Quantitative analysis of susceptibility-weighted magnetic resonance imaging in chronic hepatitis in rats

Staging liver fibrosis on multiparametric MRI in a rabbit model with elastography, susceptibility-weighted imaging and T1ρ imaging: a preliminary study

“…Hoodeshenas et al. (20) found that iron overload is the most common cause of failure of MRE in LF staging due to a low liver signal result from the iron deposition; therefore, the lower diagnostic performance of the LS value in staging F0 vs. F1 and F1 vs. F2 in our study was mainly related to the confounding factor of iron deposition (21,25,26).…”

“…Similarly, Cai et al. (30) also revealed high diagnostic performance for staging advanced LF stages and a negative correlation between SIR values and LF stages ( r = –0.68). Our study demonstrated that the SIR values decreased in parallel with the increasing LF stage, which is consistent with the previous results reported above, thus indicating that SWI might be used as an alternative imaging method to assess the severity of LF.…”

“…Conversely, Cai et al. (30) demonstrated that SIR values had a low correlation with liver steatosis ( r = 0.30) and no meaningful correlation with inflammation; therefore, further high-quality studies may be needed to investigate the relationship between SIR values and inflammation, as well as liver steatosis.…”

“…Third, a rabbit model induced by CCl 4 may not accurately reflect the pathologic change of human liver; therefore, further studies in the clinical setting are needed to confirm the findings of this study. Finally, the histopathological results of LF were heterogeneous and presented with necrotic inflammation, steatosis, fat content and iron deposition, and the heterogeneity of LF (22,30,36) may have affected the correlation between quantitative parameters (LS, T1ρ, and SIR) and various LF stages, but these heterogeneous factors cannot be measured on the common H&E and Masson’s trichrome staining. Therefore, larger studies are needed to establish the robustness of the three quantitative parameters (LS, SIR, and T1ρ) for assessing LF stage, with corrections applied for inflammation, iron, and fat in the liver.…”

MRI‐Based Radiomics Models Developed With Features of the Whole Liver and Right Liver Lobe: Assessment of Hepatic Inflammatory Activity in Chronic Hepatic Disease

“…Visual assessments of the number and size of enlarged perihepatic lymph nodes and abnormal signal characteristics of liver parenchyma allow for the evaluation of moderate‐to‐severe HIA 13,14 . Furthermore, preliminary reports have suggested the potential value of specialized quantitative MRI techniques, such as diffusion‐weighted imaging (DWI), susceptibility‐weighted imaging (SWI), diffusion kurtosis imaging (DKI), and others, in assessing HIA 15–18 . However, these methods have not yet been standardized and are limited by visual evaluation or a single quantitative parameter, which may not be sufficient and objective for the assessment of HIA.…”