Quantitative analysis of palladacycle-tagged PLGA nanoparticle biodistribution in rat organs by means of atomic absorption spectrometry and inductively coupled plasma mass spectrometry

Abstract

A In the present study, the biodistribution of the PLGA nanoparticles labelled with Pd in form of a dimeric cyclopalladated derivative of N,N-dimethyl-diphenylmethylamine (PLGA/Pd NPs) was investigated in rats using...

FericipXT-coated PEGylated rutile TiO2 nanoparticles in drug delivery: in vitro assessment of imatinib release

“… 37 In the present study, the PEGylated NPs showed the most sustained drug release behaviour than T and F under acidic and neutral pH conditions. Kumskova et al 38 reported that polymers of different molecular weights affect the different parameters of the drug-loaded NPs such as percent drug loading, pattern of drug release and degradation of the NPs. Jain et al 29 reported the initial burst release of DOX from PEGylated CdSe/ZnS core–shell NPs in the first 180 minutes of the drug-release study followed by slower and sustained release of the drug.…”

FericipXT-Coated PEGylated Rutile TiO2 Nanoparticles in Drug Delivery: In-vitro Assessment of Imatinib Release

“…In the present study, the PEGylated NPs showed the most sustained drug release behaviour than T and F under acidic and neutral pH conditions. Kumskova et al [34] reported that polymers of different molecular weights affect the different parameters of the drugloaded NPs such as percent drug loading, pattern of drug release and degradation of the NPs. Jain et al [25] reported initial burst release of DOX from PEGylated CdSe/ZnS core-shell NPs in the rst 180 minutes of the drug-release study followed by slower and sustained release of the drug.…”

PLGA-Gold Nanocomposite: Preparation and Biomedical Applications

“…ICP-MS was used to evaluate the biological distribution of pharmaceutical polymeric carriers loaded with metal-based anticancer therapeutics (e.g., cisplatin) or tagged with metal-based molecular probes. Among the few available examples, PLGA nanoparticle distribution into vital organs in rats after intravenous administration was quantified using ICP-MS upon labeling with palladacycles (pallidum-containing) tags [ 43 ]. We have reported on the efficient encapsulation of GNP into PLGA, in which we used ICP-MS to determine the average number of encapsulated GNP per single PLGA nanocarrier which was then used to determine the number of PLGA nanoparticles per cell utilizing the low detection limit of ICP-MS analysis for gold [ 28 ].…”