Quantitative anatomy of the primary ossification center in the fetal pubis bone

Abstract

Purposes Skeletodysplasiae and hereditary dysostoses constitute a group of over 350 disorders of the skeletal system. Knowledge about development of the pubic primary ossification center may be useful in both determining the fetal stage and maturity, and for detecting congenital disorders. The present study was performed to quantitatively examine the pubic primary ossification center with respect to its linear, planar, and volumetric parameters. Materials and methods Using methods of computed tomography (CT), digital-image analysis and statistics, the size of the pubic primary ossification center in 33 spontaneously aborted human fetuses (18 males and 15 females) aged 22–30 weeks was studied. Results With no sex and laterality differences, the best-fit growth dynamics for the pubic primary ossification center was modeled by the following functions: y = − 13.694 + 0.728 × age ± 0.356 for its sagittal diameter, y = − 3.350 + 0.218 × age ± 0.159 for its vertical diameter, y = − 61.415 + 2.828 × age ± 1.519 for its projection surface area, and y = − 65.801 + 3.173 × age ± 2.149 for its volume. Conclusions The size of the pubic primary ossification center shows neither sex nor laterality differences. The growth dynamics of the vertical and sagittal diameters, projection surface area, and volume of the pubic ossification centers follow proportionately to fetal age. The obtained numerical findings of the pubic ossification center are considered age-specific reference data with clinical implications in the diagnostics of congenital defects.

Pubic bone ossification at birth in normal and preterm neonates

“…Radiography was used to evaluate the pubic bone in this study. Diseases causing abnormality and delay of ossification in the pubic bone include endocrine disorders, chromosomal disorders and bone dysplasia 4 . Computed tomography and magnetic resonance imaging provide more detailed information on both the ossification centers and the unossified cartilage than radiographs 4,5 .…”

“…Diseases causing abnormality and delay of ossification in the pubic bone include endocrine disorders, chromosomal disorders and bone dysplasia 4 . Computed tomography and magnetic resonance imaging provide more detailed information on both the ossification centers and the unossified cartilage than radiographs 4,5 . These modalities should therefore be used in studies in the future because they may provide more detailed information about the pubic bone than radiography 4,5 …”

Ontology of Congenital Malformations of Pelvic Bone

“…Зрощення первинних центрів скостеніння тазової кістки спочатку відбувається між сідничою та лобковою кістками. При народженні лобкова кістка ще відокремлена від сідничої кістки хрящем у вигляді сідничо-лобкового синхондрозу [11].…”

“…Генералізовані УВР кульшових кісток призводять до зміни конфігурації цілого тазу, а ізольовані -стосуються однієї кістки чи її частини. Генералізовані УВР кісток тазу пов'язують з ендокринними та хронічними захворюваннями матері, випадками гіпотрофії та хромосомними абераціями [1][2]11].…”

“…При клейдокраніальній дисплазії уповільнене скостеніння частіше вражає лобкову кістку, а при сіднично-вертебральній дисплазії -сідничу. Тип успадкування -автосомно-домінантний [11].…”