Recently, commingling production has been widely used for the development of offshore heavy oil reservoirs with multilayers. However, the differences between layers in terms of reservoir physical properties, oil properties and pressure have always resulted in interlayer interference, which makes it more difficult to evaluate the producing degree of commingled production. Based on the Buckley–Leverett theory, this paper presents two theoretical models, a one-dimensional linear flow model and a planar radial flow model, for water-flooded multilayer reservoirs. Through the models, this paper establishes a dynamic method to evaluate seepage resistance, sweep efficiency and recovery percent and then conducts an analysis with field data. The result indicates the following: (1) the dynamic difference in seepage resistance is an important form of interlayer interference during the commingled production of an offshore multilayer reservoir; (2) the difference between commingled production and separated production is small within a certain range of permeability ratio or viscosity ratio, but separated production should be adopted when the ratio exceeds a certain value.