Quantitative analysis of retinal microcirculation in optical coherence tomography angiography in cases with Behçet’s disease without ocular involvement

Çömez, Ayşegül; Beyoğlu, Abdullah; Karaküçük, Yalçın

doi:10.1007/s10792-018-1059-z

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…In comparison, OCTA is a non-invasive and transformative imaging technique that can quantify the retinal and disc microcirculation rapidly and accurately down to the capillary level ( 10 ). Furthermore, OCTA can reveal the retinal vascular structure layer by layer, which provides micromesh information about structural damage ( 11 ). Combined with structural optical coherence tomography ( 12 ), OCTA enables a more comprehensive understanding of vascular abnormalities in some eye diseases, including diabetic retinopathy ( 13 ), glaucoma ( 14 , 15 ), age-related macular degeneration ( 16 ), retinal vein obstruction ( 17 , 18 ), and Vogt-Koyanagi-Harada disease ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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Purpose: To investigate the involvement of peripapillary zone vascular abnormalities in Behcet's uveitis (BU) and associated visual dysfunction. We evaluated the retinal and choroidal microvascular features in both macular and peripapillary areas of BU patients to identify vascular abnormalities contributing to reduced best-corrected visual acuity (BCVA) using optical coherence tomography angiography (OCTA).Methods: A prospective, observational study was conducted in 24 eyes of 13 patients with BU and 24 eyes of 15 healthy participants as controls. They received a standard eye examination and were recorded by OCTA measurements of macular and peripapillary areas. The vascular densities of superficial capillary plexus (SCP) and deep capillary plexus (DCP), choroidal flow area, radial peripapillary capillary network (RPCN) density, foveal avascular zone (FAZ) area and perimeter, full retinal thickness (FRT), and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured.Correlations among microvascular, structural, and functional changes were assessed.Results: Our findings uncovered that the vascular density was significantly reduced in the peripapillary zone of BU eyes compared to healthy eyes, especially in the inferior subfield of the RPCN. The vascular densities of SCP and DCP quadrants within the macular zone had no significant difference between BU and control groups except for DCP density of the nasal parafoveal quadrant. Both FAZ area and perimeter were greater but without statistical significance in the BU group. Compared to healthy eyes, the choriocapillaris flow area was smaller while the FRT and pRNFLT were greater in the BU group. Notably, there was a significant correlation between the reduction in RPCN vascular density and decreased BCVA in BU patients.Conclusion: Based on OCTA, vascular changes associated with BU are more prominent in the peripapillary zone than those in the macular zone. The vascular density of the RPCN could serve as a sensitive indicator to monitoring BU pathogenic progression and treatment response using a non-invasively method of OCTA.

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Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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“…FA is considered the main diagnostic exam in these cases to show zones with no-perfusion [4,7,8,13]. In our case, FA was also helpful to identify transmission defects compatible with RPE atrophy and active inflammation around the optic nerve in late stages in the OS.…”

Section: Case Presentationmentioning

confidence: 59%

“…It is interesting to consider that few reports have shown retinal microvasculature alterations in patients with BD diagnosis. Still, with no evident ocular affection [9,12,13], this could indicate that posterior segment vessels are affected simultaneously with other organs. This could indicate that posterior segment vessels are affected simultaneously with other organs because its manifestations are the result of a chronic progressive process, being its expression unpredictable at ocular level.…”

Section: Case Presentationmentioning

confidence: 99%

“…Swept-source optical coherence tomography angiography (SS-OCTA) is a novel non-invasive imaging technique that provides highly detailed cross-sectioned structural imaging of the retinal capillary anatomy separating the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris [4,8,10,12,13]. It works through contrast blood movement images generating instantaneous angiographic-like pictures based on different sequential slices of optical coherence tomography (OCT) taken in the same cross-section (B-scan) and delivers 3-dimensional information about the structures of retinal vasculature to construct a map of blood flow [14,15].…”

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confidence: 99%

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Swept-source optical coherence tomography angiography findings in a patient with Behçet’s disease: a case report

Bueso-Ponce¹,

Rivera-Valdivia²,

Salgado-Cerrate³

et al. 2021

Ophthalmol J

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Behçet's disease (BD), also known as "silk road disease" [1], was first described in 1937 [2]. This multisystemic rheumatologic disease is characterized by necrotizing, chronic, and occlusive vasculitis, of unknown cause, which affects arteries and veins, with recurrent self-limited episodes [1-3]. Classically it presents with a triad of oral aphthous ulcers, genital ulcers, and uveitis. Nevertheless, it can also compromise other systems and organs less frequently, such as the central nervous system, cardiovascular, skin, gastrointestinal, renal, pulmonary, and musculoskeletal systems [1][2][3][4].

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“…Furthermore, several recent publications analyzed with interest changes in retinal microvascularization in BD patients without uveitis, before the emergence of evident clinical findings. Parafoveal microvasculature seems to be involved in BD patients with uveitis and in BD patients without uveitis [ 34 , 35 , 36 , 37 ]; likewise, peripapillary microvascular changes could be detected by OCTA in BD patients without clinical ocular involvement [ 38 ]. FA was performed to ensure absence of any vascular leakage or subclinical vasculitis [ 34 ].…”

Section: Diagnosis Of Uveitis Associated With Behçet’s Diseasementioning

confidence: 99%

Old and New Challenges in Uveitis Associated with Behçet’s Disease

Gueudry

Leclercq

Saadoun

et al. 2021

JCM

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Behçet’s disease (BD) is a systemic vasculitis disease of unknown origin occurring in young people, which can be venous, arterial or both, classically occlusive. Ocular involvement is particularly frequent and severe; vascular occlusion secondary to retinal vasculitis may lead to rapid and severe loss of vision. Biologics have transformed the management of intraocular inflammation. However, the diagnosis of BD is still a major challenge. In the absence of a reliable biological marker, diagnosis is based on clinical diagnostic criteria and may be delayed after the appearance of the onset sign. However, therapeutic management of BD needs to be introduced early in order to control inflammation, to preserve visual function and to limit irreversible structural damage. The aim of this review is to provide current data on how innovations in clinical evaluation, investigations and treatments were able to improve the prognosis of uveitis associated with BD.

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Quantitative analysis of retinal microcirculation in optical coherence tomography angiography in cases with Behçet’s disease without ocular involvement

Cited by 23 publications

References 25 publications

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Swept-source optical coherence tomography angiography findings in a patient with Behçet’s disease: a case report

Old and New Challenges in Uveitis Associated with Behçet’s Disease

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