2011
DOI: 10.1111/j.1600-0560.2011.01763.x
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Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ

Abstract: These results show that Melan-A significantly overestimates the density of melanocytes within dermatoheliotic skin. Compared to other tested stains, nuclear staining MiTF allowed greater distinction of melanocytes from keratinocytes with melanized cytoplasm. These findings indicate that MiTF is a superior marker for quantification of melanocytes in the evaluation of subtle intraepidermal melanocytic proliferations and in the differential diagnosis of solar lentigo.

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Cited by 33 publications
(54 citation statements)
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“…9 As the diagnostic and treatment implications for these lesions are different, immunohistochemical markers are often employed to help assess the density of melanocytes and to differentiate melanoma from its mimics, which on small biopsies may be difficult to discern especially in cases exhibiting atypical melanocytic hyperplasia. 5,8,9 Several immunohistochemical studies, such as S100p, HMB-45, or MART-1, are routinely used to help differentiate melanocytes from adjacent keratinocytes. Nevertheless, the most commonly used adjunct immunohistochemical stain for the diagnosis of melanoma in situ probably is MART-1.…”
Section: Discussionmentioning
confidence: 99%
“…9 As the diagnostic and treatment implications for these lesions are different, immunohistochemical markers are often employed to help assess the density of melanocytes and to differentiate melanoma from its mimics, which on small biopsies may be difficult to discern especially in cases exhibiting atypical melanocytic hyperplasia. 5,8,9 Several immunohistochemical studies, such as S100p, HMB-45, or MART-1, are routinely used to help differentiate melanocytes from adjacent keratinocytes. Nevertheless, the most commonly used adjunct immunohistochemical stain for the diagnosis of melanoma in situ probably is MART-1.…”
Section: Discussionmentioning
confidence: 99%
“…For the assessment of intraepidermal melanocyte labeling of Sox10 compared with MITF, the mean number of melanocytes within a 1-mm length of epidermis was assessed as previously described. 15 Melanocyte density in normal skin (non-melanocytic excision specimens) (n = 10) was compared with skin with marked actinic damage (n = 8) and in the epidermis overlying dermal scars (n = 3).…”
Section: Immunohistochemistry For Sox10mentioning
confidence: 99%
“…At present, there are several biomarkers available for the identification of melanoma cells, such as microphthalmia transcription factor (MiTF), Melan-A, HMB-45 etc [5] . Among them, Melan-A is one of most important biomarkers and has been clinically used for the identification of melanoma cells.…”
Section: Discussionmentioning
confidence: 99%
“…Melanin is one of the characteristic components in melanocytes or melanoma cells. Melan A is one of most important biomarkers of melanoma [5] . If BMSCs transform toward melanoma, the aforementioned morphological features will be observed and Melan-A can be detected.…”
mentioning
confidence: 99%