Quantitative Determination of 2-Methoxy-1, 4-Naphthoquinone in Plasma by High-Performance Liquid Chromatography

Thongnopnua, Phensri; Boonleang, Jutima; Chunejitbhong, Vilai; Vanichseni, Wallee

doi:10.2116/analsci.7.supple_1529

Anal. Sci.

1991

DOI: 10.2116/analsci.7.supple_1529

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Quantitative Determination of 2-Methoxy-1, 4-Naphthoquinone in Plasma by High-Performance Liquid Chromatography

Phensri Thongnopnua

Jutima Boonleang

Vilai Chunejitbhong

et al.

Abstract: A simple and sensitive high-performance~Uquid chromatographic method for the determination of spiked 2 methoxy-1,4~naphthoquinone in human plasma has been innovatively developed.A C18 reversed-phase column was used with a mobile phase consisting of methanol-acetate buffer p 4.0 (55 : 44 v/v) and UV detection at 275 rim. 2-Methyl-l,4-naphthoquinone was u ed as an internal standard.

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Quantitative determination of naphthoquinones of Impatiens species

Lobstein

Brenne²,

Feist³

et al. 2001

Phytochemical Analysis

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A convenient and reliable reversed phase-HPLC method has been developed and validated for the quantitative determination of naphthoquinones present in the aerial parts of Impatiens glandulifera (Balsaminaceae) during two growing seasons (May to August 1998 and June to October 1999). Maximal content (0.8-1.1%) of 2-hydroxy-1,4-naphthoquinone and its 2-methylated derivative was observed in flowers collected between July and August. The procedure was applied to compare the pigment content in three other species of Impatiens but showed 2.5-37 times lower levels than those found in I. glandulifera.

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Quantitative determination of naphthoquinones of Impatiens species

Lobstein

Brenne²,

Feist³

et al. 2001

Phytochemical Analysis

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show abstract

Chemical Composition and Biological Activity of Secondary Metabolites From Impatiens Balsamina

Zolotykh¹,

Pozdniakov²,

Glushko³

et al. 2022

JCPRM

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The review summarizes the literature data concerning the chemical composition of secondary metabolites and the types of biological activity of extracts and separate groups of secondary metabolites of Impatiens balsamina. First, data are given concerning the different types of biological activity of the extracts. Further, individual groups of secondary metabolites are considered, the corresponding structural formulas and types of biological activity established for this group of secondary metabolites are given. An attempt has been made to present the material about chemical composition and types of biological activity in chronological order. Extracts of I. balsamina have been shown to exhibit antiallergic, antihypotensive, antitumor, antinociceptive, antioxidant, antirheumatoid, antimicrobial, and antifungal activities. Among the secondary metabolites, peptides, naphthoquinones, polysaccharides, saponins, flavanoids, polyphenols, and tetrahydronaphthalene derivatives were identified. Research on peptides with a broad spectrum of antimicrobial activity is perspective. One of the most important groups of secondary metabolites are naphthoquinones, among which 2-methoxy-1,4-naphthoquinone is a significant metabolite, with which the antitumor effect of I. balsamina is associated. Also, this substance has shown in a number of tests an antifungal and antimicrobial activity exceeding the reference drug. Neuroprotective activity is simultaneously associated with a number of representatives of saponins, flavanoids, phenylpropanoids and tetrahydronaphthalene derivatives. This review shows that I. balsamina contains many groups of secondary metabolites, for which different types of biological activity have been identified. Due to the fact that the discussed plant is widely cultivated and is available, I. balsamina is a perspective object for the creation of new effective drugs.

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Quantitative Determination of 2-Methoxy-1, 4-Naphthoquinone in Plasma by High-Performance Liquid Chromatography

Cited by 2 publications

References 2 publications

Quantitative determination of naphthoquinones of Impatiens species

Quantitative determination of naphthoquinones of Impatiens species

Chemical Composition and Biological Activity of Secondary Metabolites From Impatiens Balsamina

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