Quantitative genetic analysis of blood pressure reactivity to orthostatic tilt using principal components analysis

Choh, Audrey C.; Czerwinski, Stefan A.; Lee, M.; Demerath, Ellen W.; Cole, Shelley A.; Wilson, Alexander F.; Towne, Bradford

doi:10.1038/sj.jhh.1001975

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…Another study guaranteed that 30 minutes of tilt and an angle of 60 degrees represent the best available resource to investigate the blood pressure fall [21,23]. Our study also evidenced that BP pressure drop occurred during the first 20 minute period.…”

Section: Discussionsupporting

confidence: 66%

A Five-day Orthostatic Training Program Improves Cardiovascular Response in Intensive Care Patients

Tavares¹,

Vega²,

Guimarães³

et al. 2017

Int J Phys Med Rehabil

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Objective: To evaluate the cardiovascular response to passive orthostatic training. Method:Intensive care patients were recruited. Patients in Control group underwent conventional physical therapy. Patients in the Training group additionally underwent daily assistive standing training with the use of an orthostatic bed for five days. All patients in the Training group were evaluated while on the orthostatic table (at rest for 10 minutes, at 75 degrees of inclination for 40 minutes and after returning to the supine position). Heart rate and mean arterial pressure were assessed at each stage. Both groups were assessed at baseline and after seven days. Results:After the 5-day intervention patients from Control group had their mean arterial pressure decreased significantly (19 mmHg in average) when compared to baseline mean arterial pressure at the moment they had their body position elevated, with the worsening of postural hypotension in the following minutes, pattern which not found in the Training group patients. Conclusion:A five-day orthostatic training in intensive care patients can be safely performed and improves cardiovascular response.

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Section: Discussionsupporting

confidence: 66%

A Five-day Orthostatic Training Program Improves Cardiovascular Response in Intensive Care Patients

Tavares¹,

Vega²,

Guimarães³

et al. 2017

Int J Phys Med Rehabil

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“…Family studies have shown that the genetic contribution to the variation of individual blood pressure (BP) reached 23%, 1 and up to 60% shown in research on twins. 2 Epidemiological studies and clinical trials found that high BP is an independent risk factor for cardiovascular and cerebrovascular diseases, and also demonstrated the benefits of prevention and treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population

Yang

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Introduction:The prolylcarboxypeptidase (PRCP) gene encodes a membrane protein that acts on angiotensin II (Ang II) and kallikrein to release vasoactive peptides. The chymase (CMA1) gene is important for Ang II generation. Therefore, the two genes might be involved in the pathogenesis of essential hypertension (EH). Materials and Methods: Eleven tag single nucleotide polymorphisms (SNPs) in the PRCP gene and four tag SNPs and G-1903A (rs1800875) polymorphism in the CMA1 gene were genotyped in the Chinese Han population (n=1020) using a polymerase chain reaction-restriction fragment length polymorphism method. Results: In the PRCP gene, single site analyses indicated that the rs7104980 G allele was a susceptible factor for EH (adjusted odds ratio (OR)=1.98, 95% confidence interval (CI) 1.62-2.43, p=0.3×10 -10 ). The protective effect of Hap3 GAGCACTAACA was observed without carrying the susceptible rs7104908 G allele (OR=0.67, 95% CI 0.56-0.81, p=0.3×10 -4 ) by haplotype analyses. In the case of the CMA1 gene, no associations with EH were found through single site analyses. However, haplotype analyses showed that Hap16 TTTA significantly increased the risk of EH with OR=3.15 (p=0.0002) which may be driven by interaction with a nearby SNP combination. Conclusions:The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with EH in Chinese Han population.

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“…As clinical data of the participants were not available for this study, the issue of a possible relationship between the substantial initial BP spikes and 'white coat' responses, had to be left to future investigations. Our study adds to other research studies examining blood pressure variability combining genetics, neurobiological factors, and exaggerated stressor-evoked BP reactivity to the prediction of future cerebrovascular and cardiovascular events, placing emphasis on the development of future interventions, both pharmaceutical and nonpharmaceutical [38][39][40][41][42].…”

Section: Discussionmentioning

confidence: 81%

A psychophysiologic reaction to application of ambulatory blood pressure monitor

Yanovski¹,

Townsend²,

Ford³

et al. 2011

Blood Pressure Monitoring

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Results support the interpretation that the initial BP spikes with a substantial M-W difference represent psychophysiologic reactions triggered by the perceived stresses of the application of the ABPM. Substantial calibration spikes that connect to substantial 'first hour elevations' may be the start of a white coat response. The inclusion of valid calibration data in the analysis of the ABPM result is recommended.

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Quantitative genetic analysis of blood pressure reactivity to orthostatic tilt using principal components analysis

Cited by 7 publications

References 37 publications

A Five-day Orthostatic Training Program Improves Cardiovascular Response in Intensive Care Patients

A Five-day Orthostatic Training Program Improves Cardiovascular Response in Intensive Care Patients

Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population

A psychophysiologic reaction to application of ambulatory blood pressure monitor

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