Quantitative analysis of the role of nanohydroxyapatite (nHA) on 3D-printed PCL/nHA composite scaffolds

Kim, Myoung Hwan; Yun, Chulhee; Chalisserry, Elna Paul; Lee, Yong Wook; Kang, Hyun Wook; Park, Sang-Hyug; Jung, Won‐Kyo; Oh, Junghwan; Nam, Seung Yun

doi:10.1016/j.matlet.2018.03.025

Cited by 49 publications

(22 citation statements)

References 12 publications

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“…Synthetic polymers have been used extensively with HAp to print HAp-based scaffolds due to their easy structural manipulability, flexibility, and versatile mechanical performances. In the recent times, several studies involving HAp with poly(L-lactide) (PLA) (Russias et al, 2007;Ronca et al, 2013;Liu et al, 2016), poly(lactide-co-glycolide) (PLGA), poly(epsilon-caprolactone) (PCL) (Russias et al, 2007;Yao et al, 2015;Gómez-Lizárraga et al, 2017;Kim et al, 2018;Vella et al, 2018), and poly(propylene fumarate) (PPF) (Lee et al, 2009;Trachtenberg et al, 2016Trachtenberg et al, , 2017 have been reported in the literature. Russias et al produced PLA or PCL/HAp (70 wt-%) as hybrid organic/inorganic scaffolding constructs with controlled porous microstructures using robotic-assisted deposition (3D inks, Stillwater, OK, USA) at room temperature.…”

Section: Hap/synthetic Polymer-based Materialsmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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Section: Hap/synthetic Polymer-based Materialsmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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“…Despite material related advances, most of previously published reports focus only on the material synthesis and printability, and the structural characterization of the scaffold, [24–26, 28–30] while their biological properties are poorly characterized. [31, 32]…”

Section: Introductionmentioning

confidence: 99%

Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

Cámara-Torres

Sinha

Sánchez³

et al. 2021

Preprint

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The field of bone tissue engineering seeks to mimic the bone extracellular matrix composition, balancing the organic and inorganic components. In this regard, additive manufacturing (AM) of highly loaded polymer-calcium phosphate (CaP) composites holds great promise towards the design of bioactive scaffolds. Yet, the biological performance of such scaffolds is still poorly characterized. In this study, melt extrusion AM (ME-AM) was used to fabricate poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT)-nanohydroxyapatite (nHA) scaffolds with up to 45 wt% nHA, which presented significantly enhanced compressive mechanical properties, to evaluate their in vitro osteogenic potential as a function of nHA content. While osteogenic gene upregulation and matrix mineralization were observed on all scaffold types when cultured in osteogenic media, human mesenchymal stromal cells did not present an explicitly clear osteogenic phenotype, within the evaluated timeframe, in basic media cultures (i.e. without osteogenic factors). Yet, due to the adsorption of calcium and inorganic phosphate ions from cell culture media and simulated body fluid, the formation of a CaP layer was observed on PEOT/PBT-nHA 45 wt% scaffolds, which is hypothesized to account for their osteoinductivity in the long term in vitro, and osteoconductivity in vivo.

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“…Polymer and ceramic are usually combined to make a compromise between the insufficient rigidity of the polymer caused mechanical instability, and the brittleness of the ceramic caused fracture. However, other characteristics such as hydrophobicity, low cell adhesion site, and little biological interactions of some polymers like polycaprolactone (PCL), also, can be modified by adding a ceramic like nano-sized hydroxyapatite (HA) [99]. Polymers and biodegradable metals including poly-L-lactic acid (PLLA) and magnesium (Mg), can also make composites to provide desired biodegradability rate and at the same time higher strength and structural integrity [100].…”

Section: Advanced Materialsmentioning

confidence: 99%

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

162

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Background Bones in human body are prone to damage due to different causes such as fractures, diseases, and infections. Nevertheless, they have a remarkable capacity to repair and heal themselves after trauma and illness. Large defects, however, are never completely reinstated because their sizes are beyond the limit up to which the bones can repair [1]. In these conditions, therefore, a medical remedy is required to stabilize, align and support the damaged bone region to restore the lost function. Bone autografts are considered the gold standard treatment. However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [2, 3]. Therefore, the research has headed for other solutions via tissue engineering. Bone tissue engineering provides three-dimensional (3D)

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Quantitative analysis of the role of nanohydroxyapatite (nHA) on 3D-printed PCL/nHA composite scaffolds

Cited by 49 publications

References 12 publications

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

Challenges on optimization of 3D-printed bone scaffolds

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