Quantitative Analysis of Changes in Macular Layers Following Optic Neuritis

Tegetmeyer, Helmut; Kühn, Elisabeth

doi:10.3109/01658107.2011.580885

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…However, recent studies have shown that also macular thickness and volume are decreased in the eyes of patients with MS [6], [7], [12]–[14], presumably caused by the thinning of the ganglion cell layer (GCL) and inner plexiform layer (IPL) [11], [15]–[17].…”

Section: Introductionmentioning

confidence: 99%

“…The loss of retinal nerve fibers around the optic disc (circumpapillary RNFL – cpRNFL) has been found in the eyes of MS patients both with and without optic neuritis (ON) in the history [6] – [11] . However, recent studies have shown that also macular thickness and volume are decreased in the eyes of patients with MS [6] , [7] , [12] – [14] , presumably caused by the thinning of the ganglion cell layer (GCL) and inner plexiform layer (IPL) [11] , [15] – [17] .…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

et al. 2012

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ObjectiveTo evaluate macular morphology in the eyes of patients with multiple sclerosis (MS) with or without optic neuritis (ON) in previous history.MethodsOptical coherence tomography (OCT) examination was performed in thirty-nine patients with MS and in thirty-three healthy subjects. The raw macular OCT data were processed using OCTRIMA software. The circumpapillary retinal nerve fiber layer (RNFL) thickness and the weighted mean thickness of the total retina and 6 intraretinal layers were obtained for each eye. The eyes of MS patients were divided into a group of 39 ON-affected eyes, and into a group of 34 eyes with no history of ON for the statistical analyses. Receiver operating characteristic (ROC) curves were constructed to determine which parameter can discriminate best between the non-affected group and controls.ResultsThe circumpapillary RNFL thickness was significantly decreased in the non-affected eyes compared to controls group only in the temporal quadrant (p = 0.001) while it was decreased in the affected eyes of the MS patients in all quadrants compared to the non-affected eyes (p<0.05 in each comparison). The thickness of the total retina, RNFL, ganglion cell layer and inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, comprising the RNFL and GCL+IPL) in the macula was significantly decreased in the non-affected eyes compared to controls (p<0.05 for each comparison) and in the ON-affected eyes compared to the non-affected eyes (p<0.001 for each comparison). The largest area under the ROC curve (0.892) was obtained for the weighted mean thickness of the GCC. The EDSS score showed the strongest correlation with the GCL+IPL and GCC thickness (p = 0.007, r = 0.43 for both variables).ConclusionsThinning of the inner retinal layers is present in eyes of MS patients regardless of previous ON. Macular OCT image segmentation might provide a better insight into the pathology of neuronal loss and could therefore play an important role in the diagnosis and follow-up of patients with MS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

et al. 2012

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“…Similar results have been shown in the previous studies. 8,16,17 Also, baseline FLV and GLV values significantly increased in MS patients compared with controls. FLV and GLV parameters have not been investigated in the similar studies.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Huseyinoglu¹,

Özben²,

Ekinci

et al. 2013

Neuro-Ophthalmology

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Optical coherence tomography is supported and used as a technique for visualisation of neuro-axonal loss in multiple sclerosis, but there are also a few studies expressing the opposite view. The aim of our study was to investigate retinal nerve fibre layer and optic nerve head parameters in patients with multiple sclerosis without a history of prior optic neuritis and symptoms of a new clinical attack during the follow-up for a total of 20-month period. Full ophthalmic evaluation was performed for all of the participants. The baseline retinal nerve fibre layer and macular thicknesses and focal and global loss of macular volume values were significantly lower in the eyes of the patients with multiple sclerosis compared with the healthy controls. No significant change between baseline and follow-up scans were found in all optical coherence tomography parameters in the multiple sclerosis group. Statistical analyses revealed significant retinal nerve fibre layer and macular thickness differences between baseline and second measurements in the controls. No significant difference in percent change between baseline and second measurements was observed between the patient and control groups. We conclude that whereas healthy subjects have an age-related tendency toward a decrease in retinal nerve fibre layer thickness, patients with multiple sclerosis patients are likely to pass through different stages of retinal thinning and thickening due to subclinical optic neuritis and, as a result, we could not detect any statistically significant change between baseline and second measurements in our multiple sclerosis patients.

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“…OCT imaging of these patients allows evaluation of the extent of damage due to ON and monitoring the progress of ON. [6] The prevalence of MS is rising in the Gulf countries. It is linked to vitamin D deficiency and high consanguinity in the region.…”

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confidence: 99%

Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes

Lotfy

Alasbali

Khandekar

2019

Indian J Ophthalmol

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Purpose: To compare different macular thickness parameters and peripapillary retinal nerve fiber layer (RNFL) thickness between recently diagnosed cases of multiple sclerosis (MS) without optic neuropathy (ON) and healthy individuals. Methods: This cross-sectional study was performed between June 2014 and June 2015. All subjects underwent ocular and retinal examination. Spectral domain optical coherence tomography (SD-OCT) was used to measure the thickness of different layers of the retina at macular and peripapillary regions and at different quadrants. Between groups comparison was performed with P < 0.05 indicating statistical significance. Results: There were 32 eyes in the MS group and 74 eyes in the control group. The MS group was significantly younger than the control group ( P < 0.001). The mean ganglion cell complex (GCL++) thickness in superior macular area was 64.1 ± 8.9 μ in the MS group and 71.1 ± 5.9 μ in the control group. The thickness of the RNFL did not statistically differ in each of the quadrants between groups. Despite controlling for age, the macular thickness parameters were significantly thinner in eyes with MS compared to healthy eyes ( P < 0.01). Conclusion: The macular ganglion cell complex (mGCC) parameters were significantly reduced in recently diagnosed cases of MS as compared to healthy individuals.

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Quantitative Analysis of Changes in Macular Layers Following Optic Neuritis

Cited by 7 publications

References 26 publications

In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes

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