Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients

Vázquez‐Marrufo, Manuel; González-Rosa, Javier J.; Vaquero, Encarna; Duque, Pablo; Borges, Marcos R. S.; Gómez, Carlos; Izquierdo, Guillermo

doi:10.1186/1471-2377-8-44

Cited by 20 publications

(28 citation statements)

References 48 publications

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“…Our finding of larger attention-cueing effects in individuals with MS is consistent with one interpretation of the seemingly paradoxical results of Gonzalez-Rosa et al (2006) and Vazquez-Marrufo et al (2008) that MS participants exhibited smaller cueing effects than did control participants. Both sets of results could be explained by intact attentional capture by salient peripheral cues but impairment in voluntary orienting of attention.…”

Section: Discussionsupporting

confidence: 88%

“…This would result in a relatively small RT difference between responses for validly and invalidly cued target locations. Furthermore, this pattern of results should be especially likely to occur when target detection or discrimination does not require highly focused attention, as was the case in previous studies (Gonzalez-Rosa, et al, 2006; Vazquez-Marrufo, et al, 2008; Vázquez-Marrufo, et al, 2009). By contrast, the current study presented a salient peripheral cue, and target stimuli that were difficult to discriminate without focused attention.…”

Section: Discussionsupporting

confidence: 57%

“…Interestingly, in the subset of those studies that reported reliable group differences in cueing effect magnitudes (Gonzalez-Rosa, et al, 2006; Vazquez-Marrufo, et al, 2008), smaller cueing effects were found for MS than for control participants. In those experiments, a central arrow cue indicated with 80% validity the location (left or right of fixation) in which a single stimulus would appear.…”

Section: Discussionmentioning

confidence: 95%

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Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Gmeindl¹,

Courtney²

2012

Neuropsychology

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Objective To investigate whether spatial working memory (WM) is impaired in multiple sclerosis (MS), and, if it is, to localize impairment to specific cognitive subprocess(es). Method In Experiment 1, MS and control participants performed computerized memory-span and visuomotor tasks. WM subprocesses were taxed by manipulating (1) the requirement to remember serial order, (2) delay duration, and (3) the presence of irrelevant stimuli during target presentation. In Experiment 2, recall and recognition tests varied the difficulty of WM retrieval. In Experiment 3, an attention-cueing task tested the ability to voluntarily and rapidly reorient attention. Results Performance was worse for MS than for control participants in both spatial recall (Exp. 1 span: 95% CIMS = [5.11, 5.57], 95% CIControls = [5.58, 6.03], p = 0.003, 1-tailed; Exp. 2 span: 95% CIMS = [4.44, 5.54], 95% CIControls = [5.47, 6.57], p = 0.006, 1-tailed) and recognition (accuracy: 95% CIMS = [0.71, 0.81], 95% CIControls = [0.79, 0.88], p = 0.01, 1-tailed) tests. However, there was no evidence for deficits in spatiotemporal binding, maintenance, retrieval, distractor suppression, or visuomotor processing. In contrast, MS participants were abnormally slow to reorient attention (cueing effect (ms): 95% CIMS: [90, 169], 95% CIControls: [29, 107], p = 0.015, 1-tailed). Conclusions Results suggest that, whereas spatial WM is impaired in MS, once spatial information has been adequately encoded into WM, individuals with MS are, on average, able to maintain and retrieve this information. Impoverished encoding of spatial information, however, may be due to inefficient voluntary orienting of attention.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 95%

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Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Gmeindl¹,

Courtney²

2012

Neuropsychology

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“…Yet, another group used computerized spectral analysis to demonstrate a positive relation between patients' disability and increased theta power over the temporal regions and increased beta power over the frontal regions, where visual interpretation of the EEG failed to demonstrate any correlations (Colon et al, 1981). Power spectral density analysis of EEG data, obtained during an auditory oddball task, revealed increased power in beta and gamma bands (especially over midfrontal areas) in MS patients compared to healthy controls (Vazquez-Marrufo et al, 2008). Similarly, for a visuo-spatial task, more beta and gamma power was found over occipital and right-frontal regions in relapsing remitting MS patients compared to a group of healthy controls, but no differences were found in the high frequency bands during resting-state, nor were there any significant correlations between quantitative EEG (QEEG) scores and Expanded Disability Status Scale (EDSS) (Vazquez-Marrufo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Cognition in MS correlates with resting-state oscillatory brain activity: An explorative MEG source-space study

Meer

Tewarie

Schoonheim

et al. 2013

NeuroImage: Clinical

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Clinical and cognitive dysfunction in Multiple Sclerosis (MS) is insufficiently explained by structural damage as identified by traditional magnetic resonance imaging (MRI) of the brain, indicating the need for reliable functional measures in MS. We investigated whether altered resting-state oscillatory power could be related to clinical and cognitive dysfunction in MS. MEG recordings were acquired using a 151-channel whole-head MEG system from 21 relapsing remitting MS patients and 17 healthy age-, gender-, and education-matched controls, using an eyes-closed no-task condition. Relative spectral power was estimated for 78 regions of interest, using an atlas-based beamforming approach, for classical frequency bands; delta, theta, alpha1, alpha2, beta and gamma. These cortical power estimates were compared between groups by means of permutation analysis and correlated with clinical disability (Expanded Disability Status Scale: EDSS), cognitive performance and MRI measures of atrophy and lesion load. Patients showed increased power in the alpha1 band and decreased power in the alpha2 band, compared to controls, mainly in occipital, parietal and temporal areas, confirmed by a lower alpha peak-frequency. Increased power in the alpha1 band was associated with worse overall cognition and especially with information processing speed. Our quantitative relative power analysis of MEG recordings showed abnormalities in oscillatory brain dynamics in MS patients in the alpha band. By applying source-space analyses, this study provides a detailed topographical view of abnormal brain activity in MS patients, especially localized to occipital areas. Interestingly, poor cognitive performance was related to high resting-state alpha1 power indicating that changes in oscillatory activity might be of value as an objective measure of disease burden in MS patients.

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“…Coherence analysis is a useful indicator of functional connections between different cortical areas [39], which are disrupted in multiple sclerosis. Cognitive impaired MS patients had a significant increase of theta power over the frontal regions [39] as well as an increase in beta and gamma bends [69] and a diffuse coherence decrease [19,39].…”

Section: Introductionmentioning

confidence: 98%

Stroop event-related potentials as a bioelectrical correlate of frontal lobe dysfunction in multiple sclerosis

Amato

Cursi

Rodegher

et al. 2016

Mult Scler Demyelinating Disord

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Background: Dysfunction of higher cognitive abilities occurs in 40-60 % of people with multiple sclerosis (MS), as detected with neuropsychological testing, with predominant involvement of executive functions and processing speed. Event-related potentials to the Stroop are a bioelectrical correlate of executive function. We tested whether event-related potentials to the executive Stroop test may reflect executive dysfunction in MS.

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Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients

Cited by 20 publications

References 48 publications

Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Cognition in MS correlates with resting-state oscillatory brain activity: An explorative MEG source-space study

Stroop event-related potentials as a bioelectrical correlate of frontal lobe dysfunction in multiple sclerosis

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