Quantitative Analysis of Acetazolamide in Solid Dosage Forms with<sup>1</sup>H-Nmr Spectroscopy

Şenyuva, Hamide Z.; Özden, Tuncel; Akşahın, İnci

doi:10.1080/00387010009350148

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The preferred technique is high-performance liquid chromatography (HPLC) because of its high selectivity and sensitivity. Few methods have been proposed for analysis of this drug in pharmaceutical dosage forms [30][31][32][33][34].…”

Section: Acetazolamidementioning

confidence: 99%

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Ihssane¹,

Charrouf²,

Abourriche³

et al. 2011

Acta Chromatographica

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This paper describes the optimization and validation of an analytical method for HPLC analysis of acetazolamide in tablets using Box-Behnken design. This multivariate approach enables substantial improvement of chromatographic performance using fewer experiments, without additional cost of columns or other equipment. By use of quadratic regression analysis, equations were developed describing the behavior of the response as simultaneous functions of the selected independent variables. Accordingly, the optimum conditions were determined. For quality-control samples these were use of a C 18 column with acetonitrile-phosphoric acid buffer solution (0.01 M, pH 7.1) 15:85 (v/v) as mobile phase at a flow rate of 1.0 mL min −1 . Diode-array detection was performed at 266 nm. The method was validated, in accordance with ICH guidelines, for accuracy, precision (intra-day and inter-day coefficient of variation <2.0%), selectivity, and linearity (R² = 0.9993) over the concentration range 10-300 μg mL −1 . The method is simple, rapid, sensitive, and accurate and the retention time is less than 4 min. The method is therefore suitable for routine quality-control monitoring of acetazolamide in tablets.

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Section: Acetazolamidementioning

confidence: 99%

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Ihssane¹,

Charrouf²,

Abourriche³

et al. 2011

Acta Chromatographica

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Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Şenyuva

Akşahın

Özcan

et al. 2005

Analytica Chimica Acta

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Application of Box-Behnken design and desirability function in the optimization of spectrophotometric method for the quantification of WADA banned drug: Acetazolamide

Rahman

Sameen

Kashif

2019

Journal of Molecular Liquids

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Quantitative Analysis of Acetazolamide in Solid Dosage Forms with¹H-Nmr Spectroscopy

Cited by 3 publications

References 3 publications

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Application of Box-Behnken design and desirability function in the optimization of spectrophotometric method for the quantification of WADA banned drug: Acetazolamide

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Quantitative Analysis of Acetazolamide in Solid Dosage Forms with1H-Nmr Spectroscopy

Cited by 3 publications

References 3 publications

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Application of Box-Behnken design and desirability function in the optimization of spectrophotometric method for the quantification of WADA banned drug: Acetazolamide

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Quantitative Analysis of Acetazolamide in Solid Dosage Forms with¹H-Nmr Spectroscopy