Quantitative evaluation of MPTP-treated nonhuman parkinsonian primates in the HALLWAY task

Campos‐Romo, Aurelio; Ojeda-Flores, Rafael; Moreno-Briseño, Pablo; Fernández-Ruíz, Juan

doi:10.1016/j.jneumeth.2008.10.026

Cited by 24 publications

(23 citation statements)

References 31 publications

(28 reference statements)

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“…The assessment methods were based on previously described procedures (Bankiewicz et al, 2001; Campos-Romo et al, 2009; Fahn and Elton, 1987; Verhave et al, 2009) and are thoroughly described in the Supplemental Information. Automatic motion tracking was performed using custom developed software in MATLAB.…”

Section: Methodsmentioning

confidence: 99%

Spinal Cord Stimulation Alleviates Motor Deficits in a Primate Model of Parkinson Disease

Santana

Halje

Simplício

et al. 2014

Neuron

104

119

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Summary Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson's disease (PD), just a small fraction of PD patients can take advantage of this procedure due to its invasive nature. A significantly less invasive method - epidural spinal cord stimulation (SCS) – has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in PD monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and excessive functional coupling among them. SCS disrupted this pathological circuit behavior in a manner that mimics the effects caused by pharmacological dopamine replacement therapy or deep brain stimulation. These results suggest that SCS should be considered as an additional treatment option for PD-patients.

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Section: Methodsmentioning

confidence: 99%

Spinal Cord Stimulation Alleviates Motor Deficits in a Primate Model of Parkinson Disease

Santana

Halje

Simplício

et al. 2014

Neuron

104

119

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“…Similar to our method, previous reports of computer-based video analysis of monkey movements use frame-by-frame analyses to quantify displacement of the animal, based on the number of pixels that change from one frame to the next (Campos-Romo et al, 2009;Chassain et al, 2001;Hashimoto et al, 1999;Togasaki et al, 2005). Some of these methods require specialized cameras and proprietary software.…”

Section: Discussionmentioning

confidence: 99%

“…Activity levels have also been assessed using computer-based analyses of video recordings of NHPs (Brouillet et al, 1995;Campos-Romo et al, 2009;Chassain et al, 2001;Hashimoto et al, 1999;Togasaki et al, 2005). However, in many cases the software is based on outdated computer systems or is proprietary, and the video analysis requires specialized equipment.…”

Section: Introductionmentioning

confidence: 99%

Quantification of movement in normal and parkinsonian macaques using video analysis

Caiola

Pittard

Wichmann³

et al. 2019

Journal of Neuroscience Methods

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Background: Quantification of spontaneous animal movement can be achieved using analysis of video recordings of the animals. Previous reports of video-based methods are based on outdated computer platforms or require the use of specialized equipment. New method: We developed a video analysis algorithm to quantify movement based on the commonly used MATLAB programming language. The algorithm is based on pixel differences between frames of video footage acquired with a standard video camera. Results: The new algorithm was validated, analyzing the amount of movements made by monkeys undergoing treatment with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP) to induce parkinsonism. We compared the movement quantification generated by the new system of analysis with results obtained with a conventional infrared beam break counting system, a parkinsonism rating scale, and accelerometry-based motion quantification in three rhesus macaques. The information provided by our video analysis method was consistent with that obtained with the first two methods, and more detailed than the third. Comparison with existing methods: The new method can replace other methods to quantify movement. Although other video analysis methods have been described, some have since been deprecated, or involve the use of specialized hardware. The new method provides a straightforward and fast approach of analyzing the amount of movement in caged experimental animals, using conventional off-the-shelf equipment and moderate computing resources. Conclusions: This video analysis method provides an affordable, open access platform to quantify animal movement.

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“…Also known as the vervet monkey, this primate is widely used in biomedical research, mainly due to low susceptibility and resistance to disease . This species has been used as a model for studies of human immunodeficiency virus (HIV) , Parkinson's disease , cardiovascular diseases , and pharmacology research related to immunology and cell biology .…”

Section: Introductionmentioning

confidence: 99%

Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

Imbeloni

Rahal

Filho

et al. 2015

J of Medical Primatology

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Quantitative evaluation of MPTP-treated nonhuman parkinsonian primates in the HALLWAY task

Cited by 24 publications

References 31 publications

Spinal Cord Stimulation Alleviates Motor Deficits in a Primate Model of Parkinson Disease

Spinal Cord Stimulation Alleviates Motor Deficits in a Primate Model of Parkinson Disease

Quantification of movement in normal and parkinsonian macaques using video analysis

Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

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