“…167,172 Antipyrine derivatives are known to be biologically active as they exhibit antipyretic, analgesic and anti-inflammatory properties [167][168][169][170][171] and are used for medicinal screening processes as well. [173][174][175][176][177][178][179][180] Therefore, iodo-derivative 6 could be a useful building block for other biologically active antipyrine derivatives since iodination opens the door for further structural diversity. 167,180 Scheme 5 Investigated mechanochemical routes towards iodine(I) complex 4a.…”
Triturating N-iodosaccharin with electron-donating 4-substituted pyridines leads to either charge-neutral XB or cationic iodine(i) complexes, offering promising alternatives to the ubiquitous Barluenga's reagent as electrophilic iodination reagents.
“…167,172 Antipyrine derivatives are known to be biologically active as they exhibit antipyretic, analgesic and anti-inflammatory properties [167][168][169][170][171] and are used for medicinal screening processes as well. [173][174][175][176][177][178][179][180] Therefore, iodo-derivative 6 could be a useful building block for other biologically active antipyrine derivatives since iodination opens the door for further structural diversity. 167,180 Scheme 5 Investigated mechanochemical routes towards iodine(I) complex 4a.…”
Triturating N-iodosaccharin with electron-donating 4-substituted pyridines leads to either charge-neutral XB or cationic iodine(i) complexes, offering promising alternatives to the ubiquitous Barluenga's reagent as electrophilic iodination reagents.
“…This can be an important consideration with expensive reagents, for example, a microfluidic culture system at a flow rate of 1 µL min −1 would require only 10 mL of medium for an entire week. It is worth noting that the average flow of blood through tumour tissue is ∼0.8 mL g −1 min −1 6. Furthermore, recirculation of media can promote greater cell signalling as conditioning factors from the cells are secreted into the media; recirculation reduces media consumption too 7.…”
This review focuses on the development and use of microfluidic devices within a clinical setting. The underlying theoretical background of microfluidics is briefly elucidated. The materials and techniques used to fabricate the devices and their applicability to the clinical environment are described. The current research in this area is appraised and projections for future applications are discussed.
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