Quantitative determination of benzoylecgonine and cocaine in human biofluids by gas-liquid chromatography

Kogan, Michael J.; Verebey, Karl; DePace, Ann; Resnick, Richard B.; Mulé, S. J.

doi:10.1021/ac50021a020

Cited by 84 publications

(18 citation statements)

References 27 publications

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“…To obtain an appreciation of the absolute bioavailability of cocaine by the intranasal and oral routes, we analyzed previously published plasma cocaine concentration-time data after intravenous (bolus) injection of cocaine described by Kogan et a1. 8 and Javaid et a1.,7 who injected cocaine HCl intravenously over 2 to 4 min in doses we estimated to be in the same range as those we used (i.e., 0.2 to 2.0 mg/kg). The AVCs were estimated by trapezoidal rule as in our studies.…”

Section: Discussionmentioning

confidence: 71%

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Intranasal and oral cocaine kinetics

Wilkinson

Dyke

Jatlow

et al. 1980

Clin Pharmacol Ther

221

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Plasma cocaine levels were determined in 7 subjects after intranasal and oral cocaine. Intranasal doses of 0.19, 0.38, 0.75, 1.5, and 2.0 mg/kg were given as a 10% aqueous solution; 0.38 mg/kg was given as crystalline cocaine HCl. Oral cocaine was administered in doses of 2.0 and 3.0 mg/kg. Intranasal cocaine kinetics were described by a 1-compartment open model with 2 consecutive first-order input steps and first-order elimination. Oral cocaine disposition was described by a 1-compartment open model with a lag time followed by a single first-order input phase and first-order elimination. The mean elimination half-life (t 1/2) for cocaine by the intranasal route to 7 subjects was 75 +/- 5 min (mean +/- SE). The mean t 1/2 after oral administration to 4 subjects was 48 +/- 3 min. The relative bioavailability [as determined by the area under the concentration-time curve (AUC)] for the 2.0-mg/kg dose by the intranasal and oral routes was not different. There was a linear increase in AUC with increasing intranasal dose.

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Section: Discussionmentioning

confidence: 71%

“…The AVCs after intranasal and oral doses were not significantly different, although both were smaller than that reported for similar intravenous doses of cocaine. 7,8 This difference in AVC may be due to saturation of first-pass plasma metabolism after an intravenous bolus.…”

Section: Discussionmentioning

confidence: 99%

Intranasal and oral cocaine kinetics

Wilkinson

Dyke

Jatlow

et al. 1980

Clin Pharmacol Ther

221

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show abstract

“…Several methods have been reported for the identification and quantification of COC and its metabolite in urine samples. These include immunoassay [1][2][3], gas chromatography [4][5][6][7], gas chromatography-mass spectrometry (GC-MS) [2,[8][9][10][11][12][13][14][15][16][17], and time-of-flight secondary ion mass spectrometry (TOF-SIMS) [18]. Currently, immunoassays are frequently employed for the identification of cocaine and its metabolites in biological fluids but it cannot be considered as a reliable quantitative assay because normally all positive results must be confirmed by other quantitative methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of cocaine and benzoylecgonine by direct injection of human urine into a column-switching liquid chromatography system with diode-array detection

Brunetto

Cayama

García

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…Since 1977, 11 studies have been conducted with a total of 76 subjects (Barnett et al 1981;Chow et al 1985;Cone 1995;Cone et al 1988;Cook et al 1985;Evans et al 1996;Isenschmid et al 1992;Javaid et al 1978Javaid et al , 1983Jeffcoat et al 1989;Kogan et al 1977). The most recent studies were conducted with six males (Cone 1995) and nine males (Evans et al 1996).…”

mentioning

confidence: 99%