Quantitative Evaluation of the Maternal-Fetal Transfer of Free Fatty Acids in the Rat

L, Hummel; Schirrmeister, W; Wagner, H

doi:10.1159/000240737

Cited by 27 publications

(19 citation statements)

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“…The program was essentially the same as the program described by Berman et al [2], Details of the methods used have already been described [7]. Data of the specific activity of the maternal plasma and placental FFA, which have already been submitted for publication [8], were also used for the analysis of data.…”

Section: Methodsmentioning

confidence: 99%

Studies on the Lipid Metabolism Using <sup>14</sup>C-1-PaImitate in Fetal Rats

Hummel¹,

Schirrmeister²,

Zimmermann³

et al. 1974

Neonatology

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The following conclusions can be drawn from our experiments with regard to the fetal lipid metabolism, using the tracer technique and a mathematical model. (1) The fetal plasma free fatty acids (FFA) exchange so rapidly with another FFA compartment (probably the interstitially located FFA) that the FFA of both compartments can be considered as one homogeneous FFA compartment. The turnover time of this compartment was calculated to be 0.78 min. (2) 1.25 μmoles FFA/ min pass through this FFA compartment. This indicates that the rat fetus must dispose of a lipolytic activity comparable to that of the adult animal. (3) The amount of FFA esterified to fetal triglycerides is relatively greater than the amount of FFA esterified to fetal phospholipids. This finding reflects a certain accumulation of fat during the last days of pregnancy.

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Section: Methodsmentioning

confidence: 99%

Studies on the Lipid Metabolism Using <sup>14</sup>C-1-PaImitate in Fetal Rats

Hummel¹,

Schirrmeister²,

Zimmermann³

et al. 1974

Neonatology

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“…In species with a more permeable placenta like the rabbit [81][82][83][84], guinea-pig [85,86], rat [87][88][89], rhesus monkey [90] and humans [91][92][93], FFA and ketoacids are readily transferred from the mother to its foetuses. Fatty acids can cross the rabbit placenta in either direction [82].…”

Section: Fatty Acids Ketone Bodies and Glycerolmentioning

confidence: 99%

Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species

Père

2003

Reprod. Nutr. Dev.

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-Several general features of nutrient uptake and utilisation by foetuses are similar among mammalian species. Nevertheless, there are also differences linked mainly to differences in placental permeability. Glucose and lactate are the main energetic substrates of the foetus. In normal conditions, the oxidation of carbohydrates accounts for about 75, 60 and 50% of oxygen uptake in the foetal pig, foal and lamb, respectively, and acetate accounts for about 10% in ruminants. Acidic amino acids are synthesised by the foetus, whereas neutral and basic amino acids are transported from the placenta. As shown by the high urea level in foetal blood, amino acids are partly involved in the oxidative metabolism of foetuses; their contribution is higher in ruminants than in humans, horses and pigs. Fatty acids cross the haemochorial placenta of rodents, rabbits and primates, and are incorporated into the foetal lipids, whereas their uptake by ruminant, pig and horse foetuses is very low.materno-foetal exchange / mammal / carbohydrate / fatty acid / amino acid

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“…The extent of transport appears to be spe cies-dependent, ranging from rapid passage in guinea pigs and rabbits [9,15,16,25,30, 32] to minimal transport in ruminants [13,18,31], with intermediate rates of placental crossing in rats [10,11,17,24], primates [21], and women [3,8,28].…”

Section: Introductionmentioning

confidence: 99%

Increased Maternal-Fetal Transport of Fat in Diabetes Assessed by Polyunsaturated Fatty Acid Content in Fetal Lipids

Goldstein¹,

Lévy²,

Shafrir³

1985

Neonatology

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The distribution of fatty acids was determined by gas-liquid chromatography in total lipid and triglyceride fraction of extracts of several tissues of streptozotocin-diabetic rats and their fetuses on day 20 of pregnancy. In maternal rats, diabetes did not significantly affect fatty acid distribution apart from small changes in the relative content of linoleate in adipose tissue and liver. In the placenta, the fetal carcass and the fetal liver the triglyceride content increased approximately 2-fold as a result of maternal diabetes, in association with the elevation in triglycerides and free fatty acids in the maternal circulation. A pronounced increase in the relative content of linoleate was recorded in the total lipid and triglyceride extracts of placenta (35 and 59%), fetal carcass (56 and 66%) and fetal liver (100 and 205%). Small increases in arachidonate proportion were also seen in some fetal tissues. The large increase in fetal hepatic linoleate indicates that this tissue is an important uptake target of maternal lipids transported in excess into the fetus. The results confirm the previous observations on increased transplacental fat passage in diabetes by demonstrating that the increment in the essential fatty acid, linoleate, parallels the diabetes-induced triglyceride accumulation in the fetoplacental unit.

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Quantitative Evaluation of the Maternal-Fetal Transfer of Free Fatty Acids in the Rat

Cited by 27 publications

References 1 publication

Studies on the Lipid Metabolism Using <sup>14</sup>C-1-PaImitate in Fetal Rats

Studies on the Lipid Metabolism Using <sup>14</sup>C-1-PaImitate in Fetal Rats

Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species

Increased Maternal-Fetal Transport of Fat in Diabetes Assessed by Polyunsaturated Fatty Acid Content in Fetal Lipids

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