Quantitative Evaluation of Liver Function with Gd-EOB-DTPA-enhanced MR Imaging

哲, 山田

doi:10.2463/jjmrm.2019-1692

Cited by 2 publications

(7 citation statements)

References 27 publications

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“…Because the one-compartment model of Gd-EOB-DTPA in the ECF space of the liver (sinusoidal capillaries and Disse's space) is very similar to that of the spleen (splenic blood and EES) [16], the liver enhancement of the ECF approximates the spleen enhancement [22]. The peak enhancement of the spleen occurs approximately 1 min after intravenous injection [8,16,22]. After this peak, the SI S decreases over 40 min, with washout of the contrast agent [8,16].…”

Section: Discussionmentioning

confidence: 99%

“…Gd-EOB-DTPA distributes non-speci cally to the extracellular uid (ECF), which is present in the intravascular space (blood plasma) and extracellular extravascular space (EES) [8,16,22]. Because the one-compartment model of Gd-EOB-DTPA in the ECF space of the liver (sinusoidal capillaries and Disse's space) is very similar to that of the spleen (splenic blood and EES) [16], the liver enhancement of the ECF approximates the spleen enhancement [22]. The peak enhancement of the spleen occurs approximately 1 min after intravenous injection [8,16,22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the 40% of the Gd-EOB-DTPA in the ECF is speci cally taken up into the normal hepatocytes for biligenesis through the transporters on hepatocyte membranes: a Na + -taurocholate co-transporting polypeptide and the subfamilies of organic anion-transporting polypeptides. After uptake, Gd-EOB-DTPA actively excretes to biliary canaliculus by a multidrug resistance-associated protein (MRP) 2 that is used for bilirubin [22]. Through a decrease in the appearance of these transporters, non-conjugated bilirubin remains in the blood, and the uptake of Gd-EOB-DTPA is also suffocated.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Mori

Machimura

Iwaya

et al. 2021

Preprint

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The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin–bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, − 0.624, − 0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were − 0.647, − 0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 • LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4 %, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Mori

Machimura

Iwaya

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Gd-EOB-DTPA distributes non-specifically to the extracellular fluid (ECF), which is present in the intravascular space (blood plasma) and extracellular extravascular space (EES) 8 , 16 , 22 . Because the one-compartment model of Gd-EOB-DTPA in the ECF space of the liver (sinusoidal capillaries and Disse’s space) is very similar to that of the spleen (splenic blood and EES) 16 , the liver enhancement of the ECF approximates the spleen enhancement 22 . The peak enhancement of the spleen occurs approximately 1 min after intravenous injection 8 , 16 , 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Because the one-compartment model of Gd-EOB-DTPA in the ECF space of the liver (sinusoidal capillaries and Disse’s space) is very similar to that of the spleen (splenic blood and EES) 16 , the liver enhancement of the ECF approximates the spleen enhancement 22 . The peak enhancement of the spleen occurs approximately 1 min after intravenous injection 8 , 16 , 22 . After this peak, the SI S decreases over 40 min, with washout of the contrast agent 8 , 16 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests

Mori

Machimura

Iwaya

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin–bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, –0.624, –0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were –0.647, –0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 · LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4%, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.

show abstract

Quantitative Evaluation of Liver Function with Gd-EOB-DTPA-enhanced MR Imaging

Cited by 2 publications

References 27 publications

Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests

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