Quantitative FT-Raman analysis of two crystal forms of a pharmaceutical compound

Langkild̄e, Frans W.; Sjöblom, Jonas; Tekenbergs-Hjelte, Lija; Mrak, Jonni

doi:10.1016/s0731-7085(96)01906-1

Cited by 87 publications

(44 citation statements)

References 12 publications

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“…Spectroscopic techniques have demonstrated a high potential in polymorph identification and quantification, and also in process monitoring and control [30][31][32][33][34][35][36][37][38][39]. Traditional microscopy provides direct and fast identification of morphology, and when combined with Raman spectroscopy the physical information in terms of the internal structure of crystals can be obtained at the same time.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Tian

Louhi-Kultanen

et al. 2009

Journal of Crystal Growth

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Section: Introductionmentioning

confidence: 99%

Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Tian

Louhi-Kultanen

et al. 2009

Journal of Crystal Growth

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“…It has been used for the identification of active substances in pharmaceuticals, 12 their qualitative 13 and quantitative analysis, 14 the characterization of different crystalline forms 15,16 and even for online monitoring of the pharmaceutical blending process. 17 Raman spectroscopy has offered several advantages over other analytical technologies.…”

Section: Introductionmentioning

confidence: 99%

Detecting and Identifying the Complexation of Nimodipine with Hydroxypropyl-β-Cyclodextrin Present in Tablets by Raman Spectroscopy

Yang

et al. 2008

Journal of Pharmaceutical Sciences

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“…Raman spectroscopy has been used for the identification of active substances in pharmaceuticals, 14,15 their qualitative 16 and quantitative analysis, 17 the characterization of different crystalline forms 18,19 and even for on-line monitoring of the pharmaceutical blending process. 20 Moreover, the identification of illicit drugs (cocaine, heroin and MDMA) that are contaminated with one or more cutting agents 21,22 has been presented.…”

Section: Introductionmentioning

confidence: 99%

Fast detection and identification of counterfeit antimalarial tablets by Raman spectroscopy

Veij

Vandenabeele

Hall

et al. 2006

J Raman Spectroscopy

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During the last decade there has been an apparent increase in the prevalence of counterfeit medicines in developing as well as developed countries. The pivotal antimalarial artesunate has been counterfeited on a large scale in SE Asia. In this work, the possibilities of Raman spectroscopy are explored as a fast and reliable screening method for the detection of counterfeit artesunate tablets. In this study, 50 'artesunate tablets', purchased in SE Asia, were examined. This spectroscopic method was able to distinguish between genuine and counterfeit artesunate and to identify the composition of the counterfeit tablets. These contained no detectable levels of artesunate, but consisted mostly of starch, calcite (CaCO 3 ), and paracetamol (4-acetamidophenol). In one particular case an admixture of rutile (TiO 2 ) and artesunate was detected. The results of the investigation by Raman spectroscopy were in agreement with those of colorimetric tests and of liquid chromatography-mass spectrometry on the artesunate. Moreover, principal components analysis (PCA) was combined with hierarchical cluster analysis to establish an automated approach for the discrimination between different groups of counterfeits and genuine artesunate tablets. These results demonstrate that Raman spectroscopy combined with multivariate analysis is a promising and reliable methodology for the fast characterization of genuine and counterfeit artesunate antimalarial tablets.

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Quantitative FT-Raman analysis of two crystal forms of a pharmaceutical compound

Cited by 87 publications

References 12 publications

Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Detecting and Identifying the Complexation of Nimodipine with Hydroxypropyl-β-Cyclodextrin Present in Tablets by Raman Spectroscopy

Fast detection and identification of counterfeit antimalarial tablets by Raman spectroscopy

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