Based on the principle of stereology to describe void fabric, the fabric tensor is redefined by the idea of normalization, and a novel quantitative description method for the orthotropic fabric of granular materials is presented. The scan line is described by two independent angles in the stereo space, and the projection of the scan line on three orthogonal planes is used to determine the plane tensor. The second-order plane tensor can be described equivalently by two invariants, which describe the degree and direction of anisotropy of the material, respectively. In the three-dimensional orthogonal space, there are three measurable amplitude parameters on the three orthogonal planes. Due to the normalized definition of tensor in this paper, there are only two independent variations of the three amplitude parameters, and any two amplitude parameters can be used to derive the three-dimensional orthotropic fabric tensor. Therefore, the same orthorhombic anisotropy structure can be described by three fabrics, which enriches the theoretical description of orthotropy greatly. As the geometric relationship of the stereoscopic space scan line changes, the three sets of orthotropic fabrics degenerate into different forms of transversely isotropic and isotropic fabrics naturally and have a clear physical meaning. The novel fabric tensor is quantitatively determined based on mathematical probability and statistics. The discrete distribution of voids in space is projected as a scalar measurable parameter on a plane. This parameter is related to the macroscopic constitutive relationship directly and can be used to describe the effect of microscopic voids on the macroscopic phenomenon of materials.