Quantitative Analysis of Metabolic Abnormality Associated with Brain Developmental Venous Anomalies

Abstract

Background and Purpose: Abnormal hypometabolism is common in the brain parenchyma surrounding developmental venous anomalies (DVAs), although the degree of DVA-associated hypometabolism (DVAAh) has not been quantitatively analyzed. In this study, we demonstrate a simple method for the measurement of DVAAh and test the hypothesis that DVAs are associated with a quantifiable decrement in metabolic activity.Materials and Methods: Measurements of DVAAh using ratios of standardized uptake values (SUVs) and comparison to a normal database were performed on a cohort of 25 patients (12 male, 13 female), 14 to 76 years old, with a total of 28 DVAs (20 with DVAAh, seven with isometabolic activity, and one with hypermetabolic activity).Results: Qualitative classification of none, mild, moderate, and severe DVAAh corresponded to quantitative measurements of DVAAh of 1 ± 3%, 12 ± 7%, 18 ± 6%, and 37 ± 6%, respectively. A statistically significant linear correlation between DVAAh and age was observed (P = 0.003), with a 3% reduction in metabolic activity per decade. A statistically significant linear correlation between DVAAh and DVA size was observed (P = 0.01), with a 4% reduction in metabolic activity per each 1 cm in the longest dimension. The SUVDVA-based measures of DVAAh correlated (P = 0.001) with measures derived from comparison with a standardized database.Conclusion: We present a simple method for the quantitative measurement of DVAAh using ratios of SUVs, and find that this quantitative analysis is consistent with a qualitative classification. We find that 54% (15 of 28) of DVAs are associated with a greater than 10% decrease in metabolic activity.

Quantitative positron emission tomography–guided magnetic resonance imaging postprocessing in magnetic resonance imaging–negative epilepsies

“…QPET analysis was performed using the Syngo.via software (VB10B; Siemens) . The attenuation‐corrected PET images were first fused with CT via rigid registration and then aligned to a scanner‐specific normal database using deformable registration.…”

“…QPET analysis was performed using the Syngo.via software (VB10B; Siemens). [26][27][28] The attenuation-corrected PET images were first fused with CT via rigid registration and then aligned to a scanner-specific normal database using deformable registration. The PET images were subsequently smoothed using a 12-mm full-width half-maximum isotropic Gaussian kernel to reduce the effect of image noise and nonphysiological intensity variance due to reconstruction.…”

Metabolic syndrome and hemorrhagic stroke among symptomatic CCMs in the Mexican Hispanic Population

“…Evidence indicated that fCCM patients with deficient CCMs proteins, specifically those with CCM1 gene deficiency, have exhibited disrupted metabolic function, which usually leads to oxidative stress and inflammatory response (18)(19)(20)(21). Developmental venous anomalies (DVAs), which are highly associated with sCCMs (22)(23)(24)(25), have also been linked to MetS (26)(27)(28). However, only a few and inconsistent results have been published regarding the association between MetS and hemorrhagic CCMs (29,30).…”

Developmental Venous Anomaly Presenting with Spontaneous Intracerebral Hemorrhage, Acute Ischemic Stroke, and Seizure

“…EEG monitoring in our patient showed severe diffuse encephalopathy with slowing predominantly in the left hemisphere suggestive of decreased cerebral blood flow due to restricted venous outflow [7]. The episodes of worsening right-sided weakness during the initial hospitalization with no epileptiform discharges in EEG might be due to progressive ischemia and hypometabolism from venous congestion [8-9].…”

“…Functional studies, such as single positron emission computerized tomography (SPECT), may demonstrate hypometabolism around the DVAs. These findings are suggestive of decreased outflow and venous congestion [8-9].…”