Quantitative Bestimmung der Suppression antikörperbildenden Milzzellen durch passives Enhancement nach Nierentransplantation bei Ratten

Dostal, G.; Mohr, Raphael; Kinský, R; Hermann, G.

doi:10.1007/978-3-642-48834-4_30

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1982

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“…Allorosettes were found to appear after renal transplantation [8,[18][19][20], skin transplantation [16,[25][26][27], or immunization with spleen cells [22,34] and tumor cells [7] between isohistogenic strains of rats and mice. Unlike xenorosette formation, allorosettes cannot be produced by red blood cell immunization, and there are no spontaneous A R F C [18,19].…”

Section: Introductionmentioning

confidence: 99%

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The nature of allorosette-forming cells in rats

Lempfrid

Hermann

1982

Res. Exp. Med.

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ARFC appear in the spleen after transplantation of organs or tissues and immunization with nucleated cells between isohistogenic rat strains. The allorosette formation of rat spleen cells and T cells, isolated by an Ig-anti-Ig column, was examined. It has been demonstrated that 90% of ARFC are B cells and 10% are T cells. The allorosette phenomenon can therefore be considered an immune reaction concerning predominantly the B-cell system. Allorosette-forming T cells are discussed to be SD-antigen-recognizing cytotoxic T cells.

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Section: Introductionmentioning

confidence: 99%

“…In both cases allorosette formation can be suppressed by in vivo treatment with alloantisera directed against donor cells indicating the immunologic specificity of allorosette formation. The suppression of ARFC after renal transplantation is accompanied by a prolonged survival time of the kidney transplant [8,21].…”

Section: Introductionmentioning

confidence: 99%