Quantitative determination of famotidine polymorphs: X-ray powder diffractometric and Raman spectrometric study

Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis

“…Thus, DSC is routinely used to characterize amorphous systems, polymorphic changes studies, and in the quantification of the amorphous and crystalline contents in solid mixture [11][12][13]. The quantity of one polymorphic form can be estimated by either heat of crystallization or heat of fusion [14,15].…”

Determination and prediction of solubilities of active pharmaceutical ingredients in selected organic solvents

“…[7] and Bauer-Brandl [8]. Additionally, as described in our previous study [5], famotidine has two polymorphs, forms A and B [9][10][11][12][13]. The purification of each polymorph of cimetidine and famotidine was therefore performed.…”

“…5 mg, at a heating rate of 10 K min −1 . The experimental T fus,i and H fus,i values and the literature values [2,[8][9][10][11][12][22][23][24][25][26] are listed in Table 3. The purities of the organic solvents were checked using a gas chromatograph (GC-4000, GL Sciences Co., Ltd., Tokyo, Japan) with a thermal conductivity detector; the results are listed in Table 2.…”

“…The chemical structures and molecular weights of the four APIs investigated in this work are shown in Table 1. The solubilities of these APIs in different alcohols, namely methanol, ethanol, 2-propanol, 1-octanol, and poly(ethylene glycol) (PEG) 400, were determined in the M a n u s c r i p t 4 4 temperature range of 260-360 K. Several polymorphs of cimetidine and famotidine have been reported [7][8][9][10][11][12][13], therefore these compounds were characterized using powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) before the solubility measurements. The experimental solubility data were represented by two activity coefficient models, i.e., NRTL [14] and UNIQUAC [15].…”

Polymorphism and Solvatomorphism 2009

“…48 Results obtained using multivariate data processing and a univariate method were compared with their precision, accuracy, and robustness, and it was reported that both approaches provided similar results. During an attempted cocrystallization of racemic felodipine with isonicotinamide, the metastable Form-II polymorph of felodipine was obtained instead, and the structure of this polymorph was reported.…”