Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection

Meijer, R.P.; Manen, Labrinus van; Hartgrink, Henk H.; Burggraaf, Jacobus; Gioux, Sylvain; Vahrmeijer, Alexander L.; Mieog, J. Sven D.

doi:10.1117/1.jbo.26.6.060501

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…The lack of a standard evaluation is the biggest issue. The conclusion of the research by Meijer [ 34 ] was that similar intraoperative fluorescence results might result in different surgical strategies, demonstrating the difficulty of interpreting uncorrected fluorescence signals. The quantification and standardisation of real-time NIR fluorescence perfusion imaging may aid surgeons.…”

Section: Resultsmentioning

confidence: 99%

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Simion,

Ionescu,

Chitoran

et al. 2023

Medicina

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Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent emphasis of a minute liver tumour, counting just 200 tumour cells; facilitation of fistula diagnosis; and tumour tattooing. This methodology can also be used with quantitative characteristics such as maximum intensity, relative maximum intensity, and in-flow parameters such as time-to-peak, slope, and t1/2max. This article concludes that fluorescence surgery with ICG and near-infrared (NIR) light is a relatively new technology that improves anatomical and functional information, allowing more comprehensive and safer tumour removal and the preservation of important structures.

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Section: Resultsmentioning

confidence: 99%

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Simion,

Ionescu,

Chitoran

et al. 2023

Medicina

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“…The most significant limitation is the lack of a universally replicable standard evaluation. The conclusion of the research by Meijer [34] was that similar intraoperative fluorescence results might result in different surgical strategies, demonstrating the difficulty of interpreting uncorrected fluorescence signals. Surgeons may soon benefit from the quantification and standardization of real-time NIR fluorescence perfusion imaging.…”

Section: Recto-colonic Perfusionmentioning

confidence: 99%

Indocyanine Green(Icg) And Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Simion¹,

Ionescu²,

Chitoran³

et al. 2023

Preprint

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Background: This literature review investigates qualitative and quantitative uses of indocyanine green (ICG) in surgical treatment, as this novel technique has become increasingly popular in ORs (operating rooms) worldwide due to its many advantages. Method: An extensive literature review was performed by searching for relevant terms in 5 international databases (www.pubmed.gov, www.sciencedirect.com, www.scopus.com, www.Oxfordjournals.com, www.reaxys.com). The results of this search were summarized into the main advantages of employing ICG in colorectal surgery as follows: a) intraoperative fluorescence angiography capability; b) fluorescence-guided identification of lymph node involvement in colorectal cancer and the sentinel lymph node method; c) positive fluorescence flagging of a liver tumour as small as "only" 200 tumour cells; d) facilitation of fistula diagnosis; and e) tumour tattooing. Moreover, in addition to qualitative intraoperative ICG use, this technique can be combined with quantitative methods and parameters, such as maximum intensity, relative maximum intensity, and different inflow parameters (time-to-peak, slope, and t1/2max). The conclusion of this article is that fluorescence surgery with ICG aided by near-infrared (NIR) light is a relatively recent technology, an advantage of which is improving the specific anatomic and functional information provided, thus allowing more comprehensive and safer tumour removal as well as preservation of important structures.

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“…Research prototypes have been designed to further correct not only distance and field homogeneity, but also optical properties, even in real-time. Finally, the temporal behavior of the fluorescence signal is being investigated as a source of contrast, notably for the imaging of blood perfusion (Matsui et al, 2009;Diana et al, 2015;Meijer et al, 2021). This method referred to as fluorescence dynamics is less dependent on several external and internal factors.…”

Section: Fluorescence Imagingmentioning

confidence: 99%

Trident: A dual oxygenation and fluorescence imaging platform for real-time and quantitative surgical guidance

Ségaud

Baratelli²,

Felli³

et al. 2022

Front. Photon.

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Despite recent technological progress in surgical guidance, current intraoperative assessment of tissue that should be removed (e.g., cancer) or avoided (e.g., nerves) is still performed subjectively. Optical imaging is a non-contact, non-invasive modality that has the potential to provide feedback regarding the condition of living tissues by imaging either an exogenously administered contrast agent or endogenous constituents such as hemoglobin, water, and lipids. As such, optical imaging is an attractive modality to provide physiologically and structurally relevant information for decision-making in real-time during surgery. The Trident imaging platform has been designed for real-time surgical guidance using state-of-the-art optical imaging. This platform is capable of dual exogenous and endogenous imaging owing to a unique filter and source combination, allowing to take advantage of both imaging modalities. This platform makes use of a real-time and quantitative imaging method working in the spatial frequency domain, called Single Snapshot imaging of Optical Properties (SSOP). The Trident imaging platform is designed to comply with all relevant standards for clinical use. In this manuscript, we first introduce the rationale for developing the Trident imaging platform. We then describe fluorescence and endogenous imaging modalities where we present the details of the design, assess the performance of the platform on the bench. Finally, we perform the validation of the platform during an in vivo preclinical experiment. Altogether, this work lays the foundation for translating state-of-the-art optical imaging technology to the clinic.

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Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection

Cited by 5 publications

References 21 publications

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Indocyanine Green(Icg) And Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage

Trident: A dual oxygenation and fluorescence imaging platform for real-time and quantitative surgical guidance

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