Quantitative aspects of placental structure

Aherne, W.; Dunnill, M. S.

doi:10.1002/path.1700910117

Cited by 191 publications

(74 citation statements)

References 18 publications

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“…This is similar to the observation of Boyd and Scott 14 and Teasdale 12 . Similar findings were also described by Aherne and Dunnill 15 where volume of hypertensive placenta was significantly lower than the normal value at term.…”

Section: Number Of Cotyledonssupporting

confidence: 90%

Morphological Changes of Placenta in Preeclampsia

et al. 1970

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Context: Preeclampsia is regarded as a risk factor in pregnancy and it leads to placental insufficiency. This, in turn causes both maternal and fetal morbidity and mortality. The present study intends to compare the morphological changes of placenta in preeclampsia with that of normal placenta. Study design: A descriptive type of study. Place and period of study: Department of Anatomy, Dhaka Medical College, Dhaka, from August 2005 to June 2006. Materials: 60 human placentae, 30 were from normal pregnant women as control and 30 from pregnancies complicated by preeclampsia were taken for this study. Method: Samples were grouped as Group A and Group B on the basis of presence or absence of preeclampsia. All samples were studied morphologically. Result: Different shapes of placenta were found with some having accessory lobes in both groups. There was significant reduction (p< 0.001) in diameter and volume of placenta in Group B. The thickness of placenta was reduced in Group B but the difference did not reach a significant level. The number of cotyledon was significantly reduced in Group B (p<0.05). Conclusion: In this study, it was found that the preeclamptic placentae underwent definite morphological changes. These changes seemed to be the result of insufficiency of placenta in preeclampsia. However, further histological and morphometric placental study in a larger sample has to be conducted to come up with a conclusive decision. Key Words: Placenta, Preeclampsia, Morphology. doi: 10.3329/bja.v7i1.3026 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 49-54

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Section: Number Of Cotyledonssupporting

confidence: 90%

Morphological Changes of Placenta in Preeclampsia

et al. 1970

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“…A linear correlation was reported between the surface area of the placental villi and the fetal body weight (Aherne and Dunnill 1966).. The increased surface area of villi in diabetes was attributed to villous hyper-ramifications (Bjork and Persson 1984 ;Boyd et al 1986 ) and was associated with variations in blood glucose levels (Madsen 1986).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Investigations of Placental Terminal Villi in Maternal Diabetes Mellitus by Scanning and Transmission Electron Microscopy.

Honda

Toyoda

Nakabayashi

et al. 1992

Tohoku J. Exp. Med.

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The structure of the terminal villi was observed in placentae from non-diabetic mothers and mothers with diabetes mellitus using scanning and transmission electron microscopy. The metabolic condition of maternal diabetes was tightly controlled. In the diabetic group, the diameter of the terminal villi was significantly smaller than in the control group. The ramification pattern of villi, classified into hypo-, moderate-and hyper-ramifications, was shown to be mostly moderate in the non-diabetics whereas most of the diabetic placentae had either hypo-or hyper-ramifications. Mothers with a longer duration of diabetes and complicated with retinopathy tended to have hypo-ramification ; in these mothers, the weight of the neonates was significantly less than normal. Moreover, in the diabetic placentae, syncytial knots were found more frequently, the percentage of vasculo-syncytial membranes tended to be lower, and the trophoblastic basement membrane was significantly thicker than in the control. These abnormalities in the diabetic placentae were independent of the methods of delivery ; they seem to be related with fetal growth retardation and poor neonatal outcome, which are commonly seen in diabetic pregnancy. diabetic placenta ; electron microscopy ; quantitative investigation ; terminal villi

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“…Conversely, those placentae from patients with hypertension uncomplicated by preeclampsia have a similar or higher volume of parenchyma. Aherne and Dunnill (1966) 7 found that the volume proportion of chorionic tissue and of intervillous space in hypertensive pregnancies did not differ from the corresponding normal values, although there were differences in the absolute volume. They 2 did not find any significant difference in absolute volume, in the proportions of parenchymal and nonparenchymal tissues and in the distribution of the parenchymal tissue components between the placentae of the preeclamptic mothers and the control.…”

Section: Fig 3: Photograph Of the Cut Surface Of A Slice Of A Placenmentioning

confidence: 94%

“…The percentage of the total volume occupied by parenchyma and nonparenchyma was calculated by using the macroscopic point-counting techniques described by Aherne and Dunnill (1966) 6 . Parenchyma consists of villi, their fetal vessels and maternal intervillous space and nonparenchyma consists of chorionic and decidual plates, fetal vessels of diameter >0.1 cm and intercotyledonary septa along with the pathological components e.g.…”

Section: Methodsmentioning

confidence: 99%

Study of Proportional and Absolute Volume of Placental Parenchyma and Non-Parenchyma Between Normal Pregnant and Preeclamptic Women

et al. 1970

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The placenta is essential for the survival of the fetus. It undergoes different changes in weight, volume, structure, shape and function continuously throughout the gestation to support the prenatal life 1 . The architecture of the placenta is found to be changed in many maternal diseases like diabetes mellitus, hypertension, preeclampsia, eclampsia etc. Among those, gestational diabetes and preeclampsia are two pregnancy-induced metabolic diseases that may jeopardize the health of the mother and the fetus 2 . It is a remarkable matter that the placenta has got both anatomical and functional components

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Quantitative aspects of placental structure

Cited by 191 publications

References 18 publications

Morphological Changes of Placenta in Preeclampsia

Morphological Changes of Placenta in Preeclampsia

Quantitative Investigations of Placental Terminal Villi in Maternal Diabetes Mellitus by Scanning and Transmission Electron Microscopy.

Study of Proportional and Absolute Volume of Placental Parenchyma and Non-Parenchyma Between Normal Pregnant and Preeclamptic Women

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