiethnic Sample. The MESA Lung Study

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