Quantitative assessment of small bowel motility in patients with Crohn's disease using dynamic <scp>MRI</scp>

Hahnemann, Maria L.; Nensa, Felix; Kinner, Sonja; Köhler, Jens; Gerken, Guido; Umutlu, Lale; Lauenstein, Thomas C.

doi:10.1111/nmo.12558

Cited by 33 publications

(36 citation statements)

References 27 publications

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“…MRI is non‐invasive, safe and widely available and, coupled with advances in post‐processing technologies, enables rapid and repeatable quantification . Encouragingly, the first steps toward clinical implementation have been taken with dynamic motility imaging now being routine in various centers and with several prospective clinical studies being published …”

Section: Introductionmentioning

confidence: 99%

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Jonge

Menys

Rijn

et al. 2018

Neurogastroenterology Motil

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Objective MRI is increasingly used to evaluate small bowel contractility. The objective of this study was to validate a clinically practical stimulation test (300‐kcal meal) for small bowel motility. Methods Thirty‐one healthy subjects underwent dynamic MRI to capture global small bowel motility after ±10h fasting, of which 15 underwent bowel preparation consisting of 1 L 2.5% mannitol solution and 16 did not. Each subject underwent (1) a baseline motility scan (2) a food challenge (3) a post‐challenge scan, and (4) second post‐challenge scan (after ±20 minutes). This protocol was repeated within 2 weeks. Motility was quantified using a validated motility assessment technique. Key Results Motility in prepared subjects at baseline was significantly higher than motility in unprepared subjects (0.36 AU vs 0.18 AU, P < 0.001). In the prepared group, the food challenge produced an 8% increase in motility (P = 0.33) while in the unprepared subjects a significant increase of 30% was observed (P < 0.001). Responses to food remained insignificant (P = 0.21) and significant (P = 0.003), for the prepared and unprepared subjects, respectively, ±20 minutes post food challenge. These results were confirmed in the repeated scan session. Conclusion & Inferences A significant response to a 300‐kcal meal was measured within 10 minutes in unprepared bowel, supporting the clinical use of this challenge to provoke and assess motility changes. A caloric challenge did not produce an observable increase in motility in mannitol prepared subjects.

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Section: Introductionmentioning

confidence: 99%

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Jonge

Menys

Rijn

et al. 2018

Neurogastroenterology Motil

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“…motility using MRI is providing novel insights into CD pathophysiology. [9][10][11][12][13][14] Indeed, recent single-site data in 53 patients suggests that aberrant motility (notably a decreased variability) in apparently healthy bowel may be linked to patient symptom burden in CD. 15 If this observation could be prospectively validated, MRI quantified bowel motility could provide new insights into the aetiology of abdominal symptoms in CD, act as a target for therapeutic monitoring and possibly aid drug development.…”

Section: Introductionmentioning

confidence: 99%

Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study

Gollifer

Menys

Makanyanga

et al. 2018

BJR

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“…Several studies show that small bowel motility quantified with dynamic MRI can be used as a biomarker of inflammatory activity in Crohn's disease and to differentiate healthy from diseased bowel . The motility in the terminal ileum was lower in Crohn's patients in comparison to healthy subjects .…”

Section: Clinical Implementationmentioning

confidence: 99%

“…The short observation periods associated with breath-hold protocols may seem inadequate to measure GI motility, but have shown good initial results 4,10,16,[20][21][22][23][24][25][26] and are very practical for clinical use. Recent work showed that in breath-hold scanning, using a displacement mapping quantification technique (described below), a temporal resolution of at least 1 image per second and duration of 15 seconds is required for robust assessment of motility.…”

Section: Image Acquisitionmentioning

confidence: 99%

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

Jonge

Smout

Nederveen

et al. 2017

Neurogastroenterology Motil

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Dynamic magnetic resonance imaging (MRI) of gastrointestinal motility has developed rapidly over the past few years. The non-invasive and non-ionizing character of MRI is an important advantage together with the fact that it is fast and can visualize the entire gastrointestinal tract. Advances in imaging and quantification techniques have facilitated assessment of gastric, small intestinal, and colonic motility in a clinical setting. Dynamic MRI is used in the stomach to measure frequency and amplitude of antral contractions. [3][4][5] It is used for the small bowel to look at segmental and global motility using frequency measures and surrogate measures. [6][7][8][9][10][11][12] In the colon it has been applied to assess motion and velocity of contents, wall motion and to study motility using surrogate measures. 13-17 So far there has been a paucity of validation studies. To our knowledge there is only one study in which dynamic MRI findings were compared to manometry, demonstrating 100% correlation between visualized colonic movements and intraluminal pressure changes. 17 The clinical value of dynamic MRI is under evaluation for pathologies like inflammatory bowel disease (IBD), chronic intestinal pseudo-obstruction (CIPO) and constipation. they quantified small bowel motility using dynamic MRI. 18 In this review we discuss the challenges and opportunities in evaluating gastrointestinal motility with dynamic MRI. The first part of this review summarizes the technical aspects of the dynamic MRI technique; the second part discusses the observations made by applying the described

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Quantitative assessment of small bowel motility in patients with Crohn's disease using dynamic MRI

Abstract: Quantitative assessment of motility alterations by means of motility scoring in small bowel segments affected by CD provides additional information on inflammatory activity.

Cited by 33 publications

References 27 publications

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

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