Quantitative Echocardiographic Analysis of Global and Regional Left Ventricular Function: A Problem Revisited

Assmann, Patricia E.; Slager, Cornelis J.; Borden, S. G. van der; Dreysse, Stephan; Tijssen, Jan G.P.; Sutherland, George R.; Roelandt, Jos R.T.C.

doi:10.1016/s0894-7317(14)80364-7

Cited by 37 publications

(12 citation statements)

References 23 publications

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“…Namely, although conventional ultrasound technique is widely used for the evaluation of regional LV function as it depicts in real time wall motion (endocardial excursion and myocardial thickening), it is only a qualitative method that is both subjective and observerdependent. 13 In contrast, TDI, which directly measures indexes of myocardial function within the myocardial wall, has been validated for the computerized quantification of transmural contractile function and has proven to be highly sensitive and specific for the detection of decreased myocardial function due to ischemic or cardiomyopathy processes. 14 -16 Thus, the results of our blinded analysis showing the absence of between-group difference in posttransplantation TDI data provide compelling evidence that BM cell injections failed to preserve postinfarction function.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Autologous Fresh Bone Marrow Into Infarcted Myocardium: A Word of Caution

et al. 2003

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Background-As the benefits of extemporaneous transplantation (Tx) of fresh (unfractionated) autologous bone marrow (BM) have been primarily studied in the setting of acute myocardial infarction, we assessed whether this approach could be effective for regenerating chronically infarcted myocardium. Methods and Results-Myocardial infarction was created in 18 sheep by ligation of circumflex arterial branches. Three weeks later, BM was aspirated from the iliac crest, washed, labeled with the fluorescent dye Dil and reinjected (mean: 422ϫ10 6 cells in 3 mL) in 10 sites across the infarcted area through the reopened thoracotomy (nϭ9). Nine controls received culture medium. Left ventricular (LV) function was assessed before and 2 months after Tx by two-dimensional echocardiography whereas transmural velocity gradients were measured using M-mode tissue Doppler imaging at the center of the infarcted/grafted area. Formalin-fixed hearts were processed for the detection of grafted cells and angiogenesis. LV ejection fraction deteriorated similarly in the Tx and control groups (from 42Ϯ5% to 30Ϯ4% and from 40Ϯ4% to 31Ϯ1%, respectively; Pϭ0.86). Likewise, BM Tx failed to prevent LV dilatation and impairment of the global wall motion score. The decrease in regional systolic velocity gradients (s

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Section: Discussionmentioning

confidence: 99%

Transplantation of Autologous Fresh Bone Marrow Into Infarcted Myocardium: A Word of Caution

et al. 2003

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“…17 Various quantitative techniques have been developed that use offline systems' manual tracing of endocardial borders, but they are usually tedious and impractical for routine clinical use. 18 Automatic edge-or border-detection techniques have, likewise, been shown to correlate with other available techniques, but they are complicated by endocardial dropouts and trabeculae, and by artefacts that impair the tracing of the endocardial border. 19 The determination of myocardial wall velocities has been suggested by many investigators as a more useful index of regional contractility than other estimates of LV function.…”

Section: Discussionmentioning

confidence: 99%

Apical tissue tracking echocardiography for characterization of regional left ventricular function: Comparison with magnetic resonance imaging in patients after myocardial infarction

Borges

Kivelitz

Walde

et al. 2003

Journal of the American Society of Echocardiography

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“…To minimise beat to beat variability, all recordings were made in gently held expiration. 21 Studies were recorded onto super VHS videotape for oV line analysis. Left ventricular contractile function was assessed in the apical two chamber (AP2CH) and apical four chamber (AP4CH) views, as described in the guidelines from the American Society of Echocardiography.…”

Section: Echocardiographymentioning

confidence: 99%

“…21 Three consecutive beats (excluding extrasystolic and postextrasystolic beats) were analysed for each time point in the AP2CH and AP4CH views. Endocardial borders (excluding papillary muscles) were traced at end diastole, timed as the closure of the mitral valve leaflets, and at end systole, defined as the point of maximum inward excursion of the endocardial contour.…”

Section: Echocardiographic Analysismentioning

confidence: 99%

Abnormal ventricular conduction following dothiepin overdose simulating acute myocardial infarction

Steeds¹

2000

Heart

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Objective-To determine whether pharmacological stress leads to prolonged but reversible left ventricular dysfunction in patients with coronary artery disease, similar to that seen after exercise. Design-A randomised crossover study of recovery time of systolic and diastolic left ventricular function after exercise and dobutamine induced ischaemia. Subjects-10 patients with stable angina, angiographically proven coronary artery disease, and normal left ventricular function. Interventions-Treadmill exercise and dobutamine stress were performed on diVerent days. Quantitative assessment of systolic and diastolic left ventricular function was performed using transthoracic echocardiography at baseline and at regular intervals after each test. Results-Both forms of stress led to prolonged but reversible systolic and diastolic dysfunction. There was no diVerence in the maximum double product (p = 0.53) or ST depression (p = 0.63) with either form of stress. After exercise, ejection fraction was reduced at 15 and 30 minutes compared with baseline (mean (SEM), −5.6 (1.5)%, p < 0.05; and −6.1 (2.2)%, p < 0.01), and at 30 and 45 minutes after dobutamine (−10.8 (1.8)% and −5.5 (1.8)%, both p < 0.01). Regional analysis showed a reduction in the worst aVected segment 15 and 30 minutes after exercise (−27.9 (7.2)% and −28.6 (5.7)%, both p < 0.01), and at 30 minutes after dobutamine (−32 (5.3)%, p < 0.01). The isovolumic relaxation period was prolonged 45 minutes after each form of stress (p < 0.05). Conclusions-In patients with coronary artery disease, dobutamine induced ischaemia results in prolonged reversible left ventricular dysfunction, presumed to be myocardial stunning, similar to that seen after exercise. Dobutamine induced ischaemia could therefore be used to study the pathophysiology of this phenomenon further in patients with coronary artery disease. (Heart 2000;83:283-289)

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Quantitative Echocardiographic Analysis of Global and Regional Left Ventricular Function: A Problem Revisited

Cited by 37 publications

References 23 publications

Transplantation of Autologous Fresh Bone Marrow Into Infarcted Myocardium: A Word of Caution

Transplantation of Autologous Fresh Bone Marrow Into Infarcted Myocardium: A Word of Caution

Apical tissue tracking echocardiography for characterization of regional left ventricular function: Comparison with magnetic resonance imaging in patients after myocardial infarction

Abnormal ventricular conduction following dothiepin overdose simulating acute myocardial infarction

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