Quantitative Determination of Fluconazole in Syrups by First Order Derivative Spectrophotometry

Aboul‐Enein, Hassan Y.; Göǧer, Nilgün Günden; Türkalp, Alphun

doi:10.1081/al-120005972

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…However, the reproducibility of the proposed method was slight lower as compared with the spectrophotometric (RSD < 3%), [20][21][22] while the sensitivity was similar to those reported for chromatographic methods, 5,6,23 which is in the order of µg mL -1 . No more comparison of results is possible since that there is no electroanalytical method described for fluconazole determination and, therefore the simplicity, rapidity and low cost of the proposed method should be taking in account.…”

Section: Resultssupporting

confidence: 75%

Electrochemical Behavior and Determination of Fluconazole

Gil¹,

Cordeiro²,

Matias³

et al. 2011

J. Braz. Chem. Soc.

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O comportamento eletroquímico do fluconazol demonstrou oxidação irreversível com mecanismos eletroquímicos-químicos dependentes do material eletródico. Em eletrodos de Pt observou-se adsorção do reagente sob a aplicação de potenciais positivos, enquanto adsorção preferencial dos produtos foi observada em eletrodo de carbono vítreo. Em valores de pH inferiores a 7,0, a corrente do processo anódico é intensamente diminuída. Em eletrodo de pasta de carbono e tampão fosfato, pH 8,0, a corrente de oxidação variou linearmente com a concentração de fluconazol em solução, Ipa = 5,7×10 -5 (mA) × 0,052 [Fluconazol] (µg mL -1 ), no intervalo de 48,0 a 250,0 µg mL -1 . O limite de detecção obtido foi 6,3 µg mL -1 .The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical -chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10 -5 (mA) × 0.052 [Fluconazol] (µg mL -1 ), in the range of 48.0 to 250.0 µg mL -1. The detection limit obtained was 6.3 µg mL -1 .

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Section: Resultssupporting

confidence: 75%

Electrochemical Behavior and Determination of Fluconazole

Gil¹,

Cordeiro²,

Matias³

et al. 2011

J. Braz. Chem. Soc.

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“…In recent years, the literature has been showing an increase in the methods based on the derivative spectrophotometry. It allows enhancement of the resolution of overlapping spectra and selective discrimination of sharp bands over broad bands, thereby offering effective approaches to analysis of drug association and impurities (Erk and Gönüllü 2002;Malliou, Antoniou, and Koundourellis 2002;Erk 2002;Aboul-Eneim, Goger, and Turkalp 2002;Uslu and Ozkan 2002;Joseph-Charles et al 2003;Biryol and Erk 2003).…”

Section: Introductionmentioning

confidence: 98%

Furosemide Determination by First‐Derivative Spectrophotometric Method

2005

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Furosemide was analyzed in tablet and liquid pharmaceutical preparations entirely and after photolitic degradation, by direct ultraviolet first derivative spectrophotometry 1 D at 262 nm. At this wavelength, it was possible to eliminate the decomposition product interference. A linear response range between 1.0 and 10.0 mg mL 21 was obtained in optimized conditions. The estimation of relative standard deviation was within the range 0.37 -2.4% (n ¼ 10). The method was applied in pharmaceutical preparation samples, and the results were compared with those obtained with normal spectrophotometric method to determine furosemide with advantages as high selective, accuracy and precision

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“…Derivative spectrophotometry was already used in assays of fluconazole in other pharmaceutical preparations, from which the active principle was much easier to extract, such as capsules, injection solutions [13] and syrups [14]. First derivative of fluconazole spectrum showed maximum at 252.2 nm and minimum at 268.4 nm (Figure 2(a)).…”

Section: Specificitymentioning

confidence: 99%

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

Elezović¹,

Elezovic²,

Hadzović³

2011

AJAC

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Nail lacquers represent new drug form specifically designed to treat infected nail plate. They are complex organic solutions with specific assaying problems due to the high content of the polymer and plasticizer. Furthermore, there is a lack of assaying methods of active substances from this type of formulations in scientific literature. We developed derivative UV-spectrophotometric method for determination of fluconazole content in antifungal nail lacquer formulations. The method was validated for specificity, linearity, precision (repeatability), intermediate precision and accuracy (recovery). The method is specific, linear in the range of 99.53 -497.65 μg/ml, precise and showed good recovery (98.79% -101.77% from all six developed formulations). Besides, it is inexpensive, simple and nontoxic, i.e. ecologically acceptable. This method can be used for assaying fluconazole from this type of formulations.

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Quantitative Determination of Fluconazole in Syrups by First Order Derivative Spectrophotometry

Cited by 13 publications

References 19 publications

Electrochemical Behavior and Determination of Fluconazole

Electrochemical Behavior and Determination of Fluconazole

Furosemide Determination by First‐Derivative Spectrophotometric Method

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

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