Quantitative Estimation of Lopinavir and Ritonavir in Tablets by RP-HPLC Method

Quality by design tool–evaluated stability‐indicating ultra‐performance liquid chromatography method for the determination of drugs (ritonavir and darunavir) used to treat the human immunodeficiency virus/acquired immunodeficiency syndrome

“…So far, only a few analytical techniques have been published for the chromatographic analysis of combination formulation, either separately or together. According to the literature review (Abduljalil & Badhan, 2016;Chiranjeevi & Channabasavaraj, 2011;Ettaboina et al, 2022;Grace & Parthiban, 2022;Jagadeeswaran et al, 2012;Kashish et al, 2020;Kavitha, 2020;Kumar et al, 2016;Lathouwers et al, 2011;Masaaki et al, 2021;Mishra & Shrivastav, 2014;Muchakayala et al, 2022;Pappula & Naresh, 2022;Patel et al, 2013;Paul et al, 2021;Raju et al, 2021;Rezk et al, 2009;Sabyasachi et al, 2021) none of these methods was found suitable for a stability-indicating analysis for quality control use.Thelonger run time used for quantification makes methods time consuming and cost-effective. In general, the technique should be enhanced or its robustness should be proven using the quality by design (QbD) approach, according to the present regulatory criteria, which are unambiguous.…”